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Protein Phosphatase Methylesterase 1 (PPME1)

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PME-1

Protein Phosphatase Methylesterase 1 (PPME1)
CCC H325
HGNC 30178
MGI 1919840
PubMed 23911878
RGD 1309683
UniProt Q9Y570
Protein phosphatase methylesterase-1 catalyzes the demethylation of the protein phosphatase-2A catalytic subunit (PPP2CA).
The deduced 386-amino acid protein shares 40% and 26% sequence identity with the C. elegans and S. cerevisiae homologs, respectively. Human PPME1 contains a highly charged stretch of amino acids, and all 3 PPME1 homologs contain a consensus sequence for lipases that use an active site serine.PPME1 forms a stable complex with the catalytically inactive mutant subunits but not with the wildtype subunit. Expression of PPME1 in bacteria demonstrated that PPME1 has PPP2CA methylesterase activity that is inhibited by the PPP2CA inhibitor okadaic acid but not by the serine protease inhibitor PMSF.

Organism species: Homo sapiens (Human)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins n/a Recombinant Protein Phosphatase Methylesterase 1 (PPME1) Recombinant Protein Customized Service Offer
Antibodies n/a Monoclonal Antibody to Protein Phosphatase Methylesterase 1 (PPME1) Monoclonal Antibody Customized Service Offer
n/a Polyclonal Antibody to Protein Phosphatase Methylesterase 1 (PPME1) Polyclonal Antibody Customized Service Offer
Assay Kits n/a CLIA Kit for Protein Phosphatase Methylesterase 1 (PPME1) CLIA Kit Customized Service Offer
n/a ELISA Kit for Protein Phosphatase Methylesterase 1 (PPME1) ELISA Kit Customized Service Offer

Organism species: Mus musculus (Mouse)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins n/a Recombinant Protein Phosphatase Methylesterase 1 (PPME1) Recombinant Protein Customized Service Offer
Antibodies n/a Monoclonal Antibody to Protein Phosphatase Methylesterase 1 (PPME1) Monoclonal Antibody Customized Service Offer
n/a Polyclonal Antibody to Protein Phosphatase Methylesterase 1 (PPME1) Polyclonal Antibody Customized Service Offer
Assay Kits n/a CLIA Kit for Protein Phosphatase Methylesterase 1 (PPME1) CLIA Kit Customized Service Offer
n/a ELISA Kit for Protein Phosphatase Methylesterase 1 (PPME1) ELISA Kit Customized Service Offer

Organism species: Rattus norvegicus (Rat)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins n/a Recombinant Protein Phosphatase Methylesterase 1 (PPME1) Recombinant Protein Customized Service Offer
Antibodies n/a Monoclonal Antibody to Protein Phosphatase Methylesterase 1 (PPME1) Monoclonal Antibody Customized Service Offer
n/a Polyclonal Antibody to Protein Phosphatase Methylesterase 1 (PPME1) Polyclonal Antibody Customized Service Offer
Assay Kits n/a CLIA Kit for Protein Phosphatase Methylesterase 1 (PPME1) CLIA Kit Customized Service Offer
n/a ELISA Kit for Protein Phosphatase Methylesterase 1 (PPME1) ELISA Kit Customized Service Offer
  1. "A protein phosphatase methylesterase (PME-1) is one of several novel proteins stably associating with two inactive mutants of protein phosphatase 2A."J. Biol. Chem. 274:14382-14391(1999) [PubMed] [Europe PMC] [Abstract]
  2. "Complete sequencing and characterization of 21,243 full-length human cDNAs." Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract]
  3. "Human chromosome 11 DNA sequence and analysis including novel gene identification." Nature 440:497-500(2006) [PubMed] [Europe PMC] [Abstract]
  4. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
  5. "Exploring proteomes and analyzing protein processing by mass spectrometric identification of sorted N-terminal peptides."Nat. Biotechnol. 21:566-569(2003) [PubMed] [Europe PMC] [Abstract]
  6. "Large-scale cDNA transfection screening for genes related to cancer development and progression." Proc. Natl. Acad. Sci. U.S.A. 101:15724-15729(2004) [PubMed] [Europe PMC] [Abstract]
  7. "A quantitative atlas of mitotic phosphorylation."Proc. Natl. Acad. Sci. U.S.A. 105:10762-10767(2008) [PubMed] [Europe PMC] [Abstract]
  8. "Quantitative phosphoproteomic analysis of T cell receptor signaling reveals system-wide modulation of protein-protein interactions."Sci. Signal. 2:RA46-RA46(2009) [PubMed] [Europe PMC] [Abstract]
  9. "Quantitative phosphoproteomics reveals widespread full phosphorylation site occupancy during mitosis."Sci. Signal. 3:RA3-RA3(2010) [PubMed] [Europe PMC] [Abstract]
  10. "Initial characterization of the human central proteome."BMC Syst. Biol. 5:17-17(2011) [PubMed] [Europe PMC] [Abstract]
  11. "System-wide temporal characterization of the proteome and phosphoproteome of human embryonic stem cell differentiation."Sci. Signal. 4:RS3-RS3(2011) [PubMed] [Europe PMC] [Abstract]
  12. "An enzyme assisted RP-RPLC approach for in-depth analysis of human liver phosphoproteome."J. Proteomics 96:253-262(2014) [PubMed] [Europe PMC] [Abstract]
  13. "Structural mechanism of demethylation and inactivation of protein phosphatase 2A."Cell 133:154-163(2008) [PubMed] [Europe PMC] [Abstract]