Phosphoribosyl Pyrophosphate Synthetase 1 (PRPS1)
[Edit]CMTX5; PRS I; PPRibP; Ribose-Phosphate Diphosphokinase 1
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PRPS1 encodes an enzyme that catalyzes the phosphoribosylation of ribose 5-phosphate to 5-phosphoribosyl-1-pyrophosphate, which is necessary for purine metabolism and nucleotide biosynthesis. Defects in this gene are a cause of phosphoribosylpyrophosphate synthetase superactivity, Charcot-Marie-Tooth disease X-linked recessive type 5 and Arts Syndrome.
The deduced PRPS1 protein has 318 amino acids and shares 95% amino acid homology with PRPS2.PRPS1 amino acid sequence shows an exceptionally high degree of conservation, with homologies greater than 95% across different species from zebrafish to human.
Organism species: Homo sapiens (Human)
| CATALOG NO. | PRODUCT NAME | APPLICATIONS | |
| Proteins | n/a | Recombinant Phosphoribosyl Pyrophosphate Synthetase 1 (PRPS1) | Recombinant Protein Customized Service Offer |
| Antibodies | n/a | Monoclonal Antibody to Phosphoribosyl Pyrophosphate Synthetase 1 (PRPS1) | Monoclonal Antibody Customized Service Offer |
| n/a | Polyclonal Antibody to Phosphoribosyl Pyrophosphate Synthetase 1 (PRPS1) | Polyclonal Antibody Customized Service Offer | |
| Assay Kits | n/a | CLIA Kit for Phosphoribosyl Pyrophosphate Synthetase 1 (PRPS1) | CLIA Kit Customized Service Offer |
| n/a | ELISA Kit for Phosphoribosyl Pyrophosphate Synthetase 1 (PRPS1) | ELISA Kit Customized Service Offer |
Organism species: Mus musculus (Mouse)
| CATALOG NO. | PRODUCT NAME | APPLICATIONS | |
| Proteins | n/a | Recombinant Phosphoribosyl Pyrophosphate Synthetase 1 (PRPS1) | Recombinant Protein Customized Service Offer |
| Antibodies | n/a | Monoclonal Antibody to Phosphoribosyl Pyrophosphate Synthetase 1 (PRPS1) | Monoclonal Antibody Customized Service Offer |
| n/a | Polyclonal Antibody to Phosphoribosyl Pyrophosphate Synthetase 1 (PRPS1) | Polyclonal Antibody Customized Service Offer | |
| Assay Kits | n/a | CLIA Kit for Phosphoribosyl Pyrophosphate Synthetase 1 (PRPS1) | CLIA Kit Customized Service Offer |
| n/a | ELISA Kit for Phosphoribosyl Pyrophosphate Synthetase 1 (PRPS1) | ELISA Kit Customized Service Offer |
Organism species: Rattus norvegicus (Rat)
| CATALOG NO. | PRODUCT NAME | APPLICATIONS | |
| Proteins | n/a | Recombinant Phosphoribosyl Pyrophosphate Synthetase 1 (PRPS1) | Recombinant Protein Customized Service Offer |
| Antibodies | n/a | Monoclonal Antibody to Phosphoribosyl Pyrophosphate Synthetase 1 (PRPS1) | Monoclonal Antibody Customized Service Offer |
| n/a | Polyclonal Antibody to Phosphoribosyl Pyrophosphate Synthetase 1 (PRPS1) | Polyclonal Antibody Customized Service Offer | |
| Assay Kits | n/a | CLIA Kit for Phosphoribosyl Pyrophosphate Synthetase 1 (PRPS1) | CLIA Kit Customized Service Offer |
| n/a | ELISA Kit for Phosphoribosyl Pyrophosphate Synthetase 1 (PRPS1) | ELISA Kit Customized Service Offer |
- "Cloning of two distinct copies of human phosphoribosylpyrophosphate synthetase cDNA."Nucleic Acids Res. 18:193-193(1990) [PubMed] [Europe PMC] [Abstract]
- "Complete nucleotide sequence of human phosphoribosyl pyrophosphate synthetase subunit I (PRS I) cDNA and a comparison with human and rat PRPS gene families."J. Biochem. 109:361-364(1991) [PubMed] [Europe PMC] [Abstract]
- "Complete sequencing and characterization of 21,243 full-length human cDNAs." Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract]
- "The DNA sequence of the human X chromosome." Nature 434:325-337(2005) [PubMed] [Europe PMC] [Abstract]
- "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
- "Promoter regions of the human X-linked housekeeping genes PRPS1 and PRPS2 encoding phosphoribosylpyrophosphate synthetase subunit I and II isoforms."Biochim. Biophys. Acta 1130:139-148(1992) [PubMed] [Europe PMC] [Abstract]