Phosphatidylserine Synthase 2 (PTDSS2)

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PSS2; Serine-exchange enzyme II

Phosphatidylserine Synthase 2 (PTDSS2)
Phosphatidylserine (PS) accounts for 5 to 10% of cell membrane phospholipids. In addition to its role as a structural component, PS is involved in cell signaling, blood coagulation, and apoptosis. PS is synthesized by a calcium-dependent base-exchange reaction catalyzed by PS synthases (EC 2.7.8.8), like PTDSS2, that exchange L-serine for the polar head group of phosphatidylcholine (PC) or phosphatidylethanolamine (PE) .
Pss1 and Pss2 localized exclusively to the mitochondrial-associated membrane (MAM) subcompartment of the endoplasmic reticulum (ER) in rodent cell lines and in mouse liver. Mouse liver MAM used PC and PE as substrates for PS biosynthesis, whereas ER membranes used only PE.

Organism species: Homo sapiens (Human)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins n/a Recombinant Phosphatidylserine Synthase 2 (PTDSS2) Recombinant Protein Customized Service Offer
Antibodies n/a Monoclonal Antibody to Phosphatidylserine Synthase 2 (PTDSS2) Monoclonal Antibody Customized Service Offer
n/a Polyclonal Antibody to Phosphatidylserine Synthase 2 (PTDSS2) Polyclonal Antibody Customized Service Offer
Assay Kits n/a CLIA Kit for Phosphatidylserine Synthase 2 (PTDSS2) CLIA Kit Customized Service Offer
n/a ELISA Kit for Phosphatidylserine Synthase 2 (PTDSS2) ELISA Kit Customized Service Offer

Organism species: Mus musculus (Mouse)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins n/a Recombinant Phosphatidylserine Synthase 2 (PTDSS2) Recombinant Protein Customized Service Offer
Antibodies n/a Monoclonal Antibody to Phosphatidylserine Synthase 2 (PTDSS2) Monoclonal Antibody Customized Service Offer
n/a Polyclonal Antibody to Phosphatidylserine Synthase 2 (PTDSS2) Polyclonal Antibody Customized Service Offer
Assay Kits n/a CLIA Kit for Phosphatidylserine Synthase 2 (PTDSS2) CLIA Kit Customized Service Offer
n/a ELISA Kit for Phosphatidylserine Synthase 2 (PTDSS2) ELISA Kit Customized Service Offer

Organism species: Rattus norvegicus (Rat)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins n/a Recombinant Phosphatidylserine Synthase 2 (PTDSS2) Recombinant Protein Customized Service Offer
Antibodies n/a Monoclonal Antibody to Phosphatidylserine Synthase 2 (PTDSS2) Monoclonal Antibody Customized Service Offer
n/a Polyclonal Antibody to Phosphatidylserine Synthase 2 (PTDSS2) Polyclonal Antibody Customized Service Offer
Assay Kits n/a CLIA Kit for Phosphatidylserine Synthase 2 (PTDSS2) CLIA Kit Customized Service Offer
n/a ELISA Kit for Phosphatidylserine Synthase 2 (PTDSS2) ELISA Kit Customized Service Offer
  1. "The full-ORF clone resource of the German cDNA consortium."BMC Genomics 8:399-399(2007) [PubMed] [Europe PMC] [Abstract]
  2. "DNA sequence and analysis of human chromosome 8." Nature 439:331-335(2006) [PubMed] [Europe PMC] [Abstract]
  3. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
  4. "Global, in vivo, and site-specific phosphorylation dynamics in signaling networks."Cell 127:635-648(2006) [PubMed] [Europe PMC] [Abstract]
  5. "Phosphoproteome of resting human platelets."J. Proteome Res. 7:526-534(2008) [PubMed] [Europe PMC] [Abstract]
  6. "Kinase-selective enrichment enables quantitative phosphoproteomics of the kinome across the cell cycle."Mol. Cell 31:438-448(2008) [PubMed] [Europe PMC] [Abstract]
  7. "A quantitative atlas of mitotic phosphorylation."Proc. Natl. Acad. Sci. U.S.A. 105:10762-10767(2008) [PubMed] [Europe PMC] [Abstract]
  8. "Purification and characterization of human phosphatidylserine synthases 1 and 2."Biochem. J. 418:421-429(2009) [PubMed] [Europe PMC] [Abstract]
  9. "Glycoproteomics analysis of human liver tissue by combination of multiple enzyme digestion and hydrazide chemistry."J. Proteome Res. 8:651-661(2009) [PubMed] [Europe PMC] [Abstract]
  10. "Large-scale proteomics analysis of the human kinome."Mol. Cell. Proteomics 8:1751-1764(2009) [PubMed] [Europe PMC] [Abstract]
  11. "Quantitative phosphoproteomics reveals widespread full phosphorylation site occupancy during mitosis."Sci. Signal. 3:RA3-RA3(2010) [PubMed] [Europe PMC] [Abstract]
  12. "System-wide temporal characterization of the proteome and phosphoproteome of human embryonic stem cell differentiation."Sci. Signal. 4:RS3-RS3(2011) [PubMed] [Europe PMC] [Abstract]
  13. "An enzyme assisted RP-RPLC approach for in-depth analysis of human liver phosphoproteome."J. Proteomics 96:253-262(2014) [PubMed] [Europe PMC] [Abstract]