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Ras Guanyl Releasing Protein 2 (RASGRP2)

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CALDAG-GEFI; CDC25L, MCG7; Calcium and DAG-regulated guanine nucleotide exchange factor I; Cdc25-like protein; F25B3.3 kinase-like protein

Ras Guanyl Releasing Protein 2 (RASGRP2)
CCC H250
HGNC 9879
MGI 1333849
PubMed 10918068
RGD 1311630
UniProt Q7LDG7
Wiki RASGRP2
RASGRP2 is a brain-enriched nucleotide exchanged factor that contains an N-terminal GEF domain, 2 tandem repeats of EF-hand calcium-binding motifs, and a C-terminal diacylglycerol/phorbol ester-binding domain. This protein can activate small GTPases, including RAS and RAP1/RAS3. The nucleotide exchange activity of this protein can be stimulated by calcium and diacylglycerol. The deduced 609-amino acid protein has an N-terminal GEF domain, 2 tandem repeats of EF-hand calcium-binding motifs, and a C-terminal diacylglycerol/phorbol ester-binding domain. Northern blot analysis detected an approximately 2.5-kb transcript in brain, with enrichment in the striatum. Immunohistochemistry showed a basal ganglia-enriched distribution pattern in adult rat brain.

Organism species: Homo sapiens (Human)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins n/a Recombinant Ras Guanyl Releasing Protein 2 (RASGRP2) Recombinant Protein Customized Service Offer
Antibodies n/a Monoclonal Antibody to Ras Guanyl Releasing Protein 2 (RASGRP2) Monoclonal Antibody Customized Service Offer
n/a Polyclonal Antibody to Ras Guanyl Releasing Protein 2 (RASGRP2) Polyclonal Antibody Customized Service Offer
Assay Kits SEH250Hu ELISA Kit for Ras Guanyl Releasing Protein 2 (RASGRP2) Enzyme-linked immunosorbent assay for Antigen Detection.

Organism species: Mus musculus (Mouse)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins n/a Recombinant Ras Guanyl Releasing Protein 2 (RASGRP2) Recombinant Protein Customized Service Offer
Antibodies n/a Monoclonal Antibody to Ras Guanyl Releasing Protein 2 (RASGRP2) Monoclonal Antibody Customized Service Offer
n/a Polyclonal Antibody to Ras Guanyl Releasing Protein 2 (RASGRP2) Polyclonal Antibody Customized Service Offer
Assay Kits n/a CLIA Kit for Ras Guanyl Releasing Protein 2 (RASGRP2) CLIA Kit Customized Service Offer
n/a ELISA Kit for Ras Guanyl Releasing Protein 2 (RASGRP2) ELISA Kit Customized Service Offer

Organism species: Rattus norvegicus (Rat)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins n/a Recombinant Ras Guanyl Releasing Protein 2 (RASGRP2) Recombinant Protein Customized Service Offer
Antibodies n/a Monoclonal Antibody to Ras Guanyl Releasing Protein 2 (RASGRP2) Monoclonal Antibody Customized Service Offer
n/a Polyclonal Antibody to Ras Guanyl Releasing Protein 2 (RASGRP2) Polyclonal Antibody Customized Service Offer
Assay Kits n/a CLIA Kit for Ras Guanyl Releasing Protein 2 (RASGRP2) CLIA Kit Customized Service Offer
n/a ELISA Kit for Ras Guanyl Releasing Protein 2 (RASGRP2) ELISA Kit Customized Service Offer
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  12. "LAD-1/variant syndrome is caused by mutations in FERMT3."Blood 113:4740-4746(2009) [PubMed] [Europe PMC] [Abstract]
  13. "Leukocyte adhesion deficiency-III is caused by mutations in KINDLIN3 affecting integrin activation."Nat. Med. 15:306-312(2009) [PubMed] [Europe PMC] [Abstract]
  14. "A point mutation in KINDLIN3 ablates activation of three integrin subfamilies in humans."Nat. Med. 15:313-318(2009) [PubMed] [Europe PMC] [Abstract]
  15. "Human CalDAG-GEFI gene (RASGRP2) mutation affects platelet function and causes severe bleeding."J. Exp. Med. 211:1349-1362(2014) [PubMed] [Europe PMC] [Abstract]
  16. "Structural analysis of autoinhibition in the Ras-specific exchange factor RasGRP1."Elife 2:E00813-E00813(2013) [PubMed] [Europe PMC] [Abstract]