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SH3 Domain Binding Protein 2 (SH3BP2)

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CRBM; RES4-23; Cherubism

SH3 Domain Binding Protein 2 (SH3BP2)
CCC H176
HGNC 10825
MGI 1346349
PubMed 22640988
RGD 1310588
UniProt P78314
Wiki SH3BP2
SH3BP2 has an N-terminal pleckstrin homology (PH) domain, an SH3-binding proline-rich region, and a C-terminal SH2 domain. The protein binds to the SH3 domains of several proteins including the ABL1 and SYK protein tyrosine kinases , and functions as a cytoplasmic adaptor protein to positively regulate transcriptional activity in T, natural killer (NK), and basophilic cells. Mutations in this gene result in cherubism. Multiple transcript variants encoding different isoforms have been found for this gene.
The deduced 561-residue protein contains an Src homology 2 (SH2) domain, an Src homology 3 (SH3)-binding domain, and a pleckstrin homology domain, suggesting a possible role in signal transduction.

Organism species: Homo sapiens (Human)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins RPH176Hu01 Recombinant SH3 Domain Binding Protein 2 (SH3BP2) Positive Control; Immunogen; SDS-PAGE; WB.
Antibodies MAH176Hu21 Monoclonal Antibody to SH3 Domain Binding Protein 2 (SH3BP2) WB; IHC; ICC; IP.
PAH176Hu01 Polyclonal Antibody to SH3 Domain Binding Protein 2 (SH3BP2) WB; IHC; ICC; IP.
Assay Kits SEH176Hu ELISA Kit for SH3 Domain Binding Protein 2 (SH3BP2) Enzyme-linked immunosorbent assay for Antigen Detection.

Organism species: Mus musculus (Mouse)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins n/a Recombinant SH3 Domain Binding Protein 2 (SH3BP2) Recombinant Protein Customized Service Offer
Antibodies n/a Monoclonal Antibody to SH3 Domain Binding Protein 2 (SH3BP2) Monoclonal Antibody Customized Service Offer
n/a Polyclonal Antibody to SH3 Domain Binding Protein 2 (SH3BP2) Polyclonal Antibody Customized Service Offer
Assay Kits n/a CLIA Kit for SH3 Domain Binding Protein 2 (SH3BP2) CLIA Kit Customized Service Offer
n/a ELISA Kit for SH3 Domain Binding Protein 2 (SH3BP2) ELISA Kit Customized Service Offer

Organism species: Rattus norvegicus (Rat)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins n/a Recombinant SH3 Domain Binding Protein 2 (SH3BP2) Recombinant Protein Customized Service Offer
Antibodies n/a Monoclonal Antibody to SH3 Domain Binding Protein 2 (SH3BP2) Monoclonal Antibody Customized Service Offer
n/a Polyclonal Antibody to SH3 Domain Binding Protein 2 (SH3BP2) Polyclonal Antibody Customized Service Offer
Assay Kits n/a CLIA Kit for SH3 Domain Binding Protein 2 (SH3BP2) CLIA Kit Customized Service Offer
n/a ELISA Kit for SH3 Domain Binding Protein 2 (SH3BP2) ELISA Kit Customized Service Offer
  1. "3BP2 binds to phosphatidylinositols; linking the hemopoietic tyrosine kinase c-FES to the cytoplasmic membrane in a phosphorylation dependent mechanism."Blood 88:473A-473A(1996)
  2. "Identification and characterization of the human homologue of SH3BP2, an SH3 binding domain protein within a common region of deletion at 4p16.3 involved in bladder cancer."Genomics 44:163-170(1997) [PubMed] [Europe PMC] [Abstract]
  3. "The primary structure and genomic organization of five novel transcripts located close to the Huntington's disease gene on human chromosome 4p16.3."DNA Res. 5:177-186(1998) [PubMed] [Europe PMC] [Abstract]
  4. "Complete sequencing and characterization of 21,243 full-length human cDNAs." Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract]
  5. "Generation and annotation of the DNA sequences of human chromosomes 2 and 4." Nature 434:724-731(2005) [PubMed] [Europe PMC] [Abstract]
  6. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
  7. "An unappreciated role for RNA surveillance."Genome Biol. 5:R8.1-R8.16(2004) [PubMed] [Europe PMC] [Abstract]
  8. "A quantitative atlas of mitotic phosphorylation."Proc. Natl. Acad. Sci. U.S.A. 105:10762-10767(2008) [PubMed] [Europe PMC] [Abstract]
  9. "An enzyme assisted RP-RPLC approach for in-depth analysis of human liver phosphoproteome."J. Proteomics 96:253-262(2014) [PubMed] [Europe PMC] [Abstract]
  10. "Solution structure of the SH2 domain of human SH3BP2 protein."Submitted (NOV-2005) to the PDB data bank
  11. "Mutations in the gene encoding c-Abl-binding protein SH3BP2 cause cherubism."Nat. Genet. 28:125-126(2001) [PubMed] [Europe PMC] [Abstract]
  12. "Novel mutation in the gene encoding c-Abl-binding protein SH3BP2 causes cherubism."Am. J. Med. Genet. A 121:37-40(2003) [PubMed] [Europe PMC] [Abstract]
  13. "A missense mutation in the SH3BP2 gene on chromosome 4p16.3 found in a case of nonfamilial cherubism."Cleft Palate Craniofac. J. 40:632-638(2003) [PubMed] [Europe PMC] [Abstract]