Sulfotransferase Family 4A, Member 1 (SULT4A1)

SULT4A1 is involved in the metabolism of endogenous chemicals, such as thyroid hormones, steroids, and monoamine neurotransmitters, as well as drugs and xenobiotics. Conjugation with a charged sulfonate moiety usually decreases the biologic activity of the compound and increases its aqueous solubility and excretion.The deduced 284-amino acid SULT4A1 protein has a calculated molecular mass of about 33.1 kD. It contains an N-terminal 3-prime-phosphoadenosine 5-prime-phosphosulfate (PAPS)-binding site, a putative active-site histidine (his111), and a central motif involved in PAPS binding. SULT4A1 shares 30% to 36% amino acid identity with several other sulfotransferases. SULT4A1 expression in brain, but not in heart, placenta, lung, liver, skeletal muscle, kidney, or pancreas.