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Protein Phosphatase, Mg2+/Mn2+ Dependent 1G (PPM1G)

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PP2CGAMMA; PPP2CG; Protein Phosphatase 2C,Gamma Isoform; Protein Phosphatase 1G(Formerly 2C)Magnesium-Dependent,Gamma

Protein Phosphatase, Mg2+/Mn2+ Dependent 1G (PPM1G)
CCC H329
HGNC 9278
MGI 106065
PubMed 22361354
RGD 628676
UniProt O15355
Wiki PPM1G
PPM1G is a member of the PP2C family of Ser/Thr protein phosphatases. PP2C family members are known to be negative regulators of cell stress response pathways. This phosphatase is found to be responsible for the dephosphorylation of Pre-mRNA splicing factors, which is important for the formation of functional spliceosome.
The deduced 546-amino acid PPM1G protein contains the highly conserved signature sequences of PP2C phosphatases, suggesting that it is a member of the PP2C family. However, PPM1G shares only 34% amino acid sequence identity with human PP2C-alpha. A distinctive feature of PPM1G is the presence of a large acidic domain. PPM1G also contains putative PEST sequences, numerous potential sites for phosphorylation, and a possible myristylation site.

Organism species: Homo sapiens (Human)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins n/a Recombinant Protein Phosphatase, Mg2+/Mn2+ Dependent 1G (PPM1G) Recombinant Protein Customized Service Offer
Antibodies n/a Monoclonal Antibody to Protein Phosphatase, Mg2+/Mn2+ Dependent 1G (PPM1G) Monoclonal Antibody Customized Service Offer
n/a Polyclonal Antibody to Protein Phosphatase, Mg2+/Mn2+ Dependent 1G (PPM1G) Polyclonal Antibody Customized Service Offer
Assay Kits n/a CLIA Kit for Protein Phosphatase, Mg2+/Mn2+ Dependent 1G (PPM1G) CLIA Kit Customized Service Offer
n/a ELISA Kit for Protein Phosphatase, Mg2+/Mn2+ Dependent 1G (PPM1G) ELISA Kit Customized Service Offer

Organism species: Mus musculus (Mouse)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins n/a Recombinant Protein Phosphatase, Mg2+/Mn2+ Dependent 1G (PPM1G) Recombinant Protein Customized Service Offer
Antibodies n/a Monoclonal Antibody to Protein Phosphatase, Mg2+/Mn2+ Dependent 1G (PPM1G) Monoclonal Antibody Customized Service Offer
n/a Polyclonal Antibody to Protein Phosphatase, Mg2+/Mn2+ Dependent 1G (PPM1G) Polyclonal Antibody Customized Service Offer
Assay Kits n/a CLIA Kit for Protein Phosphatase, Mg2+/Mn2+ Dependent 1G (PPM1G) CLIA Kit Customized Service Offer
n/a ELISA Kit for Protein Phosphatase, Mg2+/Mn2+ Dependent 1G (PPM1G) ELISA Kit Customized Service Offer

Organism species: Rattus norvegicus (Rat)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins n/a Recombinant Protein Phosphatase, Mg2+/Mn2+ Dependent 1G (PPM1G) Recombinant Protein Customized Service Offer
Antibodies n/a Monoclonal Antibody to Protein Phosphatase, Mg2+/Mn2+ Dependent 1G (PPM1G) Monoclonal Antibody Customized Service Offer
n/a Polyclonal Antibody to Protein Phosphatase, Mg2+/Mn2+ Dependent 1G (PPM1G) Polyclonal Antibody Customized Service Offer
Assay Kits n/a CLIA Kit for Protein Phosphatase, Mg2+/Mn2+ Dependent 1G (PPM1G) CLIA Kit Customized Service Offer
n/a ELISA Kit for Protein Phosphatase, Mg2+/Mn2+ Dependent 1G (PPM1G) ELISA Kit Customized Service Offer
  1. "PP2C gamma: a human protein phosphatase with a unique acidic domain."FEBS Lett. 412:415-419(1997) [PubMed] [Europe PMC] [Abstract]
  2. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
  3. "ATM and ATR substrate analysis reveals extensive protein networks responsive to DNA damage."Science 316:1160-1166(2007) [PubMed] [Europe PMC] [Abstract]
  4. "A quantitative atlas of mitotic phosphorylation."Proc. Natl. Acad. Sci. U.S.A. 105:10762-10767(2008) [PubMed] [Europe PMC] [Abstract]
  5. "Quantitative phosphoproteomic analysis of T cell receptor signaling reveals system-wide modulation of protein-protein interactions."Sci. Signal. 2:RA46-RA46(2009) [PubMed] [Europe PMC] [Abstract]
  6. "Lysine acetylation targets protein complexes and co-regulates major cellular functions."Science 325:834-840(2009) [PubMed] [Europe PMC] [Abstract]
  7. "Quantitative phosphoproteomics reveals widespread full phosphorylation site occupancy during mitosis."Sci. Signal. 3:RA3-RA3(2010) [PubMed] [Europe PMC] [Abstract]
  8. "Initial characterization of the human central proteome."BMC Syst. Biol. 5:17-17(2011) [PubMed] [Europe PMC] [Abstract]
  9. "System-wide temporal characterization of the proteome and phosphoproteome of human embryonic stem cell differentiation."Sci. Signal. 4:RS3-RS3(2011) [PubMed] [Europe PMC] [Abstract]
  10. "An enzyme assisted RP-RPLC approach for in-depth analysis of human liver phosphoproteome."J. Proteomics 96:253-262(2014) [PubMed] [Europe PMC] [Abstract]