Small Nuclear Ribonucleoprotein 70kDa (SNRNP70)

[Edit]

RNPU1Z; RPU1; U170K; U1AP; U1RNP; Autoantigen U1-RNP

Small Nuclear Ribonucleoprotein 70kDa (SNRNP70)

SNRP70 gene is greater than 44 kb, with 11 exons. SNRP70 gene is present in single copy, consists of 6 exons, and is 14 to 16 kb long.The series of reactions leading to the removal of intervening sequences from pre-mRNAs to yield mature mRNA occurs in a complex known as the spliceosome. The spliceosome contains several small nuclear ribonucleoprotein complexes (snRNPs). One of these, the U1 snRNP, contains at least 3 specific proteins. The protein contains 3 regions similar to known nucleic acid-binding proteins, and bound RNA in an in vitro assay. Multiple forms due to alternative splicing may exist, possibly with different functions in vivo. The human U1-70K snRNP protein is the major antigen recognized by anti-(U1)RNP sera from patients with autoimmune diseases.

Organism species: Homo sapiens (Human)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins RPH160Hu01 Recombinant Small Nuclear Ribonucleoprotein 70kDa (SNRNP70) Positive Control; Immunogen; SDS-PAGE; WB.
RPH160Hu02 Recombinant Small Nuclear Ribonucleoprotein 70kDa (SNRNP70) Positive Control; Immunogen; SDS-PAGE; WB.
Antibodies n/a Monoclonal Antibody to Small Nuclear Ribonucleoprotein 70kDa (SNRNP70) Monoclonal Antibody Customized Service Offer
n/a Polyclonal Antibody to Small Nuclear Ribonucleoprotein 70kDa (SNRNP70) Polyclonal Antibody Customized Service Offer
Assay Kits n/a CLIA Kit for Small Nuclear Ribonucleoprotein 70kDa (SNRNP70) CLIA Kit Customized Service Offer
n/a ELISA Kit for Small Nuclear Ribonucleoprotein 70kDa (SNRNP70) ELISA Kit Customized Service Offer

Organism species: Mus musculus (Mouse)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins n/a Recombinant Small Nuclear Ribonucleoprotein 70kDa (SNRNP70) Recombinant Protein Customized Service Offer
Antibodies n/a Monoclonal Antibody to Small Nuclear Ribonucleoprotein 70kDa (SNRNP70) Monoclonal Antibody Customized Service Offer
n/a Polyclonal Antibody to Small Nuclear Ribonucleoprotein 70kDa (SNRNP70) Polyclonal Antibody Customized Service Offer
Assay Kits n/a CLIA Kit for Small Nuclear Ribonucleoprotein 70kDa (SNRNP70) CLIA Kit Customized Service Offer
n/a ELISA Kit for Small Nuclear Ribonucleoprotein 70kDa (SNRNP70) ELISA Kit Customized Service Offer

Organism species: Rattus norvegicus (Rat)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins n/a Recombinant Small Nuclear Ribonucleoprotein 70kDa (SNRNP70) Recombinant Protein Customized Service Offer
Antibodies n/a Monoclonal Antibody to Small Nuclear Ribonucleoprotein 70kDa (SNRNP70) Monoclonal Antibody Customized Service Offer
n/a Polyclonal Antibody to Small Nuclear Ribonucleoprotein 70kDa (SNRNP70) Polyclonal Antibody Customized Service Offer
Assay Kits n/a CLIA Kit for Small Nuclear Ribonucleoprotein 70kDa (SNRNP70) CLIA Kit Customized Service Offer
n/a ELISA Kit for Small Nuclear Ribonucleoprotein 70kDa (SNRNP70) ELISA Kit Customized Service Offer
  1. "Cloning of the human cDNA for the U1 RNA-associated 70K protein."EMBO J. 5:3209-3217(1986) [PubMed] [Europe PMC] [Abstract]
  2. "The human U1-70K snRNP protein: cDNA cloning, chromosomal localization, expression, alternative splicing and RNA-binding."Nucleic Acids Res. 15:10373-10391(1987) [PubMed] [Europe PMC] [Abstract]
  3. "A common RNA recognition motif identified within a defined U1 RNA binding domain of the 70K U1 snRNP protein."Cell 57:89-101(1989) [PubMed] [Europe PMC] [Abstract]
  4. "Human U1-70K ribonucleoprotein antigen gene: organization, nucleotide sequence, and mapping to locus 19q13.3."Genomics 8:371-379(1990) [PubMed] [Europe PMC] [Abstract]
  5. "Identification of an inhibitory element within the human 68-kDa (U1) ribonucleoprotein antigen."Protein Expr. Purif. 6:748-756(1995) [PubMed] [Europe PMC] [Abstract]
  6. "Complete sequencing and characterization of 21,243 full-length human cDNAs." Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract]
  7. "The full-ORF clone resource of the German cDNA consortium."BMC Genomics 8:399-399(2007) [PubMed] [Europe PMC] [Abstract]
  8. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
  9. "Identification of an snRNP-associated kinase activity that phosphorylates arginine/serine rich domains typical of splicing factors."Nucleic Acids Res. 21:2815-2822(1993) [PubMed] [Europe PMC] [Abstract]
  10. "A coactivator of pre-mRNA splicing."Genes Dev. 12:996-1009(1998) [PubMed] [Europe PMC] [Abstract]
  11. "Sip1, a novel RS domain-containing protein essential for pre-mRNA splicing."Mol. Cell. Biol. 18:676-684(1998) [PubMed] [Europe PMC] [Abstract]
  12. "The SRm160/300 splicing coactivator is required for exon-enhancer function."Proc. Natl. Acad. Sci. U.S.A. 96:6125-6130(1999) [PubMed] [Europe PMC] [Abstract]
  13. "ZNF265 -- a novel spliceosomal protein able to induce alternative splicing."J. Cell Biol. 154:25-32(2001) [PubMed] [Europe PMC] [Abstract]
  14. "Nuclear relocalization of the pre-mRNA splicing factor PSF during apoptosis involves hyperphosphorylation, masking of antigenic epitopes, and changes in protein interactions."Mol. Biol. Cell 12:2328-2340(2001) [PubMed] [Europe PMC] [Abstract]
  15. "Association of polyadenylation cleavage factor I with U1 snRNP."RNA 9:1400-1409(2003) [PubMed] [Europe PMC] [Abstract]
  16. "Robust phosphoproteomic profiling of tyrosine phosphorylation sites from human T cells using immobilized metal affinity chromatography and tandem mass spectrometry."Anal. Chem. 76:2763-2772(2004) [PubMed] [Europe PMC] [Abstract]
  17. "Dephosphorylated SRp38 acts as a splicing repressor in response to heat shock."Nature 427:553-558(2004) [PubMed] [Europe PMC] [Abstract]
  18. "Global, in vivo, and site-specific phosphorylation dynamics in signaling networks."Cell 127:635-648(2006) [PubMed] [Europe PMC] [Abstract]
  19. "A probability-based approach for high-throughput protein phosphorylation analysis and site localization."Nat. Biotechnol. 24:1285-1292(2006) [PubMed] [Europe PMC] [Abstract]
  20. "Improved titanium dioxide enrichment of phosphopeptides from HeLa cells and high confident phosphopeptide identification by cross-validation of MS/MS and MS/MS/MS spectra."J. Proteome Res. 6:4150-4162(2007) [PubMed] [Europe PMC] [Abstract]
  21. "Kinase-selective enrichment enables quantitative phosphoproteomics of the kinome across the cell cycle."Mol. Cell 31:438-448(2008) [PubMed] [Europe PMC] [Abstract]
  22. "A quantitative atlas of mitotic phosphorylation."Proc. Natl. Acad. Sci. U.S.A. 105:10762-10767(2008) [PubMed] [Europe PMC] [Abstract]
  23. "Lys-N and trypsin cover complementary parts of the phosphoproteome in a refined SCX-based approach."Anal. Chem. 81:4493-4501(2009) [PubMed] [Europe PMC] [Abstract]
  24. "Large-scale proteomics analysis of the human kinome."Mol. Cell. Proteomics 8:1751-1764(2009) [PubMed] [Europe PMC] [Abstract]
  25. "Quantitative phosphoproteomic analysis of T cell receptor signaling reveals system-wide modulation of protein-protein interactions."Sci. Signal. 2:RA46-RA46(2009) [PubMed] [Europe PMC] [Abstract]
  26. "Lysine acetylation targets protein complexes and co-regulates major cellular functions."Science 325:834-840(2009) [PubMed] [Europe PMC] [Abstract]
  27. "Quantitative phosphoproteomics reveals widespread full phosphorylation site occupancy during mitosis."Sci. Signal. 3:RA3-RA3(2010) [PubMed] [Europe PMC] [Abstract]
  28. "Initial characterization of the human central proteome."BMC Syst. Biol. 5:17-17(2011) [PubMed] [Europe PMC] [Abstract]
  29. "System-wide temporal characterization of the proteome and phosphoproteome of human embryonic stem cell differentiation."Sci. Signal. 4:RS3-RS3(2011) [PubMed] [Europe PMC] [Abstract]
  30. "Comparative large-scale characterisation of plant vs. mammal proteins reveals similar and idiosyncratic N-alpha acetylation features."Mol. Cell. Proteomics 11:M111.015131-M111.015131(2012) [PubMed] [Europe PMC] [Abstract]
  31. "An enzyme assisted RP-RPLC approach for in-depth analysis of human liver phosphoproteome."J. Proteomics 96:253-262(2014) [PubMed] [Europe PMC] [Abstract]
  32. "Crystal structure of human spliceosomal U1 snRNP at 5.5 A resolution."Nature 458:475-480(2009) [PubMed] [Europe PMC] [Abstract]