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Serine Palmitoyltransferase, Long Chain Base Subunit 2 (SPTLC2)

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LCB2; SPT2; Long chain base biosynthesis protein 2; Serine-palmitoyl-CoA transferase 2

Serine Palmitoyltransferase, Long Chain Base Subunit 2 (SPTLC2)
CCC H137
HGNC 11278
MGI 108074
PubMed 20920666
RGD 1305447
UniProt O15270
Wiki SPTLC2
Serine palmitoyltransferase (SPT; EC 2.3.1.50) is the key enzyme in sphingolipid biosynthesis. It catalyzes the pyridoxal-5-prime-phosphate-dependent condensation of L-serine and palmitoyl-CoA to 3-oxosphinganine.
SPTLC2encodes a long chain base subunit of serine palmitoyltransferase. Serine palmitoyltransferase, which consists of two different subunits, is the initial enzyme in sphingolipid biosynthesis. It catalyzes the pyridoxal 5'-phosphate dependent condensation of L-serine and palmitoyl CoA to 3-oxosphinganine. Mutations in this gene were identified in patients with hereditary sensory neuropathy type I. Alternatively spliced variants encoding different isoforms have been identified.The LCB2 cDNA encodes a protein of 562 amino acids that is more than 90% identical to the mouse protein.

Organism species: Homo sapiens (Human)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins n/a Recombinant Serine Palmitoyltransferase, Long Chain Base Subunit 2 (SPTLC2) Recombinant Protein Customized Service Offer
Antibodies n/a Monoclonal Antibody to Serine Palmitoyltransferase, Long Chain Base Subunit 2 (SPTLC2) Monoclonal Antibody Customized Service Offer
n/a Polyclonal Antibody to Serine Palmitoyltransferase, Long Chain Base Subunit 2 (SPTLC2) Polyclonal Antibody Customized Service Offer
Assay Kits n/a CLIA Kit for Serine Palmitoyltransferase, Long Chain Base Subunit 2 (SPTLC2) CLIA Kit Customized Service Offer
n/a ELISA Kit for Serine Palmitoyltransferase, Long Chain Base Subunit 2 (SPTLC2) ELISA Kit Customized Service Offer

Organism species: Mus musculus (Mouse)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins RPH137Mu01 Recombinant Serine Palmitoyltransferase, Long Chain Base Subunit 2 (SPTLC2) Positive Control; Immunogen; SDS-PAGE; WB.
RPH137Mu02 Recombinant Serine Palmitoyltransferase, Long Chain Base Subunit 2 (SPTLC2) Positive Control; Immunogen; SDS-PAGE; WB.
Antibodies PAH137Mu01 Polyclonal Antibody to Serine Palmitoyltransferase, Long Chain Base Subunit 2 (SPTLC2) WB; IHC; ICC; IP.
PAH137Mu02 Polyclonal Antibody to Serine Palmitoyltransferase, Long Chain Base Subunit 2 (SPTLC2) WB; IHC; ICC; IP.
Assay Kits SEH137Mu ELISA Kit for Serine Palmitoyltransferase, Long Chain Base Subunit 2 (SPTLC2) Enzyme-linked immunosorbent assay for Antigen Detection.

Organism species: Rattus norvegicus (Rat)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins n/a Recombinant Serine Palmitoyltransferase, Long Chain Base Subunit 2 (SPTLC2) Recombinant Protein Customized Service Offer
Antibodies n/a Monoclonal Antibody to Serine Palmitoyltransferase, Long Chain Base Subunit 2 (SPTLC2) Monoclonal Antibody Customized Service Offer
n/a Polyclonal Antibody to Serine Palmitoyltransferase, Long Chain Base Subunit 2 (SPTLC2) Polyclonal Antibody Customized Service Offer
Assay Kits n/a CLIA Kit for Serine Palmitoyltransferase, Long Chain Base Subunit 2 (SPTLC2) CLIA Kit Customized Service Offer
n/a ELISA Kit for Serine Palmitoyltransferase, Long Chain Base Subunit 2 (SPTLC2) ELISA Kit Customized Service Offer
  1. "Human and murine serine-palmitoyl-CoA transferase. Cloning, expression and characterization of the key enzyme in sphingolipid synthesis."Eur. J. Biochem. 249:239-247(1997) [PubMed] [Europe PMC] [Abstract]
  2. "Prediction of the coding sequences of unidentified human genes. IX. The complete sequences of 100 new cDNA clones from brain which can code for large proteins in vitro."DNA Res. 5:31-39(1998) [PubMed] [Europe PMC] [Abstract]
  3. "The DNA sequence and analysis of human chromosome 14." Nature 421:601-607(2003) [PubMed] [Europe PMC] [Abstract]
  4. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
  5. "Sphingolipid synthesis: identification and characterization of mammalian cDNAs encoding the Lcb2 subunit of serine palmitoyltransferase."Gene 177:237-241(1996) [PubMed] [Europe PMC] [Abstract]
  6. "A molecular inventory of human pancreatic islets: sequence analysis of 1000 cDNA clones."Hum. Mol. Genet. 2:1793-1798(1993) [PubMed] [Europe PMC] [Abstract]
  7. "Cloning and initial characterization of a new subunit for mammalian serine-palmitoyltransferase."J. Biol. Chem. 281:37275-37281(2006) [PubMed] [Europe PMC] [Abstract]
  8. "Identification of small subunits of mammalian serine palmitoyltransferase that confer distinct acyl-CoA substrate specificities."Proc. Natl. Acad. Sci. U.S.A. 106:8186-8191(2009) [PubMed] [Europe PMC] [Abstract]
  9. "Mutations in the SPTLC2 subunit of serine palmitoyltransferase cause hereditary sensory and autonomic neuropathy type I."Am. J. Hum. Genet. 87:513-522(2010) [PubMed] [Europe PMC] [Abstract]
  10. "Initial characterization of the human central proteome."BMC Syst. Biol. 5:17-17(2011) [PubMed] [Europe PMC] [Abstract]
  11. "Hereditary sensory and autonomic neuropathy type 1 (HSANI) caused by a novel mutation in SPTLC2."Neurology 80:2106-2111(2013) [PubMed] [Europe PMC] [Abstract]