Plexin C1 (PLXNC1)

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CD232; VESPR; Virus-Encoded Semaphorin Protein Receptor

Plexin C1 (PLXNC1)
Tandem mass spectrometry of receptor peptides yielded partial amino acid sequences that allowed the identification of cDNA clones corresponding to the A39R receptor, called VESPR, The VESPR protein contains 1,568 amino acids and has a molecular mass of approximately 200 kD. Sequence analysis indicated that VESPR is a transmembrane glycoprotein and a member of the plexin family. Additional sequence analysis identified a semaphorin-like domain within this family, suggesting an evolutionary relationship between receptor and ligand. VESPR transcript in brain, lung, spleen, and placenta, and an approximately 7.5-kb VESPR transcript in heart. A39R upregulated ICAM1 on, and induced cytokine production from, human monocytes, suggesting that this viral protein can function as an immune modulator during virus infection.

Organism species: Homo sapiens (Human)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins n/a Recombinant Plexin C1 (PLXNC1) Recombinant Protein Customized Service Offer
Antibodies n/a Monoclonal Antibody to Plexin C1 (PLXNC1) Monoclonal Antibody Customized Service Offer
n/a Polyclonal Antibody to Plexin C1 (PLXNC1) Polyclonal Antibody Customized Service Offer
Assay Kits n/a CLIA Kit for Plexin C1 (PLXNC1) CLIA Kit Customized Service Offer
n/a ELISA Kit for Plexin C1 (PLXNC1) ELISA Kit Customized Service Offer

Organism species: Mus musculus (Mouse)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins n/a Recombinant Plexin C1 (PLXNC1) Recombinant Protein Customized Service Offer
Antibodies n/a Monoclonal Antibody to Plexin C1 (PLXNC1) Monoclonal Antibody Customized Service Offer
n/a Polyclonal Antibody to Plexin C1 (PLXNC1) Polyclonal Antibody Customized Service Offer
Assay Kits n/a CLIA Kit for Plexin C1 (PLXNC1) CLIA Kit Customized Service Offer
n/a ELISA Kit for Plexin C1 (PLXNC1) ELISA Kit Customized Service Offer

Organism species: Rattus norvegicus (Rat)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins n/a Recombinant Plexin C1 (PLXNC1) Recombinant Protein Customized Service Offer
Antibodies n/a Monoclonal Antibody to Plexin C1 (PLXNC1) Monoclonal Antibody Customized Service Offer
n/a Polyclonal Antibody to Plexin C1 (PLXNC1) Polyclonal Antibody Customized Service Offer
Assay Kits n/a CLIA Kit for Plexin C1 (PLXNC1) CLIA Kit Customized Service Offer
n/a ELISA Kit for Plexin C1 (PLXNC1) ELISA Kit Customized Service Offer
  1. "A poxvirus-encoded semaphorin induces cytokine production from monocytes and binds to a novel cellular semaphorin receptor, VESPR."Immunity 8:473-482(1998) [PubMed] [Europe PMC] [Abstract]
  2. "Crystal structure of the ubiquitin like domain of PLXNC1."Submitted (DEC-2009) to the PDB data bank
  3. "Structural basis of semaphorin-plexin recognition and viral mimicry from Sema7A and A39R complexes with PlexinC1."Cell 142:749-761(2010) [PubMed] [Europe PMC] [Abstract]