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Protamine 1 (PRM1)

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CT94.1; Cancer/Testis Antigen Family 94,Member 1; Sperm protamine P1; Cysteine-rich protamine

Protamine 1 (PRM1)
CCC H308
HGNC 9447
MGI 97765
PubMed 17943087
RGD 1583873
UniProt P04553
Protamines are small, arginine-rich, nuclear proteins that replace histones late in the haploid phase of spermatogenesis and are believed essential for sperm head condensation and DNA stabilization. Mice, humans, and certain fish have 2 or more different protamines, whereas the sperm of bull, boar, rat, rabbit, guinea pig, and ram have one form of protamine. The 2 human protamines are denoted P1 and P2 (PRM2).
PRM1 and PRM2 have a single intron, consisting of 91 and 163 bp, respectively. Both genes were found to contain typical TATAA and CAAT boxes at conventional distances from the transcription start points which, by use of primary extension experiments, were assigned to nucleotides -91 and -110 for PRM1 and PRM2, respectively.

Organism species: Homo sapiens (Human)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins RPH308Hu01 Recombinant Protamine 1 (PRM1) Positive Control; Immunogen; SDS-PAGE; WB.
Antibodies MAH308Hu21 Monoclonal Antibody to Protamine 1 (PRM1) WB; IHC; ICC; IP.
PAH308Hu01 Polyclonal Antibody to Protamine 1 (PRM1) WB; IHC; ICC; IP.
Assay Kits SEH308Hu ELISA Kit for Protamine 1 (PRM1) Enzyme-linked immunosorbent assay for Antigen Detection.

Organism species: Mus musculus (Mouse)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins n/a Recombinant Protamine 1 (PRM1) Recombinant Protein Customized Service Offer
Antibodies n/a Monoclonal Antibody to Protamine 1 (PRM1) Monoclonal Antibody Customized Service Offer
n/a Polyclonal Antibody to Protamine 1 (PRM1) Polyclonal Antibody Customized Service Offer
Assay Kits n/a CLIA Kit for Protamine 1 (PRM1) CLIA Kit Customized Service Offer
n/a ELISA Kit for Protamine 1 (PRM1) ELISA Kit Customized Service Offer

Organism species: Rattus norvegicus (Rat)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins n/a Recombinant Protamine 1 (PRM1) Recombinant Protein Customized Service Offer
Antibodies n/a Monoclonal Antibody to Protamine 1 (PRM1) Monoclonal Antibody Customized Service Offer
n/a Polyclonal Antibody to Protamine 1 (PRM1) Polyclonal Antibody Customized Service Offer
Assay Kits n/a CLIA Kit for Protamine 1 (PRM1) CLIA Kit Customized Service Offer
n/a ELISA Kit for Protamine 1 (PRM1) ELISA Kit Customized Service Offer
  1. "Genomic sequences of human protamines whose genes, PRM1 and PRM2, are clustered."Genomics 8:127-133(1990) [PubMed] [Europe PMC] [Abstract]
  2. "Chromosomal localization and structure of the human P1 protamine gene."Genomics 5:639-645(1989) [PubMed] [Europe PMC] [Abstract]
  3. "The nucleotide sequence of a human protamine 1 cDNA."Nucleic Acids Res. 15:7639-7639(1987) [PubMed] [Europe PMC] [Abstract]
  4. "Characterization of a human locus in transition."J. Biol. Chem. 269:31067-31073(1994) [PubMed] [Europe PMC] [Abstract]
  5. "Direct sequencing of the human protamine P1 gene and application in forensic medicine."J. Forensic Sci. 38:1491-1501(1993) [PubMed] [Europe PMC] [Abstract]
  6. "Rapid evolution of male reproductive genes in the descent of man."Nature 403:304-309(2000) [PubMed] [Europe PMC] [Abstract]
  7. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
  8. "The amino acid sequence of human sperm protamine P1."Biosci. Rep. 5:383-391(1985) [PubMed] [Europe PMC] [Abstract]
  9. "Isolation and amino-acid sequence analysis of human sperm protamines P1 and P2. Occurrence of two forms of protamine P2."Biol. Chem. Hoppe-Seyler 367:515-522(1986) [PubMed] [Europe PMC] [Abstract]
  10. "SR protein-specific kinase 1 is highly expressed in testis and phosphorylates protamine 1."Nucleic Acids Res. 27:2972-2980(1999) [PubMed] [Europe PMC] [Abstract]