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Protein Phosphatase, Mg2+/Mn2+ Dependent 1K (PPM1K)

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PTMP; PP2Ckappa; hPTMP; PP2Cm; PP2C-Type Mitochondrial Phosphoprotein Phosphatase; Protein Phosphatase 2C Kappa

Protein Phosphatase, Mg2+/Mn2+ Dependent 1K (PPM1K)
CCC H331
HGNC 25415
MGI 2442111
PubMed 23086801
RGD 1308501
UniProt Q8N3J5
Wiki PPM1K
PPM1K exhibited phosphatase activity against a synthetic substrate in the presence of Mn(2+), but not Mg(2+). It showed phosphoserine phosphatase activity against the branched-chain alpha-keto acid dehydrogenase complex, suggesting it may play a role in regulating branched-chain amino acid catabolism.The deduced 372-amino acid protein contains an N-terminal mitochondrial localization signal and a central PP2C catalytic domain. Northern blot analysis of mouse tissues detected highest expression of Pp2cm in adult heart, brain, and diaphragm, with lower levels in liver, lung, kidney, skeletal muscle, and thymus. Immunohistochemical analysis of neonatal rat cardiomyocytes revealed colocalization of Pp2cm with a mitochondrial marker.

Organism species: Homo sapiens (Human)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins n/a Recombinant Protein Phosphatase, Mg2+/Mn2+ Dependent 1K (PPM1K) Recombinant Protein Customized Service Offer
Antibodies n/a Monoclonal Antibody to Protein Phosphatase, Mg2+/Mn2+ Dependent 1K (PPM1K) Monoclonal Antibody Customized Service Offer
n/a Polyclonal Antibody to Protein Phosphatase, Mg2+/Mn2+ Dependent 1K (PPM1K) Polyclonal Antibody Customized Service Offer
Assay Kits n/a CLIA Kit for Protein Phosphatase, Mg2+/Mn2+ Dependent 1K (PPM1K) CLIA Kit Customized Service Offer
n/a ELISA Kit for Protein Phosphatase, Mg2+/Mn2+ Dependent 1K (PPM1K) ELISA Kit Customized Service Offer

Organism species: Mus musculus (Mouse)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins n/a Recombinant Protein Phosphatase, Mg2+/Mn2+ Dependent 1K (PPM1K) Recombinant Protein Customized Service Offer
Antibodies n/a Monoclonal Antibody to Protein Phosphatase, Mg2+/Mn2+ Dependent 1K (PPM1K) Monoclonal Antibody Customized Service Offer
n/a Polyclonal Antibody to Protein Phosphatase, Mg2+/Mn2+ Dependent 1K (PPM1K) Polyclonal Antibody Customized Service Offer
Assay Kits n/a CLIA Kit for Protein Phosphatase, Mg2+/Mn2+ Dependent 1K (PPM1K) CLIA Kit Customized Service Offer
n/a ELISA Kit for Protein Phosphatase, Mg2+/Mn2+ Dependent 1K (PPM1K) ELISA Kit Customized Service Offer

Organism species: Rattus norvegicus (Rat)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins n/a Recombinant Protein Phosphatase, Mg2+/Mn2+ Dependent 1K (PPM1K) Recombinant Protein Customized Service Offer
Antibodies n/a Monoclonal Antibody to Protein Phosphatase, Mg2+/Mn2+ Dependent 1K (PPM1K) Monoclonal Antibody Customized Service Offer
n/a Polyclonal Antibody to Protein Phosphatase, Mg2+/Mn2+ Dependent 1K (PPM1K) Polyclonal Antibody Customized Service Offer
Assay Kits n/a CLIA Kit for Protein Phosphatase, Mg2+/Mn2+ Dependent 1K (PPM1K) CLIA Kit Customized Service Offer
n/a ELISA Kit for Protein Phosphatase, Mg2+/Mn2+ Dependent 1K (PPM1K) ELISA Kit Customized Service Offer
  1. "A novel mitochondrial matrix serine/threonine protein phosphatase regulates the mitochondria permeability transition pore and is essential for cellular survival and development."Genes Dev. 21:784-796(2007) [PubMed] [Europe PMC] [Abstract]
  2. "Identification of a novel PP2C-type mitochondrial phosphatase."Biochem. Biophys. Res. Commun. 356:38-44(2007) [PubMed] [Europe PMC] [Abstract]
  3. "Complete sequencing and characterization of 21,243 full-length human cDNAs." Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract]
  4. "The full-ORF clone resource of the German cDNA consortium."BMC Genomics 8:399-399(2007) [PubMed] [Europe PMC] [Abstract]
  5. "Generation and annotation of the DNA sequences of human chromosomes 2 and 4." Nature 434:724-731(2005) [PubMed] [Europe PMC] [Abstract]
  6. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
  7. "A novel regulatory defect in the branched-chain alpha-keto acid dehydrogenase complex due to a mutation in the PPM1K gene causes a mild variant phenotype of maple syrup urine disease."Hum. Mutat. 34:355-362(2013) [PubMed] [Europe PMC] [Abstract]
  8. "Structural genomics of protein phosphatases." J. Struct. Funct. Genomics 8:121-140(2007) [PubMed] [Europe PMC] [Abstract]
  9. "Mutations in ANO3 cause dominant craniocervical dystonia: ion channel implicated in pathogenesis."Am. J. Hum. Genet. 91:1041-1050(2012) [PubMed] [Europe PMC] [Abstract]