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Protein Phosphatase, Mg2+/Mn2+ Dependent 1A (PPM1A)

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PP2C-ALPHA; PP2CA; Phosphatase 2C Alpha; Protein Phosphatase 1A(Formerly 2C)Magnesium-Dependent,Alpha

Protein Phosphatase, Mg2+/Mn2+ Dependent 1A (PPM1A)
CCC H326
HGNC 9275
MGI 99878
PubMed 16751101
RGD 3373
UniProt P35813
Wiki PPM1A
PPM1A is a member of the PP2C family of Ser/Thr protein phosphatases. PP2C family members are known to be negative regulators of cell stress response pathways. This phosphatase dephosphorylates, and negatively regulates the activities of, MAP kinases and MAP kinase kinases. It has been shown to inhibit the activation of p38 and JNK kinase cascades induced by environmental stresses. This phosphatase can also dephosphorylate cyclin-dependent kinases, and thus may be involved in cell cycle control. Overexpression of this phosphatase is reported to activate the expression of the tumor suppressor gene TP53/p53, which leads to G2/M cell cycle arrest and apoptosis. Three alternatively spliced transcript variants encoding two distinct isoforms have been described.

Organism species: Homo sapiens (Human)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins RPH326Hu01 Recombinant Protein Phosphatase, Mg2+/Mn2+ Dependent 1A (PPM1A) Positive Control; Immunogen; SDS-PAGE; WB.
Antibodies MAH326Hu21 Monoclonal Antibody to Protein Phosphatase, Mg2+/Mn2+ Dependent 1A (PPM1A) WB; IHC; ICC; IP.
PAH326Hu01 Polyclonal Antibody to Protein Phosphatase, Mg2+/Mn2+ Dependent 1A (PPM1A) WB; IHC; ICC; IP.
Assay Kits SEH326Hu ELISA Kit for Protein Phosphatase, Mg2+/Mn2+ Dependent 1A (PPM1A) Enzyme-linked immunosorbent assay for Antigen Detection.

Organism species: Mus musculus (Mouse)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins n/a Recombinant Protein Phosphatase, Mg2+/Mn2+ Dependent 1A (PPM1A) Recombinant Protein Customized Service Offer
Antibodies n/a Monoclonal Antibody to Protein Phosphatase, Mg2+/Mn2+ Dependent 1A (PPM1A) Monoclonal Antibody Customized Service Offer
n/a Polyclonal Antibody to Protein Phosphatase, Mg2+/Mn2+ Dependent 1A (PPM1A) Polyclonal Antibody Customized Service Offer
Assay Kits n/a CLIA Kit for Protein Phosphatase, Mg2+/Mn2+ Dependent 1A (PPM1A) CLIA Kit Customized Service Offer
n/a ELISA Kit for Protein Phosphatase, Mg2+/Mn2+ Dependent 1A (PPM1A) ELISA Kit Customized Service Offer

Organism species: Rattus norvegicus (Rat)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins RPH326Ra01 Recombinant Protein Phosphatase, Mg2+/Mn2+ Dependent 1A (PPM1A) Positive Control; Immunogen; SDS-PAGE; WB.
Antibodies MAH326Ra21 Monoclonal Antibody to Protein Phosphatase, Mg2+/Mn2+ Dependent 1A (PPM1A) WB; IHC; ICC; IP.
PAH326Ra01 Polyclonal Antibody to Protein Phosphatase, Mg2+/Mn2+ Dependent 1A (PPM1A) WB; IHC; ICC; IP.
Assay Kits SEH326Ra ELISA Kit for Protein Phosphatase, Mg2+/Mn2+ Dependent 1A (PPM1A) Enzyme-linked immunosorbent assay for Antigen Detection.
  1. "Mammalian protein serine/threonine phosphatase 2C: cDNA cloning and comparative analysis of amino acid sequences."Biochim. Biophys. Acta 1130:100-104(1992) [PubMed] [Europe PMC] [Abstract]
  2. "Protein phosphatase 2Calpha inhibits the human stress-responsive p38 and JNK MAPK pathways."EMBO J. 17:4744-4752(1998) [PubMed] [Europe PMC] [Abstract]
  3. "Complete sequencing and characterization of 21,243 full-length human cDNAs." Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract]
  4. "Human protein factory for converting the transcriptome into an in vitro-expressed proteome." Nat. Methods 5:1011-1017(2008) [PubMed] [Europe PMC] [Abstract]
  5. "The DNA sequence and analysis of human chromosome 14." Nature 421:601-607(2003) [PubMed] [Europe PMC] [Abstract]
  6. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
  7. "PPM1A functions as a Smad phosphatase to terminate TGFbeta signaling."Cell 125:915-928(2006) [PubMed] [Europe PMC] [Abstract]
  8. "PPM1A and PPM1B act as IKKbeta phosphatases to terminate TNFalpha-induced IKKbeta-NF-kappaB activation."Cell. Signal. 21:95-102(2009) [PubMed] [Europe PMC] [Abstract]
  9. "Quantitative phosphoproteomic analysis of T cell receptor signaling reveals system-wide modulation of protein-protein interactions."Sci. Signal. 2:RA46-RA46(2009) [PubMed] [Europe PMC] [Abstract]
  10. "Strategy for comprehensive identification of human N-myristoylated proteins using an insect cell-free protein synthesis system."Proteomics 10:1780-1793(2010) [PubMed] [Europe PMC] [Abstract]
  11. "Initial characterization of the human central proteome."BMC Syst. Biol. 5:17-17(2011) [PubMed] [Europe PMC] [Abstract]
  12. "Protein phosphatase 5 modulates SMAD3 function in the transforming growth factor-? pathway."Cell. Signal. 24:1999-2006(2012) [PubMed] [Europe PMC] [Abstract]
  13. "An enzyme assisted RP-RPLC approach for in-depth analysis of human liver phosphoproteome."J. Proteomics 96:253-262(2014) [PubMed] [Europe PMC] [Abstract]
  14. "Crystal structure of the protein serine/threonine phosphatase 2C at 2.0-A resolution."EMBO J. 15:6798-6809(1996) [PubMed] [Europe PMC] [Abstract]