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Pituitary Tumor Transforming 1 Interacting Protein (PTTG1IP)

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PBF; C21orf1; C21orf3; Pituitary tumor-transforming gene protein-binding factor

Pituitary Tumor Transforming 1 Interacting Protein (PTTG1IP)
CCC H280
HGNC 13524
MGI 2652132
PubMed 21844185
RGD 1305983
UniProt P53801
Wiki PTTG1IP
PTTG1IP, which directly binds to pituitary tumor-transforming gene 1 protein (PTTG1), facilitates the nuclear translocation of PTTG1 and potentiates the transcriptional activation of basic fibroblast growth factor by PTTG1. The gene product localizes to both the cytoplasm and nucleus. Its NLS is required for its own nuclear localization, the nuclear localization of PTTG1, and its interaction with PTTG1.
The predicted 180-amino acid C21ORF3 protein has features of a type Ia integral membrane protein and contains the tetrapeptide YXRF, a motif observed in proteins internalized via coated pit-mediated endocytosis. Northern blot analysis detected a 2.69-kb C21ORF3 mRNA in all tissues examined.

Organism species: Homo sapiens (Human)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins RPH280Hu01 Recombinant Pituitary Tumor Transforming 1 Interacting Protein (PTTG1IP) Positive Control; Immunogen; SDS-PAGE; WB.
Antibodies PAH280Hu01 Polyclonal Antibody to Pituitary Tumor Transforming 1 Interacting Protein (PTTG1IP) WB; IHC; ICC; IP.
MAH280Hu21 Monoclonal Antibody to Pituitary Tumor Transforming 1 Interacting Protein (PTTG1IP) WB; IHC; ICC; IP.
Assay Kits SEH280Hu ELISA Kit for Pituitary Tumor Transforming 1 Interacting Protein (PTTG1IP) Enzyme-linked immunosorbent assay for Antigen Detection.

Organism species: Mus musculus (Mouse)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins n/a Recombinant Pituitary Tumor Transforming 1 Interacting Protein (PTTG1IP) Recombinant Protein Customized Service Offer
Antibodies n/a Monoclonal Antibody to Pituitary Tumor Transforming 1 Interacting Protein (PTTG1IP) Monoclonal Antibody Customized Service Offer
n/a Polyclonal Antibody to Pituitary Tumor Transforming 1 Interacting Protein (PTTG1IP) Polyclonal Antibody Customized Service Offer
Assay Kits n/a CLIA Kit for Pituitary Tumor Transforming 1 Interacting Protein (PTTG1IP) CLIA Kit Customized Service Offer
n/a ELISA Kit for Pituitary Tumor Transforming 1 Interacting Protein (PTTG1IP) ELISA Kit Customized Service Offer

Organism species: Rattus norvegicus (Rat)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins n/a Recombinant Pituitary Tumor Transforming 1 Interacting Protein (PTTG1IP) Recombinant Protein Customized Service Offer
Antibodies n/a Monoclonal Antibody to Pituitary Tumor Transforming 1 Interacting Protein (PTTG1IP) Monoclonal Antibody Customized Service Offer
n/a Polyclonal Antibody to Pituitary Tumor Transforming 1 Interacting Protein (PTTG1IP) Polyclonal Antibody Customized Service Offer
Assay Kits n/a CLIA Kit for Pituitary Tumor Transforming 1 Interacting Protein (PTTG1IP) CLIA Kit Customized Service Offer
n/a ELISA Kit for Pituitary Tumor Transforming 1 Interacting Protein (PTTG1IP) ELISA Kit Customized Service Offer
  1. "Cloning of a novel human putative type Ia integral membrane protein mapping to 21q22.3."Genomics 49:133-136(1998) [PubMed] [Europe PMC] [Abstract]
  2. "A novel binding factor facilitates nuclear translocation and transcriptional activation function of the pituitary tumor-transforming gene product."J. Biol. Chem. 275:19422-19427(2000) [PubMed] [Europe PMC] [Abstract]
  3. "Complete sequencing and characterization of 21,243 full-length human cDNAs." Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract]
  4. "The DNA sequence of human chromosome 21." Nature 405:311-319(2000) [PubMed] [Europe PMC] [Abstract]
  5. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
  6. "Identification of novel genes of the bone-specific transcription factor Runx2."J. Bone Miner. Res. 19:959-972(2004) [PubMed] [Europe PMC] [Abstract]