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Regulatory Factor X 1 (RFX1)

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EF-C; Trans-Acting Regulatory Factor 1; Enhancer Factor C; MHC Class II Regulatory Factor RFX

Regulatory Factor X 1 (RFX1)
CCC H232
HGNC 9982
MGI 105982
PubMed 8289803
RGD 1306574
UniProt P22670
Wiki RFX1
RFX1 is a member of the regulatory factor X gene family, which encodes transcription factors that contain a highly-conserved winged helix DNA binding domain.
The protein encoded by this gene is structurally related to regulatory factors X2, X3, X4, and X5. It is a transcriptional activator that can bind DNA as a monomer or as a heterodimer with RFX family members X2, X3, and X5, but not with X4. This protein binds to the X-boxes of MHC class II genes and is essential for their expression. Also, it can bind to an inverted repeat that is required for expression of hepatitis B virus genes.The RFX1 gene product is a transactivator of the human hepatitis B viral enhancer I.RFX1 is close to another DNA-binding factor, LYL1

Organism species: Homo sapiens (Human)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins n/a Recombinant Regulatory Factor X 1 (RFX1) Recombinant Protein Customized Service Offer
Antibodies n/a Monoclonal Antibody to Regulatory Factor X 1 (RFX1) Monoclonal Antibody Customized Service Offer
n/a Polyclonal Antibody to Regulatory Factor X 1 (RFX1) Polyclonal Antibody Customized Service Offer
Assay Kits n/a CLIA Kit for Regulatory Factor X 1 (RFX1) CLIA Kit Customized Service Offer
n/a ELISA Kit for Regulatory Factor X 1 (RFX1) ELISA Kit Customized Service Offer

Organism species: Mus musculus (Mouse)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins n/a Recombinant Regulatory Factor X 1 (RFX1) Recombinant Protein Customized Service Offer
Antibodies n/a Monoclonal Antibody to Regulatory Factor X 1 (RFX1) Monoclonal Antibody Customized Service Offer
n/a Polyclonal Antibody to Regulatory Factor X 1 (RFX1) Polyclonal Antibody Customized Service Offer
Assay Kits n/a CLIA Kit for Regulatory Factor X 1 (RFX1) CLIA Kit Customized Service Offer
n/a ELISA Kit for Regulatory Factor X 1 (RFX1) ELISA Kit Customized Service Offer

Organism species: Rattus norvegicus (Rat)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins n/a Recombinant Regulatory Factor X 1 (RFX1) Recombinant Protein Customized Service Offer
Antibodies n/a Monoclonal Antibody to Regulatory Factor X 1 (RFX1) Monoclonal Antibody Customized Service Offer
n/a Polyclonal Antibody to Regulatory Factor X 1 (RFX1) Polyclonal Antibody Customized Service Offer
Assay Kits n/a CLIA Kit for Regulatory Factor X 1 (RFX1) CLIA Kit Customized Service Offer
n/a ELISA Kit for Regulatory Factor X 1 (RFX1) ELISA Kit Customized Service Offer
  1. "MHC class II regulatory factor RFX has a novel DNA-binding domain and a functionally independent dimerization domain."Genes Dev. 4:1528-1540(1990) [PubMed] [Europe PMC] [Abstract]
  2. "The DNA sequence and biology of human chromosome 19." Nature 428:529-535(2004) [PubMed] [Europe PMC] [Abstract]
  3. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
  4. "RFX1 is identical to enhancer factor C and functions as a transactivator of the hepatitis B virus enhancer."Mol. Cell. Biol. 13:6375-6384(1993) [PubMed] [Europe PMC] [Abstract]
  5. "Transcription factor RFX1 helps control the promoter of the mouse ribosomal protein-encoding gene rpL30 by binding to its alpha element."Gene 132:279-283(1993) [PubMed] [Europe PMC] [Abstract]
  6. "The DNA-binding defect observed in major histocompatibility complex class II regulatory mutants concerns only one member of a family of complexes binding to the X boxes of class II promoters."Mol. Cell. Biol. 12:4076-4083(1992) [PubMed] [Europe PMC] [Abstract]
  7. "Kinase-selective enrichment enables quantitative phosphoproteomics of the kinome across the cell cycle."Mol. Cell 31:438-448(2008) [PubMed] [Europe PMC] [Abstract]
  8. "A quantitative atlas of mitotic phosphorylation."Proc. Natl. Acad. Sci. U.S.A. 105:10762-10767(2008) [PubMed] [Europe PMC] [Abstract]
  9. "Quantitative phosphoproteomic analysis of T cell receptor signaling reveals system-wide modulation of protein-protein interactions."Sci. Signal. 2:RA46-RA46(2009) [PubMed] [Europe PMC] [Abstract]
  10. "Quantitative phosphoproteomics reveals widespread full phosphorylation site occupancy during mitosis."Sci. Signal. 3:RA3-RA3(2010) [PubMed] [Europe PMC] [Abstract]
  11. "Initial characterization of the human central proteome."BMC Syst. Biol. 5:17-17(2011) [PubMed] [Europe PMC] [Abstract]
  12. "Structure of the winged-helix protein hRFX1 reveals a new mode of DNA binding."Nature 403:916-921(2000) [PubMed] [Europe PMC] [Abstract]