≡

SNAP Associated Protein (SNAPAP)

[Edit]

SNAPIN; SNAP-25-Binding Protein; Biogenesis of lysosome-related organelles complex 1 subunit 7; Synaptosomal-associated protein 25-binding protein

SNAP Associated Protein (SNAPAP)
CCC H163
HGNC 17145
MGI 1333745
PubMed 17088214
UniProt O95295
Wiki SNAPAP
SNAPAP is a component of the SNARE complex of proteins that is required for synaptic vesicle docking and fusion. SNAPAP is also a component of the ubiquitously expressed BLOC1 multisubunit protein complex. The deduced 136-amino acid protein has a calculated molecular mass of 15 kD. It contains an N-terminal hydrophobic segment characteristic of a transmembrane domain and a coiled-coil C-terminal region. SNAPAP shares 98% sequence identity with the mouse homolog. Western blot analysis of various rat tissues showed SNAPAP almost exclusively in brain and synaptosome preparations. Further analysis indicated SNAPAP in all 12 rat brain areas examined; fractionation of rat cerebral synaptosomes indicated that SNAPAP partitions with the synaptic vesicle fraction and not with cytosolic or plasma membrane fractions.

Organism species: Homo sapiens (Human)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins RPH163Hu01 Recombinant SNAP Associated Protein (SNAPAP) Positive Control; Immunogen; SDS-PAGE; WB.
Antibodies MAH163Hu21 Monoclonal Antibody to SNAP Associated Protein (SNAPAP) WB; IHC; ICC; IP.
PAH163Hu01 Polyclonal Antibody to SNAP Associated Protein (SNAPAP) WB; IHC; ICC; IP.
Assay Kits SEH163Hu ELISA Kit for SNAP Associated Protein (SNAPAP) Enzyme-linked immunosorbent assay for Antigen Detection.

Organism species: Mus musculus (Mouse)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins n/a Recombinant SNAP Associated Protein (SNAPAP) Recombinant Protein Customized Service Offer
Antibodies n/a Monoclonal Antibody to SNAP Associated Protein (SNAPAP) Monoclonal Antibody Customized Service Offer
n/a Polyclonal Antibody to SNAP Associated Protein (SNAPAP) Polyclonal Antibody Customized Service Offer
Assay Kits n/a CLIA Kit for SNAP Associated Protein (SNAPAP) CLIA Kit Customized Service Offer
n/a ELISA Kit for SNAP Associated Protein (SNAPAP) ELISA Kit Customized Service Offer
  1. "Snapin: a SNARE-associated protein implicated in synaptic transmission."Nat. Neurosci. 2:119-124(1999) [PubMed] [Europe PMC] [Abstract]
  2. "Complete sequencing and characterization of 21,243 full-length human cDNAs." Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract]
  3. "The DNA sequence and biological annotation of human chromosome 1." Nature 441:315-321(2006) [PubMed] [Europe PMC] [Abstract]
  4. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
  5. "Snapin interacts with the N-terminus of regulator of G protein signaling 7."Biochem. Biophys. Res. Commun. 303:594-599(2003) [PubMed] [Europe PMC] [Abstract]
  6. "Identification of snapin and three novel proteins (BLOS1, BLOS2, and BLOS3/reduced pigmentation) as subunits of biogenesis of lysosome-related organelles complex-1 (BLOC-1)."J. Biol. Chem. 279:28393-28401(2004) [PubMed] [Europe PMC] [Abstract]
  7. "Centriolin anchoring of exocyst and SNARE complexes at the midbody is required for secretory-vesicle-mediated abscission."Cell 123:75-87(2005) [PubMed] [Europe PMC] [Abstract]
  8. "BLOC-1 is required for cargo-specific sorting from vacuolar early endosomes toward lysosome-related organelles."Mol. Biol. Cell 18:768-780(2007) [PubMed] [Europe PMC] [Abstract]
  9. "The dystonia-associated protein torsinA modulates synaptic vesicle recycling."J. Biol. Chem. 283:7568-7579(2008) [PubMed] [Europe PMC] [Abstract]
  10. "A quantitative atlas of mitotic phosphorylation."Proc. Natl. Acad. Sci. U.S.A. 105:10762-10767(2008) [PubMed] [Europe PMC] [Abstract]
  11. "Lys-N and trypsin cover complementary parts of the phosphoproteome in a refined SCX-based approach."Anal. Chem. 81:4493-4501(2009) [PubMed] [Europe PMC] [Abstract]
  12. "The SNARE-associated component SNAPIN binds PUMILIO2 and NANOS1 proteins in human male germ cells."Mol. Hum. Reprod. 15:173-179(2009) [PubMed] [Europe PMC] [Abstract]
  13. "Quantitative phosphoproteomic analysis of T cell receptor signaling reveals system-wide modulation of protein-protein interactions."Sci. Signal. 2:RA46-RA46(2009) [PubMed] [Europe PMC] [Abstract]
  14. "Quantitative phosphoproteomics reveals widespread full phosphorylation site occupancy during mitosis."Sci. Signal. 3:RA3-RA3(2010) [PubMed] [Europe PMC] [Abstract]
  15. "Initial characterization of the human central proteome."BMC Syst. Biol. 5:17-17(2011) [PubMed] [Europe PMC] [Abstract]
  16. "CSN complex controls the stability of selected synaptic proteins via a torsinA-dependent process."EMBO J. 30:181-193(2011) [PubMed] [Europe PMC] [Abstract]
  17. "Human cytomegalovirus primase UL70 specifically interacts with cellular factor Snapin."J. Virol. 85:11732-11741(2011) [PubMed] [Europe PMC] [Abstract]
  18. "Assembly and architecture of biogenesis of lysosome-related organelles complex-1 (BLOC-1)."J. Biol. Chem. 287:5882-5890(2012) [PubMed] [Europe PMC] [Abstract]
  19. "N-terminal acetylome analyses and functional insights of the N-terminal acetyltransferase NatB."Proc. Natl. Acad. Sci. U.S.A. 109:12449-12454(2012) [PubMed] [Europe PMC] [Abstract]