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Riboflavin Kinase (RFK)

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RIFK; Flavokinase; ATP:riboflavin 5'-phosphotransferase

Riboflavin Kinase (RFK)
CCC H234
HGNC 30324
MGI 1914688
PubMed 19641494
RGD 1563242
UniProt Q969G6
Wiki RFK
Riboflavin kinase (RFK; EC 2.7.1.26) is an essential enzyme that catalyzes the phosphorylation of riboflavin (vitamin B2) to form flavin mononucleotide (FMN), an obligatory step in vitamin B2 utilization and flavin cofactor synthesis.
The reference genome sequence contains a polymorphism that changes the upstream ATG found in most transcripts to ATT; hence the next downstream AUG is annotated. This polymorphism is represented in the Reference SNP, rs2490582. The reference genome polymorphism results in a protein that is 7 aa shorter at the N-terminus, and is supported by homologous proteins. It is also possible that leaky scanning by ribosomes would permit translation initiation from the downstream AUG in alleles containing the upstream AUG.

Organism species: Homo sapiens (Human)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins RPH234Hu01 Recombinant Riboflavin Kinase (RFK) Positive Control; Immunogen; SDS-PAGE; WB.
Antibodies PAH234Hu01 Polyclonal Antibody to Riboflavin Kinase (RFK) WB; IHC; ICC; IP.
MAH234Hu21 Monoclonal Antibody to Riboflavin Kinase (RFK) WB; IHC; ICC; IP.
Assay Kits SEH234Hu ELISA Kit for Riboflavin Kinase (RFK) Enzyme-linked immunosorbent assay for Antigen Detection.

Organism species: Mus musculus (Mouse)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins n/a Recombinant Riboflavin Kinase (RFK) Recombinant Protein Customized Service Offer
Antibodies n/a Monoclonal Antibody to Riboflavin Kinase (RFK) Monoclonal Antibody Customized Service Offer
n/a Polyclonal Antibody to Riboflavin Kinase (RFK) Polyclonal Antibody Customized Service Offer
Assay Kits n/a CLIA Kit for Riboflavin Kinase (RFK) CLIA Kit Customized Service Offer
n/a ELISA Kit for Riboflavin Kinase (RFK) ELISA Kit Customized Service Offer

Organism species: Rattus norvegicus (Rat)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins n/a Recombinant Riboflavin Kinase (RFK) Recombinant Protein Customized Service Offer
Antibodies n/a Monoclonal Antibody to Riboflavin Kinase (RFK) Monoclonal Antibody Customized Service Offer
n/a Polyclonal Antibody to Riboflavin Kinase (RFK) Polyclonal Antibody Customized Service Offer
Assay Kits n/a CLIA Kit for Riboflavin Kinase (RFK) CLIA Kit Customized Service Offer
n/a ELISA Kit for Riboflavin Kinase (RFK) ELISA Kit Customized Service Offer
  1. "Complete sequencing and characterization of 21,243 full-length human cDNAs." Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract]
  2. "DNA sequence and analysis of human chromosome 9." Nature 429:369-374(2004) [PubMed] [Europe PMC] [Abstract]
  3. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
  4. "Riboflavin kinase couples TNF receptor 1 to NADPH oxidase."Nature 460:1159-1163(2009) [PubMed] [Europe PMC] [Abstract]
  5. "Initial characterization of the human central proteome."BMC Syst. Biol. 5:17-17(2011) [PubMed] [Europe PMC] [Abstract]
  6. "Crystal structure of human riboflavin kinase reveals a beta barrel fold and a novel active site arch."Structure 11:265-273(2003) [PubMed] [Europe PMC] [Abstract]