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Sepiapterin Reductase (SPR)

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SDR38C1; 7,8-Dihydrobiopterin:NADP+ Oxidoreductase; Short Chain Dehydrogenase/Reductase Family 38C,Member 1

Sepiapterin Reductase (SPR)
CCC H139
HGNC 11257
MGI 103078
PubMed 1883349
RGD 3753
UniProt P35270
Wiki SPR
Sepiapterin reductase (7,8-dihydrobiopterin:NADP+ oxidoreductase; EC 1.1.1.153) catalyzes the NADPH-dependent reduction of various carbonyl substances, including derivatives of pteridines, and belongs to a group of enzymes called aldo-keto reductases. SPR plays an important role in the biosynthesis of tetrahydrobiopterin (BH4).
The clone encoded a protein of 261 amino acids with a calculated molecular mass of 28,047 Da. The predicted amino acid sequence of human sepiapterin reductase shows 74% identity with the rat enzyme and a striking homology with human carbonyl reductase, estradiol 17-beta-dehydrogenase, and 3-beta-hydroxy-5-ene steroid dehydrogenase, especially in the N-terminal region.

Organism species: Homo sapiens (Human)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins RPH139Hu01 Recombinant Sepiapterin Reductase (SPR) Positive Control; Immunogen; SDS-PAGE; WB.
Antibodies PAH139Hu01 Polyclonal Antibody to Sepiapterin Reductase (SPR) WB; IHC; ICC; IP.
MAH139Hu21 Monoclonal Antibody to Sepiapterin Reductase (SPR) WB; IHC; ICC; IP.
Assay Kits SEH139Hu ELISA Kit for Sepiapterin Reductase (SPR) Enzyme-linked immunosorbent assay for Antigen Detection.

Organism species: Mus musculus (Mouse)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins RPH139Mu01 Recombinant Sepiapterin Reductase (SPR) Positive Control; Immunogen; SDS-PAGE; WB.
RPH139Mu02 Recombinant Sepiapterin Reductase (SPR) Positive Control; Immunogen; SDS-PAGE; WB.
Antibodies PAH139Mu01 Polyclonal Antibody to Sepiapterin Reductase (SPR) WB; IHC; ICC; IP.
PAH139Mu02 Polyclonal Antibody to Sepiapterin Reductase (SPR) WB; IHC; ICC; IP.
Assay Kits SEH139Mu ELISA Kit for Sepiapterin Reductase (SPR) Enzyme-linked immunosorbent assay for Antigen Detection.

Organism species: Rattus norvegicus (Rat)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins n/a Recombinant Sepiapterin Reductase (SPR) Recombinant Protein Customized Service Offer
Antibodies n/a Monoclonal Antibody to Sepiapterin Reductase (SPR) Monoclonal Antibody Customized Service Offer
n/a Polyclonal Antibody to Sepiapterin Reductase (SPR) Polyclonal Antibody Customized Service Offer
Assay Kits n/a CLIA Kit for Sepiapterin Reductase (SPR) CLIA Kit Customized Service Offer
n/a ELISA Kit for Sepiapterin Reductase (SPR) ELISA Kit Customized Service Offer
  1. "Cloning and sequencing of cDNA encoding human sepiapterin reductase -- an enzyme involved in tetrahydrobiopterin biosynthesis."Biochem. Biophys. Res. Commun. 179:183-189(1991) [PubMed] [Europe PMC] [Abstract]
  2. "Detection of a novel sepiapterin reductase mRNA: assay of mRNA in various cells and tissues of various species."Exp. Cell Res. 204:217-222(1993) [PubMed] [Europe PMC] [Abstract]
  3. "Complete sequencing and characterization of 21,243 full-length human cDNAs." Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract]
  4. "Generation and annotation of the DNA sequences of human chromosomes 2 and 4." Nature 434:724-731(2005) [PubMed] [Europe PMC] [Abstract]
  5. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
  6. "Genomic organization and chromosomal localization of the human sepiapterin reductase gene."Biochem. Biophys. Res. Commun. 251:597-602(1998) [PubMed] [Europe PMC] [Abstract]
  7. "Mutational analysis of sites in sepiapterin reductase phosphorylated by Ca2+/calmodulin-dependent protein kinase II."Biochim. Biophys. Acta 1594:191-198(2002) [PubMed] [Europe PMC] [Abstract]
  8. "Initial characterization of the human central proteome."BMC Syst. Biol. 5:17-17(2011) [PubMed] [Europe PMC] [Abstract]
  9. "An enzyme assisted RP-RPLC approach for in-depth analysis of human liver phosphoproteome."J. Proteomics 96:253-262(2014) [PubMed] [Europe PMC] [Abstract]
  10. "Crystal structure of human sepiapterin reductase."Submitted (FEB-2009) to the PDB data bank
  11. "Mutations in the sepiapterin reductase gene cause a novel tetrahydrobiopterin-dependent monoamine-neurotransmitter deficiency without hyperphenylalaninemia."Am. J. Hum. Genet. 69:269-277(2001) [PubMed] [Europe PMC] [Abstract]
  12. "Sepiapterin reductase deficiency an autosomal recessive DOPA-responsive dystonia."Mol. Genet. Metab. 89:116-120(2006) [PubMed] [Europe PMC] [Abstract]
  13. "Dopa-responsive hypersomnia and mixed movement disorder due to sepiapterin reductase deficiency."Neurology 67:2032-2035(2006) [PubMed] [Europe PMC] [Abstract]