Pituitary Tumor Transforming 2 (PTTG2)

PTTG2 is a homolog of yeast securin proteins, which prevent separins from promoting sister chromatid separation. It is an anaphase-promoting complex (APC) substrate that associates with a separin until activation of the APC.

During the course of studies mapping the PTTG1 gene to 5q33, Prezant et al. (1999) found evidence for a related intronless gene, which they referred to as PTTG2, on chromosome 4. They stated that PTTG1 and PTTG2 are highly conserved at both the nucleotide and amino acid levels, including the potential SH3 binding domain. They found low-level PTTG2 expression in normal pituitary and in some other normal tissues, and moderately elevated expression in some pituitary tumors. By radiation hybrid mapping, Prezant et al. (1999) mapped the PTTG2 gene to human chromosome 4p12.