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Serine/Threonine Kinase 3 (STK3)

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KRS1; MST2; Mammalian STE20-like protein kinase 2; STE20-like kinase MST2; Serine/threonine-protein kinase Krs-1

Serine/Threonine Kinase 3 (STK3)
CCC H119
HGNC 11406
MGI 1928487
PubMed 8816758
RGD 68412
UniProt Q13188
Wiki MST2
Protein kinase activation is a frequent response of cells to treatment with growth factors, chemicals, heat shock, or apoptosis-inducing agents. This protein kinase activation presumably allows cells to resist unfavorable environmental conditions. The yeast 'sterile 20' (Ste20) kinase acts upstream of the mitogen-activated protein kinase (MAPK) cascade that is activated under a variety of stress conditions. MST2 was identified as a kinase that is activated by the proapoptotic agents straurosporine and FAS ligand. Sequence analysis indicated that, like STK4, the deduced 491-amino acid STK3 protein contains an N-terminal catalytic domain characteristic of STKs. This N-terminal domain is nearly identical to that of STK4, but the C terminus shares only 60% amino acid identity.

Organism species: Homo sapiens (Human)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins n/a Recombinant Serine/Threonine Kinase 3 (STK3) Recombinant Protein Customized Service Offer
Antibodies n/a Monoclonal Antibody to Serine/Threonine Kinase 3 (STK3) Monoclonal Antibody Customized Service Offer
n/a Polyclonal Antibody to Serine/Threonine Kinase 3 (STK3) Polyclonal Antibody Customized Service Offer
Assay Kits n/a CLIA Kit for Serine/Threonine Kinase 3 (STK3) CLIA Kit Customized Service Offer
n/a ELISA Kit for Serine/Threonine Kinase 3 (STK3) ELISA Kit Customized Service Offer

Organism species: Mus musculus (Mouse)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins RPH119Mu01 Recombinant Serine/Threonine Kinase 3 (STK3) Positive Control; Immunogen; SDS-PAGE; WB.
RPH119Mu02 Recombinant Serine/Threonine Kinase 3 (STK3) Positive Control; Immunogen; SDS-PAGE; WB.
Antibodies PAH119Mu01 Polyclonal Antibody to Serine/Threonine Kinase 3 (STK3) WB; IHC; ICC; IP.
PAH119Mu02 Polyclonal Antibody to Serine/Threonine Kinase 3 (STK3) WB; IHC; ICC; IP.
Assay Kits n/a CLIA Kit for Serine/Threonine Kinase 3 (STK3) CLIA Kit Customized Service Offer
n/a ELISA Kit for Serine/Threonine Kinase 3 (STK3) ELISA Kit Customized Service Offer

Organism species: Rattus norvegicus (Rat)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins n/a Recombinant Serine/Threonine Kinase 3 (STK3) Recombinant Protein Customized Service Offer
Antibodies n/a Monoclonal Antibody to Serine/Threonine Kinase 3 (STK3) Monoclonal Antibody Customized Service Offer
n/a Polyclonal Antibody to Serine/Threonine Kinase 3 (STK3) Polyclonal Antibody Customized Service Offer
Assay Kits n/a CLIA Kit for Serine/Threonine Kinase 3 (STK3) CLIA Kit Customized Service Offer
n/a ELISA Kit for Serine/Threonine Kinase 3 (STK3) ELISA Kit Customized Service Offer
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  2. "Newly identified stress-responsive protein kinases, Krs-1 and Krs-2."Proc. Natl. Acad. Sci. U.S.A. 93:10099-10104(1996) [PubMed] [Europe PMC] [Abstract]
  3. "Complete sequencing and characterization of 21,243 full-length human cDNAs." Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract]
  4. "DNA sequence and analysis of human chromosome 8." Nature 439:331-335(2006) [PubMed] [Europe PMC] [Abstract]
  5. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
  6. , Submitted (JUL-2007) to UniProtKB
  7. "Identification of 21 novel human protein kinases, including 3 members of a family related to the cell cycle regulator nimA of Aspergillus nidulans."Cell Growth Differ. 4:821-830(1993) [PubMed] [Europe PMC] [Abstract]
  8. "MST, a physiological caspase substrate, highly sensitizes apoptosis both upstream and downstream of caspase activation."J. Biol. Chem. 276:19276-19285(2001) [PubMed] [Europe PMC] [Abstract]
  9. "Role of the kinase MST2 in suppression of apoptosis by the proto-oncogene product Raf-1."Science 306:2267-2270(2004) [PubMed] [Europe PMC] [Abstract]
  10. "The Ste20-like kinase Mst2 activates the human large tumor suppressor kinase Lats1."Oncogene 24:2076-2086(2005) [PubMed] [Europe PMC] [Abstract]
  11. "Role of the tumor suppressor RASSF1A in Mst1-mediated apoptosis."Cancer Res. 66:2562-2569(2006) [PubMed] [Europe PMC] [Abstract]
  12. "Association of mammalian sterile twenty kinases, Mst1 and Mst2, with hSalvador via C-terminal coiled-coil domains, leads to its stabilization and phosphorylation."FEBS J. 273:4264-4276(2006) [PubMed] [Europe PMC] [Abstract]
  13. "MOBKL1A/MOBKL1B phosphorylation by MST1 and MST2 inhibits cell proliferation."Curr. Biol. 18:311-321(2008) [PubMed] [Europe PMC] [Abstract]
  14. "Kinase-selective enrichment enables quantitative phosphoproteomics of the kinome across the cell cycle."Mol. Cell 31:438-448(2008) [PubMed] [Europe PMC] [Abstract]
  15. "Threonine 74 of MOB1 is a putative key phosphorylation site by MST2 to form the scaffold to activate nuclear Dbf2-related kinase 1."Oncogene 27:4281-4292(2008) [PubMed] [Europe PMC] [Abstract]
  16. "A quantitative atlas of mitotic phosphorylation."Proc. Natl. Acad. Sci. U.S.A. 105:10762-10767(2008) [PubMed] [Europe PMC] [Abstract]
  17. "Lys-N and trypsin cover complementary parts of the phosphoproteome in a refined SCX-based approach."Anal. Chem. 81:4493-4501(2009) [PubMed] [Europe PMC] [Abstract]
  18. "Mammalian NDR/LATS protein kinases in hippo tumor suppressor signaling."BioFactors 35:338-345(2009) [PubMed] [Europe PMC] [Abstract]
  19. "Large-scale proteomics analysis of the human kinome."Mol. Cell. Proteomics 8:1751-1764(2009) [PubMed] [Europe PMC] [Abstract]
  20. "RASSF2 associates with and stabilizes the proapoptotic kinase MST2."Oncogene 28:2988-2998(2009) [PubMed] [Europe PMC] [Abstract]
  21. "Quantitative phosphoproteomic analysis of T cell receptor signaling reveals system-wide modulation of protein-protein interactions."Sci. Signal. 2:RA46-RA46(2009) [PubMed] [Europe PMC] [Abstract]
  22. "Proapoptotic kinase MST2 coordinates signaling crosstalk between RASSF1A, Raf-1, and Akt."Cancer Res. 70:1195-1203(2010) [PubMed] [Europe PMC] [Abstract]
  23. "Mammalian Ste20-like kinase (Mst2) indirectly supports Raf-1/ERK pathway activity via maintenance of protein phosphatase-2A catalytic subunit levels and consequent suppression of inhibitory Raf-1 phosphorylation."J. Biol. Chem. 285:15076-15087(2010) [PubMed] [Europe PMC] [Abstract]
  24. "Components of the Hippo pathway cooperate with Nek2 kinase to regulate centrosome disjunction."Nat. Cell Biol. 12:1166-1176(2010) [PubMed] [Europe PMC] [Abstract]
  25. "Regulation of proapoptotic mammalian ste20-like kinase MST2 by the IGF1-Akt pathway."PLoS ONE 5:E9616-E9616(2010) [PubMed] [Europe PMC] [Abstract]
  26. "Initial characterization of the human central proteome."BMC Syst. Biol. 5:17-17(2011) [PubMed] [Europe PMC] [Abstract]
  27. "The tumor suppressor RASSF1A prevents dephosphorylation of the mammalian STE20-like kinases MST1 and MST2."J. Biol. Chem. 286:6253-6261(2011) [PubMed] [Europe PMC] [Abstract]
  28. "Mammalian MST2 kinase and human Salvador activate and reduce estrogen receptor alpha in the absence of ligand."J. Mol. Med. 89:181-191(2011) [PubMed] [Europe PMC] [Abstract]
  29. "System-wide temporal characterization of the proteome and phosphoproteome of human embryonic stem cell differentiation."Sci. Signal. 4:RS3-RS3(2011) [PubMed] [Europe PMC] [Abstract]
  30. "Patterns of somatic mutation in human cancer genomes." Nature 446:153-158(2007) [PubMed] [Europe PMC] [Abstract]