Transducin Beta like Protein 2 (TbL2)

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WS-betaTRP; WBSCR13; Williams-Beuren Syndrome Chromosome Region 13; WS beta-transducin repeats protein

Transducin Beta like Protein 2 (TbL2)
TBL2 encodes a member of the beta-transducin protein family. Most proteins of the beta-transducin family are involved in regulatory functions. This protein is possibly involved in some intracellular signaling pathway. This gene is deleted in Williams-Beuren syndrome, a developmental disorder caused by deletion of multiple genes at 7q11.23.
TBL2 shares approximately 40% homology with a hypothetical C. elegans protein, suggesting that the gene has been conserved throughout evolution. Northern blot analysis detected a 2.4-kb transcript in all tissues examined, with high expression in heart, brain, placenta, skeletal muscle, and pancreas.Northern blot analysis of human tissues detected not only the 2.4-kb transcript, but an approximately 5-kb transcript which was ubiquitously expressed at lower levels.

Organism species: Homo sapiens (Human)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins n/a Recombinant Transducin Beta like Protein 2 (TbL2) Recombinant Protein Customized Service Offer
Antibodies n/a Monoclonal Antibody to Transducin Beta like Protein 2 (TbL2) Monoclonal Antibody Customized Service Offer
n/a Polyclonal Antibody to Transducin Beta like Protein 2 (TbL2) Polyclonal Antibody Customized Service Offer
Assay Kits n/a CLIA Kit for Transducin Beta like Protein 2 (TbL2) CLIA Kit Customized Service Offer
n/a ELISA Kit for Transducin Beta like Protein 2 (TbL2) ELISA Kit Customized Service Offer
  1. "TBL2, a novel transducin family member in the WBS deletion: characterization of the complete sequence, genomic structure, transcriptional variants and the mouse ortholog."Cytogenet. Cell Genet. 86:277-284(1999) [PubMed] [Europe PMC] [Abstract]
  2. "Towards a catalog of human genes and proteins: sequencing and analysis of 500 novel complete protein coding human cDNAs." Genome Res. 11:422-435(2001) [PubMed] [Europe PMC] [Abstract]
  3. "The secreted protein discovery initiative (SPDI), a large-scale effort to identify novel human secreted and transmembrane proteins: a bioinformatics assessment." Genome Res. 13:2265-2270(2003) [PubMed] [Europe PMC] [Abstract]
  4. "Complete physical map of the common deletion region in Williams syndrome and identification and characterization of three novel genes."Hum. Genet. 103:590-599(1998) [PubMed] [Europe PMC] [Abstract]
  5. "ATM and ATR substrate analysis reveals extensive protein networks responsive to DNA damage."Science 316:1160-1166(2007) [PubMed] [Europe PMC] [Abstract]
  6. "Initial characterization of the human central proteome."BMC Syst. Biol. 5:17-17(2011) [PubMed] [Europe PMC] [Abstract]
  7. "An enzyme assisted RP-RPLC approach for in-depth analysis of human liver phosphoproteome."J. Proteomics 96:253-262(2014) [PubMed] [Europe PMC] [Abstract]