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Retinol Dehydrogenase 5 (RDH5)

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RDH1; SDR9C5; HSD17b9; 9cRDH; 11-Cis Retinol Dehydrogenase; 9-cis retinol dehydrogenase; Short Chain Dehydrogenase/Reductase Family 9C,Member 5

Retinol Dehydrogenase 5 (RDH5)
CCC H242
HGNC 9940
MGI 1201412
PubMed 11078852
UniProt Q92781
Wiki RDH5
RDH5 encodes an enzyme belonging to the short-chain dehydrogenases/reductases (SDR) family. This retinol dehydrogenase functions to catalyze the final step in the biosynthesis of 11-cis retinaldehyde, which is the universal chromophore of visual pigments.
The sequence of the cDNA encoding p32 revealed that it is a member of the superfamily of short-chain alcohol dehydrogenases. The authors determined that transcripts of the gene were specifically expressed in retinal pigment epithelium. They also determined that p32 acts as a stereospecific 11-cis retinol dehydrogenase in the presence of NAD+ and that it catalyzes the final step in the biosynthesis of 11-cis retinaldehyde, the universal chromophore of visual pigments.

Organism species: Homo sapiens (Human)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins n/a Recombinant Retinol Dehydrogenase 5 (RDH5) Recombinant Protein Customized Service Offer
Antibodies n/a Monoclonal Antibody to Retinol Dehydrogenase 5 (RDH5) Monoclonal Antibody Customized Service Offer
n/a Polyclonal Antibody to Retinol Dehydrogenase 5 (RDH5) Polyclonal Antibody Customized Service Offer
Assay Kits n/a CLIA Kit for Retinol Dehydrogenase 5 (RDH5) CLIA Kit Customized Service Offer
n/a ELISA Kit for Retinol Dehydrogenase 5 (RDH5) ELISA Kit Customized Service Offer

Organism species: Mus musculus (Mouse)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins n/a Recombinant Retinol Dehydrogenase 5 (RDH5) Recombinant Protein Customized Service Offer
Antibodies n/a Monoclonal Antibody to Retinol Dehydrogenase 5 (RDH5) Monoclonal Antibody Customized Service Offer
n/a Polyclonal Antibody to Retinol Dehydrogenase 5 (RDH5) Polyclonal Antibody Customized Service Offer
Assay Kits n/a CLIA Kit for Retinol Dehydrogenase 5 (RDH5) CLIA Kit Customized Service Offer
n/a ELISA Kit for Retinol Dehydrogenase 5 (RDH5) ELISA Kit Customized Service Offer
  1. "Primary structure of human 11-cis retinol dehydrogenase and organization and chromosomal localization of the corresponding gene."Genomics 36:424-430(1996) [PubMed] [Europe PMC] [Abstract]
  2. "Identification and characterization of a stereospecific human enzyme that catalyzes 9-cis-retinol oxidation. A possible role in 9-cis-retinoic acid formation."J. Biol. Chem. 272:11744-11749(1997) [PubMed] [Europe PMC] [Abstract]
  3. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
  4. "Biochemical properties, tissue expression, and gene structure of a short chain dehydrogenase/reductase able to catalyze cis-retinol oxidation."J. Lipid Res. 40:2279-2292(1999) [PubMed] [Europe PMC] [Abstract]
  5. "Biochemical defects in 11-cis-retinol dehydrogenase mutants associated with fundus albipunctatus."J. Biol. Chem. 276:49251-49257(2001) [PubMed] [Europe PMC] [Abstract]
  6. "11-cis retinol dehydrogenase mutations as a major cause of the congenital night-blindness disorder known as fundus albipunctatus."Mol. Vis. 5:41-41(1999) [PubMed] [Europe PMC] [Abstract]
  7. "Mutations in the gene encoding 11-cis retinol dehydrogenase cause delayed dark adaptation and fundus albipunctatus."Nat. Genet. 22:188-191(1999) [PubMed] [Europe PMC] [Abstract]
  8. "A novel compound heterozygous mutation in the RDH5 gene in a patient with fundus albipunctatus."Am. J. Ophthalmol. 130:672-675(2000) [PubMed] [Europe PMC] [Abstract]
  9. "A high association with cone dystrophy in Fundus albipunctatus caused by mutations of the RDH5 gene."Invest. Ophthalmol. Vis. Sci. 41:3925-3932(2000) [PubMed] [Europe PMC] [Abstract]
  10. "Null mutation in the human 11-cis retinol dehydrogenase gene associated with fundus albipunctatus."Ophthalmology 108:1479-1484(2001) [PubMed] [Europe PMC] [Abstract]
  11. "Macular dystrophy in a Japanese family with fundus albipunctatus."Am. J. Ophthalmol. 135:917-919(2003) [PubMed] [Europe PMC] [Abstract]
  12. "A novel RDH5 gene mutation in a patient with fundus albipunctatus presenting with macular atrophy and fading white dots."Am. J. Ophthalmol. 136:572-574(2003) [PubMed] [Europe PMC] [Abstract]