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Protein Kinase, cGMP Dependent Type II (PRKG2)

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PRKGR2; cGKII; cGMP-dependent protein kinase 2

Protein Kinase, cGMP Dependent Type II (PRKG2)
CCC H313
HGNC 9416
MGI 108173
PubMed 18166785
RGD 3401
UniProt Q13237
Pfeifer et al. (1996) noted that there are 2 forms of cGMP-dependent protein kinase (cGK), types I and II, which are encoded by distinct genes. Smooth muscle, platelets, and cerebellum contain high concentrations of cGKI, whereas cGKII is highly concentrated in brain, lung, and intestinal mucosa.
Orstavik et al. (1996) cloned a human cDNA encoding type II cGK by using the mouse type II cGK cDNA to probe a cerebellum cDNA library. The 762-amino acid human type II cGK protein is 96% identical to the mouse and rat type II cGK proteins. Human type II cGK is expressed as a 6-kb mRNA in prostate, small intestine, and colon and as a 4.4-kb mRNA in thymus and prostate.

Organism species: Homo sapiens (Human)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins RPH313Hu01 Recombinant Protein Kinase, cGMP Dependent Type II (PRKG2) Positive Control; Immunogen; SDS-PAGE; WB.
APH313Hu01 Active Protein Kinase, cGMP Dependent Type II (PRKG2) Cell culture; Activity Assays.
Antibodies PAH313Hu01 Polyclonal Antibody to Protein Kinase, cGMP Dependent Type II (PRKG2) WB; IHC; ICC; IP.
MAH313Hu21 Monoclonal Antibody to Protein Kinase, cGMP Dependent Type II (PRKG2) WB; IHC; ICC; IP.
Assay Kits SEH313Hu ELISA Kit for Protein Kinase, cGMP Dependent Type II (PRKG2) Enzyme-linked immunosorbent assay for Antigen Detection.

Organism species: Mus musculus (Mouse)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins n/a Recombinant Protein Kinase, cGMP Dependent Type II (PRKG2) Recombinant Protein Customized Service Offer
Antibodies n/a Monoclonal Antibody to Protein Kinase, cGMP Dependent Type II (PRKG2) Monoclonal Antibody Customized Service Offer
n/a Polyclonal Antibody to Protein Kinase, cGMP Dependent Type II (PRKG2) Polyclonal Antibody Customized Service Offer
Assay Kits SEH313Mu ELISA Kit for Protein Kinase, cGMP Dependent Type II (PRKG2) Enzyme-linked immunosorbent assay for Antigen Detection.

Organism species: Rattus norvegicus (Rat)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins n/a Recombinant Protein Kinase, cGMP Dependent Type II (PRKG2) Recombinant Protein Customized Service Offer
Antibodies n/a Monoclonal Antibody to Protein Kinase, cGMP Dependent Type II (PRKG2) Monoclonal Antibody Customized Service Offer
n/a Polyclonal Antibody to Protein Kinase, cGMP Dependent Type II (PRKG2) Polyclonal Antibody Customized Service Offer
Assay Kits n/a CLIA Kit for Protein Kinase, cGMP Dependent Type II (PRKG2) CLIA Kit Customized Service Offer
n/a ELISA Kit for Protein Kinase, cGMP Dependent Type II (PRKG2) ELISA Kit Customized Service Offer
  1. "Molecular cloning, cDNA structure, and chromosomal localization of the human type II cGMP-dependent protein kinase."Biochem. Biophys. Res. Commun. 220:759-765(1996) [PubMed] [Europe PMC] [Abstract]
  2. "Expression of the human cGMP-dependent protein kinase II gene is lost upon introduction of SV40 T antigen or immortalization in human cells."FEBS Lett. 375:263-267(1995) [PubMed] [Europe PMC] [Abstract]
  3. "Complete sequencing and characterization of 21,243 full-length human cDNAs." Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract]
  4. "Generation and annotation of the DNA sequences of human chromosomes 2 and 4." Nature 434:724-731(2005) [PubMed] [Europe PMC] [Abstract]
  5. "Characterization of the gene encoding the human type II cGMP-dependent protein kinase."Biochem. Biophys. Res. Commun. 245:113-119(1998) [PubMed] [Europe PMC] [Abstract]
  6. "N-terminal myristoylation is required for membrane localization of cGMP-dependent protein kinase type II."J. Biol. Chem. 271:7025-7029(1996) [PubMed] [Europe PMC] [Abstract]
  7. "An enzyme assisted RP-RPLC approach for in-depth analysis of human liver phosphoproteome."J. Proteomics 96:253-262(2014) [PubMed] [Europe PMC] [Abstract]
  8. "Patterns of somatic mutation in human cancer genomes." Nature 446:153-158(2007) [PubMed] [Europe PMC] [Abstract]