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Scavenger Receptor Class B Member 2 (SCARB2)

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CD36L2; LIMP2; LIMPII; 85 kDa lysosomal membrane sialoglycoprotein; Collagen Type I Receptor,Thrombospondin Receptor-Like 2; Lysosomal Integral Membrane Protein II

Scavenger Receptor Class B Member 2 (SCARB2)
CCC H192
HGNC 1665
MGI 1196458
PubMed 22272359
RGD 621882
UniProt Q14108
Wiki SCARB2
SCARB2 is a type III glycoprotein that is located primarily in limiting membranes of lysosomes and endosomes. Studies of the similar protein in mice and rat suggested that this protein may participate in membrane transportation and the reorganization of endosomal/lysosomal compartment. Deficiency of the similar protein in mice was reported to impair cell membrane transport processes and cause pelvic junction obstruction, deafness, and peripheral neuropathy. The open reading frame predicted an amino acid sequence of 478 amino acids, 85% identical to that of rat LIMPII and 100% identical to that of the human glycoprotein LGP85 sequence published by Fujita et al. (1992). Northern blot analysis revealed that CD36L2 is expressed as transcripts of 2.2 and 4.5 kb in a variety of human cell lines.

Organism species: Homo sapiens (Human)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins n/a Recombinant Scavenger Receptor Class B Member 2 (SCARB2) Recombinant Protein Customized Service Offer
Antibodies n/a Monoclonal Antibody to Scavenger Receptor Class B Member 2 (SCARB2) Monoclonal Antibody Customized Service Offer
n/a Polyclonal Antibody to Scavenger Receptor Class B Member 2 (SCARB2) Polyclonal Antibody Customized Service Offer
Assay Kits n/a CLIA Kit for Scavenger Receptor Class B Member 2 (SCARB2) CLIA Kit Customized Service Offer
n/a ELISA Kit for Scavenger Receptor Class B Member 2 (SCARB2) ELISA Kit Customized Service Offer

Organism species: Mus musculus (Mouse)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins n/a Recombinant Scavenger Receptor Class B Member 2 (SCARB2) Recombinant Protein Customized Service Offer
Antibodies n/a Monoclonal Antibody to Scavenger Receptor Class B Member 2 (SCARB2) Monoclonal Antibody Customized Service Offer
n/a Polyclonal Antibody to Scavenger Receptor Class B Member 2 (SCARB2) Polyclonal Antibody Customized Service Offer
Assay Kits n/a CLIA Kit for Scavenger Receptor Class B Member 2 (SCARB2) CLIA Kit Customized Service Offer
n/a ELISA Kit for Scavenger Receptor Class B Member 2 (SCARB2) ELISA Kit Customized Service Offer

Organism species: Rattus norvegicus (Rat)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins n/a Recombinant Scavenger Receptor Class B Member 2 (SCARB2) Recombinant Protein Customized Service Offer
Antibodies n/a Monoclonal Antibody to Scavenger Receptor Class B Member 2 (SCARB2) Monoclonal Antibody Customized Service Offer
n/a Polyclonal Antibody to Scavenger Receptor Class B Member 2 (SCARB2) Polyclonal Antibody Customized Service Offer
Assay Kits n/a CLIA Kit for Scavenger Receptor Class B Member 2 (SCARB2) CLIA Kit Customized Service Offer
n/a ELISA Kit for Scavenger Receptor Class B Member 2 (SCARB2) ELISA Kit Customized Service Offer
  1. "Isolation and sequencing of a cDNA clone encoding the 85 kDa human lysosomal sialoglycoprotein (hLGP85) in human metastatic pancreas islet tumor cells."Biochem. Biophys. Res. Commun. 184:604-611(1992) [PubMed] [Europe PMC] [Abstract]
  2. "The CD36, CLA-1 (CD36L1), and LIMPII (CD36L2) gene family: cellular distribution, chromosomal location, and genetic evolution."Genomics 25:100-106(1995) [PubMed] [Europe PMC] [Abstract]
  3. "Complete sequencing and characterization of 21,243 full-length human cDNAs." Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract]
  4. "Generation and annotation of the DNA sequences of human chromosomes 2 and 4." Nature 434:724-731(2005) [PubMed] [Europe PMC] [Abstract]
  5. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
  6. "The residues Leu(Ile)475-Ile(Leu, Val, Ala)476, contained in the extended carboxyl cytoplasmic tail, are critical for targeting of the resident lysosomal membrane protein LIMP II to lysosomes."J. Biol. Chem. 269:6622-6631(1994) [PubMed] [Europe PMC] [Abstract]
  7. "Cluster analysis of an extensive human breast cancer cell line protein expression map database."Proteomics 2:212-223(2002) [PubMed] [Europe PMC] [Abstract]
  8. "Identification and quantification of N-linked glycoproteins using hydrazide chemistry, stable isotope labeling and mass spectrometry."Nat. Biotechnol. 21:660-666(2003) [PubMed] [Europe PMC] [Abstract]
  9. "LIMP-2 is a receptor for lysosomal mannose-6-phosphate-independent targeting of beta-glucocerebrosidase."Cell 131:770-783(2007) [PubMed] [Europe PMC] [Abstract]
  10. "Integral and associated lysosomal membrane proteins."Traffic 8:1676-1686(2007) [PubMed] [Europe PMC] [Abstract]
  11. "Array-based gene discovery with three unrelated subjects shows SCARB2/LIMP-2 deficiency causes myoclonus epilepsy and glomerulosclerosis." Am. J. Hum. Genet. 82:673-684(2008) [PubMed] [Europe PMC] [Abstract]
  12. "A nonsense mutation in the LIMP-2 gene associated with progressive myoclonic epilepsy and nephrotic syndrome."Hum. Mol. Genet. 17:2238-2243(2008) [PubMed] [Europe PMC] [Abstract]
  13. "Glycoproteomics analysis of human liver tissue by combination of multiple enzyme digestion and hydrazide chemistry."J. Proteome Res. 8:651-661(2009) [PubMed] [Europe PMC] [Abstract]
  14. "Mutation of SCARB2 in a patient with progressive myoclonus epilepsy and demyelinating peripheral neuropathy."Arch. Neurol. 68:812-813(2011) [PubMed] [Europe PMC] [Abstract]
  15. "Initial characterization of the human central proteome."BMC Syst. Biol. 5:17-17(2011) [PubMed] [Europe PMC] [Abstract]
  16. "A mutation in SCARB2 is a modifier in Gaucher disease."Hum. Mutat. 32:1232-1238(2011) [PubMed] [Europe PMC] [Abstract]
  17. "An enzyme assisted RP-RPLC approach for in-depth analysis of human liver phosphoproteome."J. Proteomics 96:253-262(2014) [PubMed] [Europe PMC] [Abstract]
  18. "Structure of LIMP-2 provides functional insights with implications for SR-BI and CD36."Nature 504:172-176(2013) [PubMed] [Europe PMC] [Abstract]
  19. "Biochemical and molecular findings in a patient with myoclonic epilepsy due to a mistarget of the beta-glucosidase enzyme."Mol. Genet. Metab. 97:309-311(2009) [PubMed] [Europe PMC] [Abstract]