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Ral Guanine Nucleotide Dissociation Stimulator (RALGDS)

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RGF; RalGEF; Ral guanine nucleotide exchange factor

Ral Guanine Nucleotide Dissociation Stimulator (RALGDS)
CCC H264
HGNC 9842
MGI 107485
PubMed 9365783
RGD 3533
UniProt Q12967
Wiki RALGDS
Ras-related GTPases participate in signaling for a variety of cellular processes and are regulated in part by guanine nucleotide dissociation stimulators (GDSs, or exchange factors). Albright et al. (1993) used sequences derived from the yeast rasGDS proteins as probes and cloned cDNAs encoding a novel murine GDS protein.
The protein stimulated the dissociation of guanine nucleotides from the ralA and ralB GTPases. The protein, designated RalGDS by them, was at least 20-fold more active on the ralA and ralB GTPases than any other GTPases tested. The 3.6-kb ralGDS mRNA and the 115-kD ralGDS protein were found in all tissues examined.

Organism species: Homo sapiens (Human)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins n/a Recombinant Ral Guanine Nucleotide Dissociation Stimulator (RALGDS) Recombinant Protein Customized Service Offer
Antibodies n/a Monoclonal Antibody to Ral Guanine Nucleotide Dissociation Stimulator (RALGDS) Monoclonal Antibody Customized Service Offer
n/a Polyclonal Antibody to Ral Guanine Nucleotide Dissociation Stimulator (RALGDS) Polyclonal Antibody Customized Service Offer
Assay Kits n/a CLIA Kit for Ral Guanine Nucleotide Dissociation Stimulator (RALGDS) CLIA Kit Customized Service Offer
n/a ELISA Kit for Ral Guanine Nucleotide Dissociation Stimulator (RALGDS) ELISA Kit Customized Service Offer

Organism species: Mus musculus (Mouse)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins n/a Recombinant Ral Guanine Nucleotide Dissociation Stimulator (RALGDS) Recombinant Protein Customized Service Offer
Antibodies n/a Monoclonal Antibody to Ral Guanine Nucleotide Dissociation Stimulator (RALGDS) Monoclonal Antibody Customized Service Offer
n/a Polyclonal Antibody to Ral Guanine Nucleotide Dissociation Stimulator (RALGDS) Polyclonal Antibody Customized Service Offer
Assay Kits n/a CLIA Kit for Ral Guanine Nucleotide Dissociation Stimulator (RALGDS) CLIA Kit Customized Service Offer
n/a ELISA Kit for Ral Guanine Nucleotide Dissociation Stimulator (RALGDS) ELISA Kit Customized Service Offer

Organism species: Rattus norvegicus (Rat)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins n/a Recombinant Ral Guanine Nucleotide Dissociation Stimulator (RALGDS) Recombinant Protein Customized Service Offer
Antibodies n/a Monoclonal Antibody to Ral Guanine Nucleotide Dissociation Stimulator (RALGDS) Monoclonal Antibody Customized Service Offer
n/a Polyclonal Antibody to Ral Guanine Nucleotide Dissociation Stimulator (RALGDS) Polyclonal Antibody Customized Service Offer
Assay Kits n/a CLIA Kit for Ral Guanine Nucleotide Dissociation Stimulator (RALGDS) CLIA Kit Customized Service Offer
n/a ELISA Kit for Ral Guanine Nucleotide Dissociation Stimulator (RALGDS) ELISA Kit Customized Service Offer
  1. "Cloning and evaluation of RALGDS as a candidate for the tuberous sclerosis gene TSC1."Ann. Hum. Genet. 61:299-305(1997) [PubMed] [Europe PMC] [Abstract]
  2. "Complete sequencing and characterization of 21,243 full-length human cDNAs." Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract]
  3. "DNA sequence and analysis of human chromosome 9." Nature 429:369-374(2004) [PubMed] [Europe PMC] [Abstract]
  4. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
  5. "Prediction of the coding sequences of unidentified human genes. XVI. The complete sequences of 150 new cDNA clones from brain which code for large proteins in vitro."DNA Res. 7:65-73(2000) [PubMed] [Europe PMC] [Abstract]
  6. "Activated Ras interacts with the Ral guanine nucleotide dissociation stimulator."Proc. Natl. Acad. Sci. U.S.A. 91:11089-11093(1994) [PubMed] [Europe PMC] [Abstract]
  7. "Structure of the Ras-binding domain of RalGEF and implications for Ras binding and signalling."Nat. Struct. Biol. 4:694-699(1997) [PubMed] [Europe PMC] [Abstract]
  8. "High-resolution structure of the RA-domain of human RalGDS and a dynamics study of its binding loop to Ras."Submitted (MAR-1999) to the PDB data bank
  9. "The consensus coding sequences of human breast and colorectal cancers." Science 314:268-274(2006) [PubMed] [Europe PMC] [Abstract]