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Receptor Accessory Protein 1 (REEP1)

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SPG31; C2orf23; Receptor Expression Enhancing Protein 1

Receptor Accessory Protein 1 (REEP1)
CCC H237
HGNC 25786
MGI 1098827
PubMed 16271481
RGD 1305230
UniProt Q9H902
Wiki REEP1
Transport of G protein-coupled receptors (GPCRs) to the cell surface membrane is critical for receptor-ligand recognition. However, mammalian GPCR odorant receptors (ORs), when heterologously expressed in cells, are poorly expressed on the cell surface.
The deduced mouse Reep1 protein contains 201 amino acids. Reep1 has 2 transmembrane domains, the first of which may function as a signal peptide. Northern blot analysis of mouse tissues detected expression of Reep1 in olfactory and vomeronasal organs and in brain. In situ hybridization of mouse olfactory epithelium revealed specific expression of Reep1 in olfactory neurons. In situ hybridization of mouse brain detected Reep1 expression in a subset of brain cells.

Organism species: Homo sapiens (Human)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins n/a Recombinant Receptor Accessory Protein 1 (REEP1) Recombinant Protein Customized Service Offer
Antibodies n/a Monoclonal Antibody to Receptor Accessory Protein 1 (REEP1) Monoclonal Antibody Customized Service Offer
n/a Polyclonal Antibody to Receptor Accessory Protein 1 (REEP1) Polyclonal Antibody Customized Service Offer
Assay Kits n/a CLIA Kit for Receptor Accessory Protein 1 (REEP1) CLIA Kit Customized Service Offer
n/a ELISA Kit for Receptor Accessory Protein 1 (REEP1) ELISA Kit Customized Service Offer

Organism species: Mus musculus (Mouse)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins n/a Recombinant Receptor Accessory Protein 1 (REEP1) Recombinant Protein Customized Service Offer
Antibodies n/a Monoclonal Antibody to Receptor Accessory Protein 1 (REEP1) Monoclonal Antibody Customized Service Offer
n/a Polyclonal Antibody to Receptor Accessory Protein 1 (REEP1) Polyclonal Antibody Customized Service Offer
Assay Kits n/a CLIA Kit for Receptor Accessory Protein 1 (REEP1) CLIA Kit Customized Service Offer
n/a ELISA Kit for Receptor Accessory Protein 1 (REEP1) ELISA Kit Customized Service Offer

Organism species: Rattus norvegicus (Rat)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins n/a Recombinant Receptor Accessory Protein 1 (REEP1) Recombinant Protein Customized Service Offer
Antibodies n/a Monoclonal Antibody to Receptor Accessory Protein 1 (REEP1) Monoclonal Antibody Customized Service Offer
n/a Polyclonal Antibody to Receptor Accessory Protein 1 (REEP1) Polyclonal Antibody Customized Service Offer
Assay Kits n/a CLIA Kit for Receptor Accessory Protein 1 (REEP1) CLIA Kit Customized Service Offer
n/a ELISA Kit for Receptor Accessory Protein 1 (REEP1) ELISA Kit Customized Service Offer
  1. "RTP family members induce functional expression of mammalian odorant receptors."Cell 119:679-691(2004) [PubMed] [Europe PMC] [Abstract]
  2. "Complete sequencing and characterization of 21,243 full-length human cDNAs." Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract]
  3. "Generation and annotation of the DNA sequences of human chromosomes 2 and 4." Nature 434:724-731(2005) [PubMed] [Europe PMC] [Abstract]
  4. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
  5. "Quantitative phosphoproteomic analysis of T cell receptor signaling reveals system-wide modulation of protein-protein interactions."Sci. Signal. 2:RA46-RA46(2009) [PubMed] [Europe PMC] [Abstract]
  6. "Hereditary spastic paraplegia proteins REEP1, spastin, and atlastin-1 coordinate microtubule interactions with the tubular ER network."J. Clin. Invest. 120:1097-1110(2010) [PubMed] [Europe PMC] [Abstract]
  7. "Exome sequencing identifies a REEP1 mutation involved in distal hereditary motor neuropathy type V."Am. J. Hum. Genet. 91:139-145(2012) [PubMed] [Europe PMC] [Abstract]
  8. "Functional mutation analysis provides evidence for a role of REEP1 in lipid droplet biology."Hum. Mutat. 35:497-504(2014) [PubMed] [Europe PMC] [Abstract]
  9. "An enzyme assisted RP-RPLC approach for in-depth analysis of human liver phosphoproteome."J. Proteomics 96:253-262(2014) [PubMed] [Europe PMC] [Abstract]
  10. "Autosomal dominant hereditary spastic paraplegia: novel mutations in the REEP1 gene (SPG31)."BMC Med. Genet. 9:71-71(2008) [PubMed] [Europe PMC] [Abstract]
  11. "Mutations in the novel mitochondrial protein REEP1 cause hereditary spastic paraplegia type 31."Am. J. Hum. Genet. 79:365-369(2006) [PubMed] [Europe PMC] [Abstract]
  12. "Mutation screening of spastin, atlastin, and REEP1 in hereditary spastic paraplegia."Clin. Genet. 79:523-530(2011) [PubMed] [Europe PMC] [Abstract]
  13. "REEP1 mutations in SPG31: frequency, mutational spectrum, and potential association with mitochondrial morpho-functional dysfunction." Hum. Mutat. 32:1118-1127(2011) [PubMed] [Europe PMC] [Abstract]