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Regulating Synaptic Membrane Exocytosis 2 (RIMS2)

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OBOE; RAB3IP3; RIM2; Rab-3-interacting molecule 2

Regulating Synaptic Membrane Exocytosis 2 (RIMS2)
CCC H222
HGNC 17283
MGI 2152972
PubMed 9872452
RGD 620001
UniProt Q9UQ26
Wiki RIMS2
RIMS2 gene contains 32 exons and spans 747.9 kb. In addition to the 5-prime promoter region, RIMS2 has 2 internal promoters within GC-rich regions that are used for expression of RIM2-beta and RIM2-gamma.The deduced 1,188-amino acid protein was predicted to be related to RIM1 and to be involved in cell signaling/communication. RT-PCR analysis detected high expression of KIAA0751 in brain, with lower expression in ovary and testis.
rat Rim2 interacted with Rab3a and Rab3c in a GTP-dependent manner. Yeast 2-hybrid analysis of a rat brain cDNA library revealed that the C-terminal half of rat Rim2 interacted with Rimbp1 (BZRAP1) and Rimbp2 .

Organism species: Homo sapiens (Human)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins n/a Recombinant Regulating Synaptic Membrane Exocytosis 2 (RIMS2) Recombinant Protein Customized Service Offer
Antibodies n/a Monoclonal Antibody to Regulating Synaptic Membrane Exocytosis 2 (RIMS2) Monoclonal Antibody Customized Service Offer
n/a Polyclonal Antibody to Regulating Synaptic Membrane Exocytosis 2 (RIMS2) Polyclonal Antibody Customized Service Offer
Assay Kits n/a CLIA Kit for Regulating Synaptic Membrane Exocytosis 2 (RIMS2) CLIA Kit Customized Service Offer
n/a ELISA Kit for Regulating Synaptic Membrane Exocytosis 2 (RIMS2) ELISA Kit Customized Service Offer

Organism species: Mus musculus (Mouse)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins RPH222Mu01 Recombinant Regulating Synaptic Membrane Exocytosis 2 (RIMS2) Positive Control; Immunogen; SDS-PAGE; WB.
Antibodies PAH222Mu01 Polyclonal Antibody to Regulating Synaptic Membrane Exocytosis 2 (RIMS2) WB; IHC; ICC; IP.
Assay Kits n/a CLIA Kit for Regulating Synaptic Membrane Exocytosis 2 (RIMS2) CLIA Kit Customized Service Offer
n/a ELISA Kit for Regulating Synaptic Membrane Exocytosis 2 (RIMS2) ELISA Kit Customized Service Offer

Organism species: Rattus norvegicus (Rat)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins n/a Recombinant Regulating Synaptic Membrane Exocytosis 2 (RIMS2) Recombinant Protein Customized Service Offer
Antibodies n/a Monoclonal Antibody to Regulating Synaptic Membrane Exocytosis 2 (RIMS2) Monoclonal Antibody Customized Service Offer
n/a Polyclonal Antibody to Regulating Synaptic Membrane Exocytosis 2 (RIMS2) Polyclonal Antibody Customized Service Offer
Assay Kits n/a CLIA Kit for Regulating Synaptic Membrane Exocytosis 2 (RIMS2) CLIA Kit Customized Service Offer
n/a ELISA Kit for Regulating Synaptic Membrane Exocytosis 2 (RIMS2) ELISA Kit Customized Service Offer
  1. "Prediction of the coding sequences of unidentified human genes. XI. The complete sequences of 100 new cDNA clones from brain which code for large proteins in vitro."DNA Res. 5:277-286(1998) [PubMed] [Europe PMC] [Abstract]
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  4. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
  5. "Genomic definition of RIM proteins: evolutionary amplification of a family of synaptic regulatory proteins."Genomics 81:126-137(2003) [PubMed] [Europe PMC] [Abstract]
  6. "Quantitative phosphoproteomic analysis of T cell receptor signaling reveals system-wide modulation of protein-protein interactions."Sci. Signal. 2:RA46-RA46(2009) [PubMed] [Europe PMC] [Abstract]
  7. "System-wide temporal characterization of the proteome and phosphoproteome of human embryonic stem cell differentiation."Sci. Signal. 4:RS3-RS3(2011) [PubMed] [Europe PMC] [Abstract]
  8. "PDZ domain and the first C2 domain of human RIM2B."Submitted (NOV-2004) to the PDB data bank