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PHD Finger Protein 2 (PHF2)

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JHDM1E; CENP-35; GRC5; Lysine-specific demethylase PHF2; Jumonji C Domain-Containing Histone Demethylase 1E

PHD Finger Protein 2 (PHF2)
CCC H372
HGNC 8920
MGI 1338034
PubMed 21532585
RGD 1305228
UniProt O75151
PHF2 encodes a protein which contains a zinc finger-like PHD (plant homeodomain) finger, distinct from other classes of zinc finger motifs, and a hydrophobic and highly conserved domain. The PHD finger shows the typical Cys4-His-Cys3 arrangement. PHD finger genes are thought to belong to a diverse group of transcriptional regulators possibly affecting eukaryotic gene expression by influencing chromatin structure.
The PHF2 cDNA encodes a putative 1,099-amino acid protein with a PHD finger motif at the N terminus, 8 putative nuclear localization signals, and 2 PEST (proline-glutamic acid-serine-threonine) domains. Northern blot analysis of adult human tissues detected a 5.5-kb transcript in all tissues examined.

Organism species: Homo sapiens (Human)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins n/a Recombinant PHD Finger Protein 2 (PHF2) Recombinant Protein Customized Service Offer
Antibodies n/a Monoclonal Antibody to PHD Finger Protein 2 (PHF2) Monoclonal Antibody Customized Service Offer
n/a Polyclonal Antibody to PHD Finger Protein 2 (PHF2) Polyclonal Antibody Customized Service Offer
Assay Kits n/a CLIA Kit for PHD Finger Protein 2 (PHF2) CLIA Kit Customized Service Offer
n/a ELISA Kit for PHD Finger Protein 2 (PHF2) ELISA Kit Customized Service Offer

Organism species: Mus musculus (Mouse)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins n/a Recombinant PHD Finger Protein 2 (PHF2) Recombinant Protein Customized Service Offer
Antibodies n/a Monoclonal Antibody to PHD Finger Protein 2 (PHF2) Monoclonal Antibody Customized Service Offer
n/a Polyclonal Antibody to PHD Finger Protein 2 (PHF2) Polyclonal Antibody Customized Service Offer
Assay Kits n/a CLIA Kit for PHD Finger Protein 2 (PHF2) CLIA Kit Customized Service Offer
n/a ELISA Kit for PHD Finger Protein 2 (PHF2) ELISA Kit Customized Service Offer

Organism species: Rattus norvegicus (Rat)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins n/a Recombinant PHD Finger Protein 2 (PHF2) Recombinant Protein Customized Service Offer
Antibodies n/a Monoclonal Antibody to PHD Finger Protein 2 (PHF2) Monoclonal Antibody Customized Service Offer
n/a Polyclonal Antibody to PHD Finger Protein 2 (PHF2) Polyclonal Antibody Customized Service Offer
Assay Kits n/a CLIA Kit for PHD Finger Protein 2 (PHF2) CLIA Kit Customized Service Offer
n/a ELISA Kit for PHD Finger Protein 2 (PHF2) ELISA Kit Customized Service Offer
  1. "PHF2, a novel PHD finger gene located on human chromosome 9q22."Mamm. Genome 10:294-298(1999) [PubMed] [Europe PMC] [Abstract]
  2. "Prediction of the coding sequences of unidentified human genes. X. The complete sequences of 100 new cDNA clones from brain which can code for large proteins in vitro."DNA Res. 5:169-176(1998) [PubMed] [Europe PMC] [Abstract]
  3. "Construction of expression-ready cDNA clones for KIAA genes: manual curation of 330 KIAA cDNA clones."DNA Res. 9:99-106(2002) [PubMed] [Europe PMC] [Abstract]
  4. "DNA sequence and analysis of human chromosome 9." Nature 429:369-374(2004) [PubMed] [Europe PMC] [Abstract]
  5. "The full-ORF clone resource of the German cDNA consortium."BMC Genomics 8:399-399(2007) [PubMed] [Europe PMC] [Abstract]
  6. "Global, in vivo, and site-specific phosphorylation dynamics in signaling networks."Cell 127:635-648(2006) [PubMed] [Europe PMC] [Abstract]
  7. "A quantitative atlas of mitotic phosphorylation."Proc. Natl. Acad. Sci. U.S.A. 105:10762-10767(2008) [PubMed] [Europe PMC] [Abstract]
  8. "Lys-N and trypsin cover complementary parts of the phosphoproteome in a refined SCX-based approach."Anal. Chem. 81:4493-4501(2009) [PubMed] [Europe PMC] [Abstract]
  9. "Quantitative phosphoproteomic analysis of T cell receptor signaling reveals system-wide modulation of protein-protein interactions."Sci. Signal. 2:RA46-RA46(2009) [PubMed] [Europe PMC] [Abstract]
  10. "The protein composition of mitotic chromosomes determined using multiclassifier combinatorial proteomics."Cell 142:810-821(2010) [PubMed] [Europe PMC] [Abstract]
  11. "Quantitative phosphoproteomics reveals widespread full phosphorylation site occupancy during mitosis."Sci. Signal. 3:RA3-RA3(2010) [PubMed] [Europe PMC] [Abstract]
  12. "PKA-dependent regulation of the histone lysine demethylase complex PHF2-ARID5B."Nat. Cell Biol. 13:668-675(2011) [PubMed] [Europe PMC] [Abstract]
  13. "System-wide temporal characterization of the proteome and phosphoproteome of human embryonic stem cell differentiation."Sci. Signal. 4:RS3-RS3(2011) [PubMed] [Europe PMC] [Abstract]
  14. "An enzyme assisted RP-RPLC approach for in-depth analysis of human liver phosphoproteome."J. Proteomics 96:253-262(2014) [PubMed] [Europe PMC] [Abstract]
  15. "Recognition of histone H3K4 trimethylation by the plant homeodomain of PHF2 modulates histone demethylation."J. Biol. Chem. 285:9322-9326(2010) [PubMed] [Europe PMC] [Abstract]
  16. "Structural basis for human PHF2 Jumonji domain interaction with metal ions."J. Mol. Biol. 406:1-8(2011) [PubMed] [Europe PMC] [Abstract]