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Plexin B1 (PLXNB1)

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PLXN5; SEP; Semaphorin receptor SEP

Plexin B1 (PLXNB1)
CCC H358
HGNC 9103
MGI 2154238
PubMed 22019888
RGD 1310564
UniProt O43157
Wiki PLXNB1
The cDNA sequence (FB7) was isolated by serendipity from a human fetal brain cDNA library. The SEP gene was expressed at highest levels in fetal kidney.
PLXNB1 is a receptor for the transmembrane semaphorin SEMA4D, also called CD100. Binding of SEMA4D to PLXNB1 stimulated tyrosine kinase activity of MET, resulting in tyrosine phosphorylation of both receptors. This effect was not found in cells lacking MET expression.This activity required the interaction of plexin B1 with RND1 , a small GTP-binding protein of the Rho family. Downregulation of RRAS activity by the plexin B1/RND1 complex was essential for the SEMA4D-induced growth cone collapse in hippocampal neurons.

Organism species: Homo sapiens (Human)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins RPH358Hu01 Recombinant Plexin B1 (PLXNB1) Positive Control; Immunogen; SDS-PAGE; WB.
RPH358Hu02 Recombinant Plexin B1 (PLXNB1) Positive Control; Immunogen; SDS-PAGE; WB.
RPH358Hu03 Recombinant Plexin B1 (PLXNB1) Positive Control; Immunogen; SDS-PAGE; WB.
RPH358Hu04 Recombinant Plexin B1 (PLXNB1) Positive Control; Immunogen; SDS-PAGE; WB.
Antibodies PAH358Hu01 Polyclonal Antibody to Plexin B1 (PLXNB1) WB
PAH358Hu02 Polyclonal Antibody to Plexin B1 (PLXNB1) WB; IHC; ICC; IP.
PAH358Hu03 Polyclonal Antibody to Plexin B1 (PLXNB1) WB; IHC; ICC; IP.
Assay Kits SEH358Hu ELISA Kit for Plexin B1 (PLXNB1) Enzyme-linked immunosorbent assay for Antigen Detection.

Organism species: Mus musculus (Mouse)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins RPH358Mu01 Recombinant Plexin B1 (PLXNB1) Positive Control; Immunogen; SDS-PAGE; WB.
Antibodies PAH358Mu01 Polyclonal Antibody to Plexin B1 (PLXNB1) WB; IHC; ICC; IP.
Assay Kits n/a CLIA Kit for Plexin B1 (PLXNB1) CLIA Kit Customized Service Offer
n/a ELISA Kit for Plexin B1 (PLXNB1) ELISA Kit Customized Service Offer

Organism species: Rattus norvegicus (Rat)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins n/a Recombinant Plexin B1 (PLXNB1) Recombinant Protein Customized Service Offer
Antibodies n/a Monoclonal Antibody to Plexin B1 (PLXNB1) Monoclonal Antibody Customized Service Offer
n/a Polyclonal Antibody to Plexin B1 (PLXNB1) Polyclonal Antibody Customized Service Offer
Assay Kits n/a CLIA Kit for Plexin B1 (PLXNB1) CLIA Kit Customized Service Offer
n/a ELISA Kit for Plexin B1 (PLXNB1) ELISA Kit Customized Service Offer
  1. "Prediction of the coding sequences of unidentified human genes. VIII. 78 new cDNA clones from brain which code for large proteins in vitro."DNA Res. 4:307-313(1997) [PubMed] [Europe PMC] [Abstract]
  2. "Plexins are a large family of receptors for transmembrane, secreted and GPI-anchored semaphorins in vertebrates."Cell 99:71-80(1999) [PubMed] [Europe PMC] [Abstract]
  3. ErratumCell 104:321-321(2001)
  4. "A family of transmembrane proteins with homology to the MET-hepatocyte growth factor receptor."Proc. Natl. Acad. Sci. U.S.A. 93:674-678(1996) [PubMed] [Europe PMC] [Abstract]
  5. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
  6. "The semaphorin receptor plexin-B1 specifically interacts with active Rac in a ligand-dependent manner."Proc. Natl. Acad. Sci. U.S.A. 97:12457-12462(2000) [PubMed] [Europe PMC] [Abstract]
  7. "The semaphorin 4D receptor controls invasive growth by coupling with Met."Nat. Cell Biol. 4:720-724(2002) [PubMed] [Europe PMC] [Abstract]
  8. "The semaphorin receptor plexin-B1 signals through a direct interaction with the Rho-specific nucleotide exchange factor, LARG."Proc. Natl. Acad. Sci. U.S.A. 99:12085-12090(2002) [PubMed] [Europe PMC] [Abstract]
  9. "Functional regulation of semaphorin receptors by proprotein convertases."J. Biol. Chem. 278:10094-10101(2003) [PubMed] [Europe PMC] [Abstract]
  10. "Direct interaction of Rnd1 with Plexin-B1 regulates PDZ-RhoGEF-mediated Rho activation by Plexin-B1 and induces cell contraction in COS-7 cells."J. Biol. Chem. 278:25671-25677(2003) [PubMed] [Europe PMC] [Abstract]
  11. "Plexin-B1/RhoGEF-mediated RhoA activation involves the receptor tyrosine kinase ErbB-2."J. Cell Biol. 165:869-880(2004) [PubMed] [Europe PMC] [Abstract]
  12. "Interplay between scatter factor receptors and B plexins controls invasive growth."Oncogene 23:5131-5137(2004) [PubMed] [Europe PMC] [Abstract]
  13. "Human plasma N-glycoproteome analysis by immunoaffinity subtraction, hydrazide chemistry, and mass spectrometry."J. Proteome Res. 4:2070-2080(2005) [PubMed] [Europe PMC] [Abstract]
  14. "Glycoproteomics analysis of human liver tissue by combination of multiple enzyme digestion and hydrazide chemistry."J. Proteome Res. 8:651-661(2009) [PubMed] [Europe PMC] [Abstract]
  15. "Mass-spectrometric identification and relative quantification of N-linked cell surface glycoproteins."Nat. Biotechnol. 27:378-386(2009) [PubMed] [Europe PMC] [Abstract]
  16. "An enzyme assisted RP-RPLC approach for in-depth analysis of human liver phosphoproteome."J. Proteomics 96:253-262(2014) [PubMed] [Europe PMC] [Abstract]
  17. "Binding of Rac1, Rnd1, and RhoD to a novel Rho GTPase interaction motif destabilizes dimerization of the plexin-B1 effector domain."J. Biol. Chem. 282:37215-37224(2007) [PubMed] [Europe PMC] [Abstract]
  18. "Conformational change upon ligand binding and dynamics of the PDZ domain from leukemia-associated Rho guanine nucleotide exchange factor."Protein Sci. 17:1003-1014(2008) [PubMed] [Europe PMC] [Abstract]
  19. "Insights into oncogenic mutations of plexin-B1 based on the solution structure of the Rho GTPase binding domain."Structure 16:246-258(2008) [PubMed] [Europe PMC] [Abstract]
  20. "Structure and function of the intracellular region of the plexin-B1 transmembrane receptor."J. Biol. Chem. 284:35962-35972(2009) [PubMed] [Europe PMC] [Abstract]
  21. "Structural basis of semaphorin-plexin signalling."Nature 467:1118-1122(2010) [PubMed] [Europe PMC] [Abstract]
  22. "A dual binding mode for RhoGTPases in plexin signalling."PLoS Biol. 9:E1001134-E1001134(2011) [PubMed] [Europe PMC] [Abstract]
  23. "The consensus coding sequences of human breast and colorectal cancers." Science 314:268-274(2006) [PubMed] [Europe PMC] [Abstract]