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Thousand And One Amino Acid Protein Kinase 1 (TAOK1)

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MAP3K16; MARKK; PSK2; TAO1; hKFC-B; Kinase from chicken homolog B; Prostate-derived sterile 20-like kinase 2; Serine/threonine-protein kinase TAO1

Thousand And One Amino Acid Protein Kinase 1 (TAOK1)
CCC H063
HGNC 29259
MGI 1914490
PubMed 23472202
RGD 708455
UniProt Q7L7X3
Wiki TAOK1
Markk phosphorylated Mark on a threonine within its activation loop. In brain, Markk also phosphorylated a fraction of Mark on a nearby serine, and this phosphorylation inhibited Mark activity. In cells, Markk activity enhanced microtubule dynamics through activation of Mark and led to phosphorylation and detachment of microtubule-associated proteins from microtubules. The cDNA contains repetitive elements in its 5-prime and 3-prime regions, and the deduced 1,005-amino acid protein shares 99% identity with rat Tao1. Intermediate expression was detected in all other brain regions and adult and fetal tissues examined, with slightly higher levels in caudate nucleus, substantia nigra, whole adult brain, adult liver, and fetal liver.

Organism species: Homo sapiens (Human)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins n/a Recombinant Thousand And One Amino Acid Protein Kinase 1 (TAOK1) Recombinant Protein Customized Service Offer
Antibodies n/a Monoclonal Antibody to Thousand And One Amino Acid Protein Kinase 1 (TAOK1) Monoclonal Antibody Customized Service Offer
n/a Polyclonal Antibody to Thousand And One Amino Acid Protein Kinase 1 (TAOK1) Polyclonal Antibody Customized Service Offer
Assay Kits n/a CLIA Kit for Thousand And One Amino Acid Protein Kinase 1 (TAOK1) CLIA Kit Customized Service Offer
n/a ELISA Kit for Thousand And One Amino Acid Protein Kinase 1 (TAOK1) ELISA Kit Customized Service Offer

Organism species: Mus musculus (Mouse)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins n/a Recombinant Thousand And One Amino Acid Protein Kinase 1 (TAOK1) Recombinant Protein Customized Service Offer
Antibodies n/a Monoclonal Antibody to Thousand And One Amino Acid Protein Kinase 1 (TAOK1) Monoclonal Antibody Customized Service Offer
n/a Polyclonal Antibody to Thousand And One Amino Acid Protein Kinase 1 (TAOK1) Polyclonal Antibody Customized Service Offer
Assay Kits n/a CLIA Kit for Thousand And One Amino Acid Protein Kinase 1 (TAOK1) CLIA Kit Customized Service Offer
n/a ELISA Kit for Thousand And One Amino Acid Protein Kinase 1 (TAOK1) ELISA Kit Customized Service Offer

Organism species: Rattus norvegicus (Rat)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins n/a Recombinant Thousand And One Amino Acid Protein Kinase 1 (TAOK1) Recombinant Protein Customized Service Offer
Antibodies n/a Monoclonal Antibody to Thousand And One Amino Acid Protein Kinase 1 (TAOK1) Monoclonal Antibody Customized Service Offer
n/a Polyclonal Antibody to Thousand And One Amino Acid Protein Kinase 1 (TAOK1) Polyclonal Antibody Customized Service Offer
Assay Kits n/a CLIA Kit for Thousand And One Amino Acid Protein Kinase 1 (TAOK1) CLIA Kit Customized Service Offer
n/a ELISA Kit for Thousand And One Amino Acid Protein Kinase 1 (TAOK1) ELISA Kit Customized Service Offer
  1. "Comparative studies of a new subfamily of human Ste20-like kinases: homodimerization, subcellular localization, and selective activation of MKK3 and p38."Oncogene 22:6129-6141(2003) [PubMed] [Europe PMC] [Abstract]
  2. "T cell activating gene."Patent number WO2004058805, 15-JUL-2004
  3. "Prediction of the coding sequences of unidentified human genes. XVI. The complete sequences of 150 new cDNA clones from brain which code for large proteins in vitro."DNA Res. 7:65-73(2000) [PubMed] [Europe PMC] [Abstract]
  4. "Complete sequencing and characterization of 21,243 full-length human cDNAs." Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract]
  5. "DNA sequence of human chromosome 17 and analysis of rearrangement in the human lineage." Nature 440:1045-1049(2006) [PubMed] [Europe PMC] [Abstract]
  6. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
  7. "Isolation of TAO1, a protein kinase that activates MEKs in stress-activated protein kinase cascades."J. Biol. Chem. 273:28625-28632(1998) [PubMed] [Europe PMC] [Abstract]
  8. "TAO (thousand-and-one amino acid) protein kinases mediate signaling from carbachol to p38 mitogen-activated protein kinase and ternary complex factors."J. Biol. Chem. 278:22278-22283(2003) [PubMed] [Europe PMC] [Abstract]
  9. "Prostate-derived sterile 20-like kinase 2 (PSK2) regulates apoptotic morphology via C-Jun N-terminal kinase and Rho kinase-1."J. Biol. Chem. 281:7317-7323(2006) [PubMed] [Europe PMC] [Abstract]
  10. "Osmotic stress activates the TAK1-JNK pathway while blocking TAK1-mediated NF-kappaB activation: TAO2 regulates TAK1 pathways."J. Biol. Chem. 281:28802-28810(2006) [PubMed] [Europe PMC] [Abstract]
  11. "A probability-based approach for high-throughput protein phosphorylation analysis and site localization."Nat. Biotechnol. 24:1285-1292(2006) [PubMed] [Europe PMC] [Abstract]
  12. "TAO kinases mediate activation of p38 in response to DNA damage."EMBO J. 26:2005-2014(2007) [PubMed] [Europe PMC] [Abstract]
  13. "A functional genomic screen identifies a role for TAO1 kinase in spindle-checkpoint signalling."Nat. Cell Biol. 9:556-564(2007) [PubMed] [Europe PMC] [Abstract]
  14. "Human TAO kinase 1 induces apoptosis in SH-SY5Y cells."Cell Biol. Int. 32:151-156(2008) [PubMed] [Europe PMC] [Abstract]
  15. "Phosphoproteome of resting human platelets."J. Proteome Res. 7:526-534(2008) [PubMed] [Europe PMC] [Abstract]
  16. "Kinase-selective enrichment enables quantitative phosphoproteomics of the kinome across the cell cycle."Mol. Cell 31:438-448(2008) [PubMed] [Europe PMC] [Abstract]
  17. "A quantitative atlas of mitotic phosphorylation."Proc. Natl. Acad. Sci. U.S.A. 105:10762-10767(2008) [PubMed] [Europe PMC] [Abstract]
  18. "Lys-N and trypsin cover complementary parts of the phosphoproteome in a refined SCX-based approach."Anal. Chem. 81:4493-4501(2009) [PubMed] [Europe PMC] [Abstract]
  19. "Large-scale proteomics analysis of the human kinome."Mol. Cell. Proteomics 8:1751-1764(2009) [PubMed] [Europe PMC] [Abstract]
  20. "Quantitative phosphoproteomic analysis of T cell receptor signaling reveals system-wide modulation of protein-protein interactions."Sci. Signal. 2:RA46-RA46(2009) [PubMed] [Europe PMC] [Abstract]
  21. "Re-examination of siRNA specificity questions role of PICH and Tao1 in the spindle checkpoint and identifies Mad2 as a sensitive target for small RNAs."Chromosoma 119:149-165(2010) [PubMed] [Europe PMC] [Abstract]
  22. "Re-evaluating the role of Tao1 in the spindle checkpoint."Chromosoma 119:371-379(2010) [PubMed] [Europe PMC] [Abstract]
  23. "Signal transduction protein array analysis links LRRK2 to Ste20 kinases and PKC zeta that modulate neuronal plasticity."PLoS ONE 5:E13191-E13191(2010) [PubMed] [Europe PMC] [Abstract]
  24. "Initial characterization of the human central proteome."BMC Syst. Biol. 5:17-17(2011) [PubMed] [Europe PMC] [Abstract]
  25. "System-wide temporal characterization of the proteome and phosphoproteome of human embryonic stem cell differentiation."Sci. Signal. 4:RS3-RS3(2011) [PubMed] [Europe PMC] [Abstract]
  26. "An enzyme assisted RP-RPLC approach for in-depth analysis of human liver phosphoproteome."J. Proteomics 96:253-262(2014) [PubMed] [Europe PMC] [Abstract]
  27. "Patterns of somatic mutation in human cancer genomes." Nature 446:153-158(2007) [PubMed] [Europe PMC] [Abstract]