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RAB Interacting Factor (RABIF)

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RASGRF3; Mss4; Guanine nucleotide exchange factor MSS4

RAB Interacting Factor (RABIF)
CCC H272
HGNC 9797
MGI 2138605
PubMed 9441742
RGD 1563962
UniProt P47224
Wiki RABIF
The Sec4/Rab-related small GTP-binding proteins are involved in the regulation of intracellular vesicular transport. Mss4 stimulates GTP-GDP exchange in Sec4 and Rab and binds to a subset of genetically related Rab proteins.The gene encodes a 123-amino acid polypeptide that requires zinc for stability.
MSS4 is expressed as 3 differently sized mRNAs, probably due to alternative polyadenylation signals. The transcripts are present at barely detectable levels in healthy pancreas, but at much higher levels in pancreatic and other cancer tissues.MSS4 bound specifically to integrins containing an aromatic amino acid before the first lysine of the conserved motif. These integrins included alpha-2 , alpha-3A, alpha-3B, alpha-5, and alpha-6A.

Organism species: Homo sapiens (Human)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins n/a Recombinant RAB Interacting Factor (RABIF) Recombinant Protein Customized Service Offer
Antibodies n/a Monoclonal Antibody to RAB Interacting Factor (RABIF) Monoclonal Antibody Customized Service Offer
n/a Polyclonal Antibody to RAB Interacting Factor (RABIF) Polyclonal Antibody Customized Service Offer
Assay Kits n/a CLIA Kit for RAB Interacting Factor (RABIF) CLIA Kit Customized Service Offer
n/a ELISA Kit for RAB Interacting Factor (RABIF) ELISA Kit Customized Service Offer

Organism species: Mus musculus (Mouse)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins n/a Recombinant RAB Interacting Factor (RABIF) Recombinant Protein Customized Service Offer
Antibodies n/a Monoclonal Antibody to RAB Interacting Factor (RABIF) Monoclonal Antibody Customized Service Offer
n/a Polyclonal Antibody to RAB Interacting Factor (RABIF) Polyclonal Antibody Customized Service Offer
Assay Kits n/a CLIA Kit for RAB Interacting Factor (RABIF) CLIA Kit Customized Service Offer
n/a ELISA Kit for RAB Interacting Factor (RABIF) ELISA Kit Customized Service Offer

Organism species: Rattus norvegicus (Rat)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins n/a Recombinant RAB Interacting Factor (RABIF) Recombinant Protein Customized Service Offer
Antibodies n/a Monoclonal Antibody to RAB Interacting Factor (RABIF) Monoclonal Antibody Customized Service Offer
n/a Polyclonal Antibody to RAB Interacting Factor (RABIF) Polyclonal Antibody Customized Service Offer
Assay Kits n/a CLIA Kit for RAB Interacting Factor (RABIF) CLIA Kit Customized Service Offer
n/a ELISA Kit for RAB Interacting Factor (RABIF) ELISA Kit Customized Service Offer
  1. "Cloning, Zn2+ binding, and structural characterization of the guanine nucleotide exchange factor human Mss4."Biochemistry 34:9103-9110(1995) [PubMed] [Europe PMC] [Abstract]
  2. "Cloning of novel transcripts of the human guanine-nucleotide-exchange factor Mss4: in situ chromosomal mapping and expression in pancreatic cancer."Genomics 46:389-396(1997) [PubMed] [Europe PMC] [Abstract]
  3. "Complete sequencing and characterization of 21,243 full-length human cDNAs." Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract]
  4. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
  5. "Initial characterization of the human central proteome."BMC Syst. Biol. 5:17-17(2011) [PubMed] [Europe PMC] [Abstract]
  6. "Comparative large-scale characterisation of plant vs. mammal proteins reveals similar and idiosyncratic N-alpha acetylation features."Mol. Cell. Proteomics 11:M111.015131-M111.015131(2012) [PubMed] [Europe PMC] [Abstract]
  7. "N-terminal acetylome analyses and functional insights of the N-terminal acetyltransferase NatB."Proc. Natl. Acad. Sci. U.S.A. 109:12449-12454(2012) [PubMed] [Europe PMC] [Abstract]
  8. "Structure of guanine-nucleotide-exchange factor human Mss4 and identification of its Rab-interacting surface."Nature 376:788-791(1995) [PubMed] [Europe PMC] [Abstract]
  9. "Nucleotide exchange via local protein unfolding--structure of Rab8 in complex with MSS4."EMBO J. 25:1445-1455(2006) [PubMed] [Europe PMC] [Abstract]