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Protein Regulator Of Cytokinesis 1 (PRC1)

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ASE1; Anaphase Spindle Elongation 1 Homolog

Protein Regulator Of Cytokinesis 1 (PRC1)
CCC H322
HGNC 9341
MGI 1858961
PubMed 22325148
RGD 1311754
UniProt O43663
Wiki PRC1
PRC1 encodes a protein that is involved in cytokinesis. The encoded protein is at high level during S and G2/M and drop dramatically after cell exit mitosis and enter G1. It is located in the nucleus during interphase, and becomes associated with mitotic spindles in a highly dynamic manner during mitosis, and localizes to the cell mid-body during cytokinesis. This protein has been shown to be a substrate of several cyclin-dependent kinases (CDKs). PRC1 was a good substrate for several cyclin-dependent kinases (CDK) in vitro and was phosphorylated in vivo at sites that were phosphorylated by CDK in vitro, suggesting that PRC1 is an in vivo CDK substrate. Microinjection of anti-PRC1 antibodies into HeLa cells blocked cellular cleavage, but not nuclear division, indicating a functional role for PRC1 in cytokinesis.

Organism species: Homo sapiens (Human)

CATALOG NO. PRODUCT NAME APPLICATIONS
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Antibodies n/a Monoclonal Antibody to Protein Regulator Of Cytokinesis 1 (PRC1) Monoclonal Antibody Customized Service Offer
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Organism species: Mus musculus (Mouse)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins n/a Recombinant Protein Regulator Of Cytokinesis 1 (PRC1) Recombinant Protein Customized Service Offer
Antibodies n/a Monoclonal Antibody to Protein Regulator Of Cytokinesis 1 (PRC1) Monoclonal Antibody Customized Service Offer
n/a Polyclonal Antibody to Protein Regulator Of Cytokinesis 1 (PRC1) Polyclonal Antibody Customized Service Offer
Assay Kits n/a CLIA Kit for Protein Regulator Of Cytokinesis 1 (PRC1) CLIA Kit Customized Service Offer
n/a ELISA Kit for Protein Regulator Of Cytokinesis 1 (PRC1) ELISA Kit Customized Service Offer

Organism species: Rattus norvegicus (Rat)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins n/a Recombinant Protein Regulator Of Cytokinesis 1 (PRC1) Recombinant Protein Customized Service Offer
Antibodies n/a Monoclonal Antibody to Protein Regulator Of Cytokinesis 1 (PRC1) Monoclonal Antibody Customized Service Offer
n/a Polyclonal Antibody to Protein Regulator Of Cytokinesis 1 (PRC1) Polyclonal Antibody Customized Service Offer
Assay Kits n/a CLIA Kit for Protein Regulator Of Cytokinesis 1 (PRC1) CLIA Kit Customized Service Offer
n/a ELISA Kit for Protein Regulator Of Cytokinesis 1 (PRC1) ELISA Kit Customized Service Offer
  1. "PRC1: a human mitotic spindle-associated CDK substrate protein required for cytokinesis."Mol. Cell 2:877-885(1998) [PubMed] [Europe PMC] [Abstract]
  2. "Complete sequencing and characterization of 21,243 full-length human cDNAs." Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract]
  3. "Analysis of the DNA sequence and duplication history of human chromosome 15." Nature 440:671-675(2006) [PubMed] [Europe PMC] [Abstract]
  4. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract] and Placenta.
  5. "The full-ORF clone resource of the German cDNA consortium."BMC Genomics 8:399-399(2007) [PubMed] [Europe PMC] [Abstract]
  6. "PRC1 is a microtubule binding and bundling protein essential to maintain the mitotic spindle midzone."J. Cell Biol. 157:1175-1186(2002) [PubMed] [Europe PMC] [Abstract]
  7. "Essential roles of KIF4 and its binding partner PRC1 in organized central spindle midzone formation."EMBO J. 23:3237-3248(2004) [PubMed] [Europe PMC] [Abstract]
  8. "Human mitotic spindle-associated protein PRC1 inhibits MgcRacGAP activity toward Cdc42 during the metaphase."J. Biol. Chem. 279:16394-16402(2004) [PubMed] [Europe PMC] [Abstract]
  9. "Cell cycle-dependent translocation of PRC1 on the spindle by Kif4 is essential for midzone formation and cytokinesis."Proc. Natl. Acad. Sci. U.S.A. 102:343-348(2005) [PubMed] [Europe PMC] [Abstract]
  10. "KIF14 and citron kinase act together to promote efficient cytokinesis."J. Cell Biol. 172:363-372(2006) [PubMed] [Europe PMC] [Abstract]
  11. "Mitotic phosphorylation of PRC1 at Thr470 is required for PRC1 oligomerization and proper central spindle organization."Cell Res. 17:449-457(2007) [PubMed] [Europe PMC] [Abstract]
  12. "Choice of Plk1 docking partners during mitosis and cytokinesis is controlled by the activation state of Cdk1."Nat. Cell Biol. 9:436-444(2007) [PubMed] [Europe PMC] [Abstract]
  13. "Kinase-selective enrichment enables quantitative phosphoproteomics of the kinome across the cell cycle."Mol. Cell 31:438-448(2008) [PubMed] [Europe PMC] [Abstract]
  14. "A quantitative atlas of mitotic phosphorylation."Proc. Natl. Acad. Sci. U.S.A. 105:10762-10767(2008) [PubMed] [Europe PMC] [Abstract]
  15. "Large-scale proteomics analysis of the human kinome."Mol. Cell. Proteomics 8:1751-1764(2009) [PubMed] [Europe PMC] [Abstract]
  16. "Polo-like kinase 1 directs assembly of the HsCyk-4 RhoGAP/Ect2 RhoGEF complex to initiate cleavage furrow formation."PLoS Biol. 7:E1000110-E1000110(2009) [PubMed] [Europe PMC] [Abstract]
  17. "Quantitative phosphoproteomics reveals widespread full phosphorylation site occupancy during mitosis."Sci. Signal. 3:RA3-RA3(2010) [PubMed] [Europe PMC] [Abstract]
  18. "Initial characterization of the human central proteome."BMC Syst. Biol. 5:17-17(2011) [PubMed] [Europe PMC] [Abstract]
  19. "N-terminal acetylome analyses and functional insights of the N-terminal acetyltransferase NatB."Proc. Natl. Acad. Sci. U.S.A. 109:12449-12454(2012) [PubMed] [Europe PMC] [Abstract]
  20. "Insights into antiparallel microtubule crosslinking by PRC1, a conserved nonmotor microtubule binding protein."Cell 142:433-443(2010) [PubMed] [Europe PMC] [Abstract]