≡

RAB Interacting Lysosomal Protein (RILP)

[Edit]

RAB Interacting Lysosomal Protein (RILP)
CCC H224
HGNC 30266
MGI 2144271
PubMed 11179213
RGD 1307691
UniProt Q96NA2
Wiki RILP
RILP is expressed at varying levels in all tissues examined. Expression was highest in adult heart, stomach, adrenal gland, thyroid gland, salivary gland, liver, and lung, and in fetal heart and liver. Expression was lowest in whole fetal brain and in all adult brain regions. Northern blot analysis confirmed ubiquitous expression of 0.9- and 1.8-kb transcripts. Expression levels of the 2 transcripts varied between tissues.The deduced 401-amino acid protein has a calculated molecular mass of about 45 kD and contains 2 coiled-coil regions. RILP shares significant homology with a mouse protein belonging to the ezrin-radixin-moesin (ERM) family. Northern blot analysis detected transcripts of about 1.2 and 1.8 kb in the 3 tissues tested (lung, spleen, and stomach). Western blot analysis detected a 50-kD RILP protein in all cell lines examined.

Organism species: Homo sapiens (Human)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins n/a Recombinant RAB Interacting Lysosomal Protein (RILP) Recombinant Protein Customized Service Offer
Antibodies n/a Monoclonal Antibody to RAB Interacting Lysosomal Protein (RILP) Monoclonal Antibody Customized Service Offer
n/a Polyclonal Antibody to RAB Interacting Lysosomal Protein (RILP) Polyclonal Antibody Customized Service Offer
Assay Kits n/a CLIA Kit for RAB Interacting Lysosomal Protein (RILP) CLIA Kit Customized Service Offer
n/a ELISA Kit for RAB Interacting Lysosomal Protein (RILP) ELISA Kit Customized Service Offer

Organism species: Mus musculus (Mouse)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins n/a Recombinant RAB Interacting Lysosomal Protein (RILP) Recombinant Protein Customized Service Offer
Antibodies n/a Monoclonal Antibody to RAB Interacting Lysosomal Protein (RILP) Monoclonal Antibody Customized Service Offer
n/a Polyclonal Antibody to RAB Interacting Lysosomal Protein (RILP) Polyclonal Antibody Customized Service Offer
Assay Kits n/a CLIA Kit for RAB Interacting Lysosomal Protein (RILP) CLIA Kit Customized Service Offer
n/a ELISA Kit for RAB Interacting Lysosomal Protein (RILP) ELISA Kit Customized Service Offer

Organism species: Rattus norvegicus (Rat)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins n/a Recombinant RAB Interacting Lysosomal Protein (RILP) Recombinant Protein Customized Service Offer
Antibodies n/a Monoclonal Antibody to RAB Interacting Lysosomal Protein (RILP) Monoclonal Antibody Customized Service Offer
n/a Polyclonal Antibody to RAB Interacting Lysosomal Protein (RILP) Polyclonal Antibody Customized Service Offer
Assay Kits n/a CLIA Kit for RAB Interacting Lysosomal Protein (RILP) CLIA Kit Customized Service Offer
n/a ELISA Kit for RAB Interacting Lysosomal Protein (RILP) ELISA Kit Customized Service Offer
  1. "Rab-interacting lysosomal protein (RILP): the Rab7 effector required for transport to lysosomes."EMBO J. 20:683-693(2001) [PubMed] [Europe PMC] [Abstract]
  2. "Complete sequencing and characterization of 21,243 full-length human cDNAs." Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract]
  3. "Large-scale cDNA transfection screening for genes related to cancer development and progression." Proc. Natl. Acad. Sci. U.S.A. 101:15724-15729(2004) [PubMed] [Europe PMC] [Abstract]
  4. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
  5. "Expression analysis and chromosomal assignment of PRA1 and RILP genes."Biochem. Biophys. Res. Commun. 286:815-819(2001) [PubMed] [Europe PMC] [Abstract]
  6. "The Rab7 effector protein RILP controls lysosomal transport by inducing the recruitment of dynein-dynactin motors."Curr. Biol. 11:1680-1685(2001) [PubMed] [Europe PMC] [Abstract]
  7. "Interorganellar regulation of lysosome positioning by the Golgi apparatus through Rab34 interaction with Rab-interacting lysosomal protein."Mol. Biol. Cell 13:4317-4332(2002) [PubMed] [Europe PMC] [Abstract]
  8. "Phagosomes fuse with late endosomes and/or lysosomes by extension of membrane protrusions along microtubules: role of Rab7 and RILP."Mol. Cell. Biol. 23:6494-6506(2003) [PubMed] [Europe PMC] [Abstract]
  9. "A unique region of RILP distinguishes it from its related proteins in its regulation of lysosomal morphology and interaction with Rab7 and Rab34."Mol. Biol. Cell 15:815-826(2004) [PubMed] [Europe PMC] [Abstract]
  10. "The Rab-interacting lysosomal protein, a Rab7 and Rab34 effector, is capable of self-interaction."Biochem. Biophys. Res. Commun. 334:128-133(2005) [PubMed] [Europe PMC] [Abstract]
  11. "A quantitative atlas of mitotic phosphorylation."Proc. Natl. Acad. Sci. U.S.A. 105:10762-10767(2008) [PubMed] [Europe PMC] [Abstract]
  12. "Neuronal ceroid lipofuscinosis protein CLN3 interacts with motor proteins and modifies location of late endosomal compartments."Cell. Mol. Life Sci. 69:2075-2089(2012) [PubMed] [Europe PMC] [Abstract]
  13. "An enzyme assisted RP-RPLC approach for in-depth analysis of human liver phosphoproteome."J. Proteomics 96:253-262(2014) [PubMed] [Europe PMC] [Abstract]
  14. "Structural basis for recruitment of RILP by small GTPase Rab7."EMBO J. 24:1491-1501(2005) [PubMed] [Europe PMC] [Abstract]