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Synaptojanin 1 (SYNJ1)

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INPP5G; Synaptic inositol 1,4,5-trisphosphate 5-phosphatase 1

Synaptojanin 1 (SYNJ1)
CCC H085
HGNC 11503
MGI 1354961
PubMed 23804577
RGD 69434
UniProt O43426
Synaptojanin-1 is a phosphatidylinositol (4,5)-bisphosphate (PI(4,5)P2) that has a role in clathrin-coated pit dynamics. The authors found that synaptojanin-170, an alternatively spliced isoform of SYNJ1, binds EPS15 , a clathrin coat-associated protein. Binding was mediated by the C-terminal region of synaptojanin-170, which contains 3 asparagine-proline-phenylalanine (NPF) repeats.
This motif had been found to be the core of the binding site for the EH domains of EPS15. These findings suggested that SYNJ1 can be recruited to clathrin-coated pits via a multiplicity of interactions.These Synj1-deficient mice exhibited neurologic defects and died shortly after birth.

Organism species: Homo sapiens (Human)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins n/a Recombinant Synaptojanin 1 (SYNJ1) Recombinant Protein Customized Service Offer
Antibodies n/a Monoclonal Antibody to Synaptojanin 1 (SYNJ1) Monoclonal Antibody Customized Service Offer
n/a Polyclonal Antibody to Synaptojanin 1 (SYNJ1) Polyclonal Antibody Customized Service Offer
Assay Kits n/a CLIA Kit for Synaptojanin 1 (SYNJ1) CLIA Kit Customized Service Offer
n/a ELISA Kit for Synaptojanin 1 (SYNJ1) ELISA Kit Customized Service Offer

Organism species: Mus musculus (Mouse)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins n/a Recombinant Synaptojanin 1 (SYNJ1) Recombinant Protein Customized Service Offer
Antibodies n/a Monoclonal Antibody to Synaptojanin 1 (SYNJ1) Monoclonal Antibody Customized Service Offer
n/a Polyclonal Antibody to Synaptojanin 1 (SYNJ1) Polyclonal Antibody Customized Service Offer
Assay Kits n/a CLIA Kit for Synaptojanin 1 (SYNJ1) CLIA Kit Customized Service Offer
n/a ELISA Kit for Synaptojanin 1 (SYNJ1) ELISA Kit Customized Service Offer

Organism species: Rattus norvegicus (Rat)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins n/a Recombinant Synaptojanin 1 (SYNJ1) Recombinant Protein Customized Service Offer
Antibodies n/a Monoclonal Antibody to Synaptojanin 1 (SYNJ1) Monoclonal Antibody Customized Service Offer
n/a Polyclonal Antibody to Synaptojanin 1 (SYNJ1) Polyclonal Antibody Customized Service Offer
Assay Kits n/a CLIA Kit for Synaptojanin 1 (SYNJ1) CLIA Kit Customized Service Offer
n/a ELISA Kit for Synaptojanin 1 (SYNJ1) ELISA Kit Customized Service Offer
  1. "Synaptojanin 1: localization on coated endocytic intermediates in nerve terminals and interaction of its 170 kDa isoform with Eps15."FEBS Lett. 419:175-180(1997) [PubMed] [Europe PMC] [Abstract]
  2. "Prediction of the coding sequences of unidentified human genes. XII. The complete sequences of 100 new cDNA clones from brain which code for large proteins in vitro."DNA Res. 5:355-364(1998) [PubMed] [Europe PMC] [Abstract]
  3. "Construction of expression-ready cDNA clones for KIAA genes: manual curation of 330 KIAA cDNA clones."DNA Res. 9:99-106(2002) [PubMed] [Europe PMC] [Abstract]
  4. "The DNA sequence of human chromosome 21." Nature 405:311-319(2000) [PubMed] [Europe PMC] [Abstract]
  5. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
  6. "The SH3 domains of endophilin and amphiphysin bind to the proline-rich region of synaptojanin 1 at distinct sites that display an unconventional binding specificity."J. Biol. Chem. 274:32001-32007(1999) [PubMed] [Europe PMC] [Abstract]
  7. "Myosin 1E interacts with synaptojanin-1 and dynamin and is involved in endocytosis."FEBS Lett. 581:644-650(2007) [PubMed] [Europe PMC] [Abstract]
  8. "A quantitative atlas of mitotic phosphorylation."Proc. Natl. Acad. Sci. U.S.A. 105:10762-10767(2008) [PubMed] [Europe PMC] [Abstract]
  9. "Quantitative phosphoproteomic analysis of T cell receptor signaling reveals system-wide modulation of protein-protein interactions."Sci. Signal. 2:RA46-RA46(2009) [PubMed] [Europe PMC] [Abstract]
  10. "Quantitative phosphoproteomics reveals widespread full phosphorylation site occupancy during mitosis."Sci. Signal. 3:RA3-RA3(2010) [PubMed] [Europe PMC] [Abstract]
  11. "An enzyme assisted RP-RPLC approach for in-depth analysis of human liver phosphoproteome."J. Proteomics 96:253-262(2014) [PubMed] [Europe PMC] [Abstract]
  12. "Solution structure of RNA binding domain in synaptojanin 1."Submitted (OCT-2006) to the PDB data bank
  13. "The Sac1 domain of SYNJ1 identified mutated in a family with early-onset progressive Parkinsonism with generalized seizures."Hum. Mutat. 34:1200-1207(2013) [PubMed] [Europe PMC] [Abstract]
  14. "Mutation in the SYNJ1 gene associated with autosomal recessive, early-onset Parkinsonism."Hum. Mutat. 34:1208-1215(2013) [PubMed] [Europe PMC] [Abstract]