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Progesterone Receptor Membrane Component 2 (PGRMC2)

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PMBP; DG6; Progesterone membrane-binding protein; Steroid receptor protein DG6; Membrane-associated progesterone receptor component 2

Progesterone Receptor Membrane Component 2 (PGRMC2)
CCC H376
HGNC 16089
MGI 1918054
RGD 1308804
UniProt O15173
Using the sequence of a porcine progesterone receptor as probe, Gerdes et al. (1998) cloned PGRMC2, which they designated DG6. The deduced protein contains 223 amino acids and has an N-terminal hydrophobic region. It has no N-glycosylation site. PGRMC2 shares about 50% identity overall with PGRMC1, and they share 68% identity in their C termini, including a highly conserved 58-amino acid sequence. Northern blot analysis revealed expression of 2.0-kb transcripts in all tissues examined, with highest expression in placenta.
Transcripts of 3.0 and 5.0 kb were also detected.By genomic sequence analysis, Gerdes et al. (1998) mapped the PGRMC2 gene to chromosome 4q26.

Organism species: Homo sapiens (Human)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins n/a Recombinant Progesterone Receptor Membrane Component 2 (PGRMC2) Recombinant Protein Customized Service Offer
Antibodies n/a Monoclonal Antibody to Progesterone Receptor Membrane Component 2 (PGRMC2) Monoclonal Antibody Customized Service Offer
n/a Polyclonal Antibody to Progesterone Receptor Membrane Component 2 (PGRMC2) Polyclonal Antibody Customized Service Offer
Assay Kits n/a CLIA Kit for Progesterone Receptor Membrane Component 2 (PGRMC2) CLIA Kit Customized Service Offer
n/a ELISA Kit for Progesterone Receptor Membrane Component 2 (PGRMC2) ELISA Kit Customized Service Offer

Organism species: Mus musculus (Mouse)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins n/a Recombinant Progesterone Receptor Membrane Component 2 (PGRMC2) Recombinant Protein Customized Service Offer
Antibodies n/a Monoclonal Antibody to Progesterone Receptor Membrane Component 2 (PGRMC2) Monoclonal Antibody Customized Service Offer
n/a Polyclonal Antibody to Progesterone Receptor Membrane Component 2 (PGRMC2) Polyclonal Antibody Customized Service Offer
Assay Kits n/a CLIA Kit for Progesterone Receptor Membrane Component 2 (PGRMC2) CLIA Kit Customized Service Offer
n/a ELISA Kit for Progesterone Receptor Membrane Component 2 (PGRMC2) ELISA Kit Customized Service Offer

Organism species: Rattus norvegicus (Rat)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins n/a Recombinant Progesterone Receptor Membrane Component 2 (PGRMC2) Recombinant Protein Customized Service Offer
Antibodies n/a Monoclonal Antibody to Progesterone Receptor Membrane Component 2 (PGRMC2) Monoclonal Antibody Customized Service Offer
n/a Polyclonal Antibody to Progesterone Receptor Membrane Component 2 (PGRMC2) Polyclonal Antibody Customized Service Offer
Assay Kits n/a CLIA Kit for Progesterone Receptor Membrane Component 2 (PGRMC2) CLIA Kit Customized Service Offer
n/a ELISA Kit for Progesterone Receptor Membrane Component 2 (PGRMC2) ELISA Kit Customized Service Offer
  1. "Cloning and tissue expression of two putative steroid membrane receptors."Biol. Chem. 379:907-911(1998) [PubMed] [Europe PMC] [Abstract]
  2. "Complete sequencing and characterization of 21,243 full-length human cDNAs." Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract]
  3. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
  4. "Global, in vivo, and site-specific phosphorylation dynamics in signaling networks."Cell 127:635-648(2006) [PubMed] [Europe PMC] [Abstract]
  5. "Kinase-selective enrichment enables quantitative phosphoproteomics of the kinome across the cell cycle."Mol. Cell 31:438-448(2008) [PubMed] [Europe PMC] [Abstract]
  6. "A quantitative atlas of mitotic phosphorylation."Proc. Natl. Acad. Sci. U.S.A. 105:10762-10767(2008) [PubMed] [Europe PMC] [Abstract]
  7. "Large-scale phosphoproteome analysis of human liver tissue by enrichment and fractionation of phosphopeptides with strong anion exchange chromatography."Proteomics 8:1346-1361(2008) [PubMed] [Europe PMC] [Abstract]
  8. "Lys-N and trypsin cover complementary parts of the phosphoproteome in a refined SCX-based approach."Anal. Chem. 81:4493-4501(2009) [PubMed] [Europe PMC] [Abstract]
  9. "Large-scale proteomics analysis of the human kinome."Mol. Cell. Proteomics 8:1751-1764(2009) [PubMed] [Europe PMC] [Abstract]
  10. "Quantitative phosphoproteomic analysis of T cell receptor signaling reveals system-wide modulation of protein-protein interactions."Sci. Signal. 2:RA46-RA46(2009) [PubMed] [Europe PMC] [Abstract]
  11. "Quantitative phosphoproteomics reveals widespread full phosphorylation site occupancy during mitosis."Sci. Signal. 3:RA3-RA3(2010) [PubMed] [Europe PMC] [Abstract]
  12. "Initial characterization of the human central proteome."BMC Syst. Biol. 5:17-17(2011) [PubMed] [Europe PMC] [Abstract]
  13. "System-wide temporal characterization of the proteome and phosphoproteome of human embryonic stem cell differentiation."Sci. Signal. 4:RS3-RS3(2011) [PubMed] [Europe PMC] [Abstract]
  14. "An enzyme assisted RP-RPLC approach for in-depth analysis of human liver phosphoproteome."J. Proteomics 96:253-262(2014) [PubMed] [Europe PMC] [Abstract]