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Palate/Lung And Nasal Epithelium Associated Protein (PLUNC)

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BPIFA1; SPURT; NASG; LUNX; SPLUNC1; Secretory Protein In Upper Respiratory Tracts; BPI Fold Containing Family A, Member 1; Nasopharyngeal carcinoma-related

Palate/Lung And Nasal Epithelium Associated Protein (PLUNC)
CCC H364
HGNC 15749
MGI 1338036
PubMed 22676062
RGD 619818
UniProt Q9NP55
Wiki Plunc
PLUNC is the human homolog of murine plunc, and like the mouse gene, is specifically expressed in the upper airways and nasopharyngeal regions. The exact biological function of this gene is not known, however, it has been suggested to be involved in inflammatory responses to irritants in the upper airways. It may also serve as a potential molecular marker for detection of micrometastasis in non-small-cell lung cancer. Multiple transcript variants resulting from alternative splicing in the 3' UTR have been detected, but the full-length nature of only two is known.The cDNA encodes a leucine-rich protein of 256 amino acids that is 72% identical to the murine protein. within the human PLUNC family, amino acid sequence identity is low, ranging from 16 to 28%.

Organism species: Homo sapiens (Human)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins RPH364Hu01 Recombinant Palate/Lung And Nasal Epithelium Associated Protein (PLUNC) Positive Control; Immunogen; SDS-PAGE; WB.
RPH364Hu02 Recombinant Palate/Lung And Nasal Epithelium Associated Protein (PLUNC) Positive Control; Immunogen; SDS-PAGE; WB.
Antibodies MAH364Hu21 Monoclonal Antibody to Palate/Lung And Nasal Epithelium Associated Protein (PLUNC) WB; IHC; ICC; IP.
PAH364Hu01 Polyclonal Antibody to Palate/Lung And Nasal Epithelium Associated Protein (PLUNC) WB; IHC; ICC; IP.
Assay Kits SEH364Hu ELISA Kit for Palate/Lung And Nasal Epithelium Associated Protein (PLUNC) Enzyme-linked immunosorbent assay for Antigen Detection.

Organism species: Mus musculus (Mouse)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins RPH364Mu01 Recombinant Palate/Lung And Nasal Epithelium Associated Protein (PLUNC) Positive Control; Immunogen; SDS-PAGE; WB.
RPH364Mu02 Recombinant Palate/Lung And Nasal Epithelium Associated Protein (PLUNC) Positive Control; Immunogen; SDS-PAGE; WB.
Antibodies PAH364Mu01 Polyclonal Antibody to Palate/Lung And Nasal Epithelium Associated Protein (PLUNC) WB; IHC; ICC; IP.
PAH364Mu02 Polyclonal Antibody to Palate/Lung And Nasal Epithelium Associated Protein (PLUNC) WB; IHC; ICC; IP.
Assay Kits SEH364Mu ELISA Kit for Palate/Lung And Nasal Epithelium Associated Protein (PLUNC) Enzyme-linked immunosorbent assay for Antigen Detection.

Organism species: Rattus norvegicus (Rat)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins n/a Recombinant Palate/Lung And Nasal Epithelium Associated Protein (PLUNC) Recombinant Protein Customized Service Offer
Antibodies n/a Monoclonal Antibody to Palate/Lung And Nasal Epithelium Associated Protein (PLUNC) Monoclonal Antibody Customized Service Offer
n/a Polyclonal Antibody to Palate/Lung And Nasal Epithelium Associated Protein (PLUNC) Polyclonal Antibody Customized Service Offer
Assay Kits n/a CLIA Kit for Palate/Lung And Nasal Epithelium Associated Protein (PLUNC) CLIA Kit Customized Service Offer
n/a ELISA Kit for Palate/Lung And Nasal Epithelium Associated Protein (PLUNC) ELISA Kit Customized Service Offer
  1. "Characterization of the human plunc gene, a gene product with an upper airways and nasopharyngeal restricted expression pattern."Biochim. Biophys. Acta 1493:363-367(2000) [PubMed] [Europe PMC] [Abstract]
  2. "Cloning of a novel gene associated with human nasopharyngeal carcinoma."Chin. Sci. Bull. 45:2267-2272(2000)
  3. "Isolation of a novel human lung-specific gene, LUNX, a potential molecular marker for detection of micrometastasis in non-small-cell lung cancer."Int. J. Cancer 91:433-437(2001) [PubMed] [Europe PMC] [Abstract]
  4. "Molecular cloning and characterization of spurt, a human novel gene that is retinoic acid-inducible and encodes a secretory protein specific in upper respiratory tracts."J. Biol. Chem. 278:1165-1173(2003) [PubMed] [Europe PMC] [Abstract]
  5. "The secreted protein discovery initiative (SPDI), a large-scale effort to identify novel human secreted and transmembrane proteins: a bioinformatics assessment." Genome Res. 13:2265-2270(2003) [PubMed] [Europe PMC] [Abstract]
  6. "Complete sequencing and characterization of 21,243 full-length human cDNAs." Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract]
  7. "The DNA sequence and comparative analysis of human chromosome 20." Nature 414:865-871(2001) [PubMed] [Europe PMC] [Abstract]
  8. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
  9. "Identification of a new potential airway irritation marker, palate lung nasal epithelial clone protein, in human nasal lavage fluid with two-dimensional electrophoresis and matrix-assisted laser desorption/ionization-time of flight."Electrophoresis 22:1795-1800(2001) [PubMed] [Europe PMC] [Abstract]
  10. "PLUNC in human nasal lavage fluid: multiple isoforms that bind to lipopolysaccharide."Biochim. Biophys. Acta 1699:57-63(2004) [PubMed] [Europe PMC] [Abstract]
  11. "Purification and characterization of PLUNC from human tracheobronchial secretions."Am. J. Respir. Cell Mol. Biol. 30:184-192(2004) [PubMed] [Europe PMC] [Abstract]
  12. "SPLUNC1/BPIFA1 contributes to pulmonary host defense against Klebsiella pneumoniae respiratory infection."Am. J. Pathol. 182:1519-1531(2013) [PubMed] [Europe PMC] [Abstract]
  13. "Identification of the SPLUNC1 ENaC-inhibitory domain yields novel strategies to treat sodium hyperabsorption in cystic fibrosis airway epithelial cultures."Am. J. Physiol. 305:L990-L1001(2013) [PubMed] [Europe PMC] [Abstract]
  14. "Multifunctional role of human SPLUNC1 in Pseudomonas aeruginosa infection."Infect. Immun. 81:285-291(2013) [PubMed] [Europe PMC] [Abstract]
  15. "Molecular basis for pH-dependent mucosal dehydration in cystic fibrosis airways."Proc. Natl. Acad. Sci. U.S.A. 110:15973-15978(2013) [PubMed] [Europe PMC] [Abstract]