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Ras Responsive Element Binding Protein 1 (RREB1)

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FINB; LZ321; RREB-1; Zep-1; HNT; Hindsight Homolog; Finger protein in nuclear bodies; Raf-responsive zinc finger protein LZ321; Zinc finger motif enhancer-binding protein 1

Ras Responsive Element Binding Protein 1 (RREB1)
CCC H209
HGNC 10449
MGI 2443664
PubMed 21792086
RGD 1310904
UniProt Q92766
Wiki RREB1
RREB1 is a zinc finger transcription factor that binds to RAS-responsive elements (RREs) of gene promoters. It has been shown that the calcitonin gene promoter contains an RRE and that the encoded protein binds there and increases expression of calcitonin, which may be involved in Ras/Raf-mediated cell differentiation. Multiple transcript variants encoding several different isoforms have been found for this gene.
RREB1, a zinc finger transcription factor, was shown to bind specifically to the distal RAS-responsive element (RRE) in the calcitonin gene promoter and to augment the RAS/RAF-mediated transcriptional response of that promoter. Thus, they concluded that it may be involved in RAS/RAF-mediated cell differentiation.

Organism species: Homo sapiens (Human)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins n/a Recombinant Ras Responsive Element Binding Protein 1 (RREB1) Recombinant Protein Customized Service Offer
Antibodies n/a Monoclonal Antibody to Ras Responsive Element Binding Protein 1 (RREB1) Monoclonal Antibody Customized Service Offer
n/a Polyclonal Antibody to Ras Responsive Element Binding Protein 1 (RREB1) Polyclonal Antibody Customized Service Offer
Assay Kits n/a CLIA Kit for Ras Responsive Element Binding Protein 1 (RREB1) CLIA Kit Customized Service Offer
n/a ELISA Kit for Ras Responsive Element Binding Protein 1 (RREB1) ELISA Kit Customized Service Offer

Organism species: Mus musculus (Mouse)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins n/a Recombinant Ras Responsive Element Binding Protein 1 (RREB1) Recombinant Protein Customized Service Offer
Antibodies n/a Monoclonal Antibody to Ras Responsive Element Binding Protein 1 (RREB1) Monoclonal Antibody Customized Service Offer
n/a Polyclonal Antibody to Ras Responsive Element Binding Protein 1 (RREB1) Polyclonal Antibody Customized Service Offer
Assay Kits n/a CLIA Kit for Ras Responsive Element Binding Protein 1 (RREB1) CLIA Kit Customized Service Offer
n/a ELISA Kit for Ras Responsive Element Binding Protein 1 (RREB1) ELISA Kit Customized Service Offer

Organism species: Rattus norvegicus (Rat)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins n/a Recombinant Ras Responsive Element Binding Protein 1 (RREB1) Recombinant Protein Customized Service Offer
Antibodies n/a Monoclonal Antibody to Ras Responsive Element Binding Protein 1 (RREB1) Monoclonal Antibody Customized Service Offer
n/a Polyclonal Antibody to Ras Responsive Element Binding Protein 1 (RREB1) Polyclonal Antibody Customized Service Offer
Assay Kits n/a CLIA Kit for Ras Responsive Element Binding Protein 1 (RREB1) CLIA Kit Customized Service Offer
n/a ELISA Kit for Ras Responsive Element Binding Protein 1 (RREB1) ELISA Kit Customized Service Offer
  1. "A novel zinc finger protein, Finb, is a transcriptional activator and localized in nuclear bodies."Gene 195:267-275(1997) [PubMed] [Europe PMC] [Abstract]
  2. "Finb, a multiple zinc finger protein, represses transcription of the human angiotensinogen gene."Int. J. Mol. Med. 13:637-642(2004) [PubMed] [Europe PMC] [Abstract]
  3. "RREB1 transcription factor splice variants in urologic cancer."Am. J. Pathol. 179:477-486(2011) [PubMed] [Europe PMC] [Abstract]
  4. "The DNA sequence and analysis of human chromosome 6." Nature 425:805-811(2003) [PubMed] [Europe PMC] [Abstract]
  5. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
  6. "RREB-1, a novel zinc finger protein, is involved in the differentiation response to Ras in human medullary thyroid carcinomas."Mol. Cell. Biol. 16:5335-5345(1996) [PubMed] [Europe PMC] [Abstract]
  7. "A human Raf-responsive zinc-finger protein that binds to divergent sequences."Nucleic Acids Res. 27:2947-2956(1999) [PubMed] [Europe PMC] [Abstract]
  8. "Novel transcriptional potentiation of BETA2/NeuroD on the secretin gene promoter by the DNA-binding protein Finb/RREB-1."Mol. Cell. Biol. 23:259-271(2003) [PubMed] [Europe PMC] [Abstract]
  9. "The zinc finger protein Ras-responsive element binding protein-1 is a coregulator of the androgen receptor: implications for the role of the Ras pathway in enhancing androgenic signaling in prostate cancer."Mol. Endocrinol. 21:2056-2070(2007) [PubMed] [Europe PMC] [Abstract]
  10. "A quantitative atlas of mitotic phosphorylation."Proc. Natl. Acad. Sci. U.S.A. 105:10762-10767(2008) [PubMed] [Europe PMC] [Abstract]
  11. "Lys-N and trypsin cover complementary parts of the phosphoproteome in a refined SCX-based approach."Anal. Chem. 81:4493-4501(2009) [PubMed] [Europe PMC] [Abstract]
  12. "Quantitative phosphoproteomic analysis of T cell receptor signaling reveals system-wide modulation of protein-protein interactions."Sci. Signal. 2:RA46-RA46(2009) [PubMed] [Europe PMC] [Abstract]
  13. "Quantitative phosphoproteomics reveals widespread full phosphorylation site occupancy during mitosis."Sci. Signal. 3:RA3-RA3(2010) [PubMed] [Europe PMC] [Abstract]
  14. "System-wide temporal characterization of the proteome and phosphoproteome of human embryonic stem cell differentiation."Sci. Signal. 4:RS3-RS3(2011) [PubMed] [Europe PMC] [Abstract]
  15. "An enzyme assisted RP-RPLC approach for in-depth analysis of human liver phosphoproteome."J. Proteomics 96:253-262(2014) [PubMed] [Europe PMC] [Abstract]