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Protein Kinase, cGMP Dependent Type I (PRKG1)

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CGKI; PGK; PRKG1B; PRKGR1B; cGKI-BETA; cGKI-alpha; cGMP-dependent protein kinase 1

Protein Kinase, cGMP Dependent Type I (PRKG1)
CCC H314
HGNC 9414
MGI 108174
PubMed 23910461
UniProt Q13976
Wiki PRKG1
Two main forms of cGK have been identified: a soluble form designated type I and an intrinsic membrane-bound form designated type II.
Prkg1 knockout mice showed impaired platelet responses to VWF or low doses of thrombin and prolonged bleeding time. Human platelet aggregation induced by VWF or low-dose thrombin was inhibited by PRKG1 inhibitors but enhanced by cGMP. Furthermore, a cGMP-enhancing agent, sildenafil, promoted VWF- or thrombin-induced platelet aggregation. The cGMP-stimulated platelet responses were biphasic, consisting of an initial transient stimulatory response that promoted platelet aggregation and a subsequent inhibitory response that limited the size of thrombi.

Organism species: Homo sapiens (Human)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins RPH314Hu01 Recombinant Protein Kinase, cGMP Dependent Type I (PRKG1) Positive Control; Immunogen; SDS-PAGE; WB.
Antibodies PAH314Hu01 Polyclonal Antibody to Protein Kinase, cGMP Dependent Type I (PRKG1) WB; IHC; ICC; IP.
MAH314Hu21 Monoclonal Antibody to Protein Kinase, cGMP Dependent Type I (PRKG1) WB; IHC; ICC; IP.
Assay Kits SEH314Hu ELISA Kit for Protein Kinase, cGMP Dependent Type I (PRKG1) Enzyme-linked immunosorbent assay for Antigen Detection.

Organism species: Mus musculus (Mouse)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins RPH314Mu01 Recombinant Protein Kinase, cGMP Dependent Type I (PRKG1) Positive Control; Immunogen; SDS-PAGE; WB.
RPH314Mu02 Recombinant Protein Kinase, cGMP Dependent Type I (PRKG1) Positive Control; Immunogen; SDS-PAGE; WB.
Antibodies PAH314Mu01 Polyclonal Antibody to Protein Kinase, cGMP Dependent Type I (PRKG1) WB; IHC; ICC; IP.
PAH314Mu02 Polyclonal Antibody to Protein Kinase, cGMP Dependent Type I (PRKG1) WB; IHC; ICC; IP.
Assay Kits SEH314Mu ELISA Kit for Protein Kinase, cGMP Dependent Type I (PRKG1) Enzyme-linked immunosorbent assay for Antigen Detection.
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