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Pleiomorphic Adenoma Gene 1 (PLAG1)

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PSA; SGPA; Zinc finger protein PLAG1

Pleiomorphic Adenoma Gene 1 (PLAG1)
CCC H381
HGNC 9045
MGI 1891916
PubMed 11549588
RGD 1305286
UniProt Q6DJT9
Wiki PLAG1
Pleomorphic adenoma gene 1 encodes a zinc finger protein with 2 putative nuclear localization signals. PLAG1, which is developmentally regulated, has been shown to be consistently rearranged in pleomorphic adenomas of the salivary glands. PLAG1 is activated by the reciprocal chromosomal translocations involving 8q12 in a subset of salivary gland pleomorphic adenomas.
Pleomorphic adenomas are benign epithelial tumors originating from the major and minor salivary glands. They are characterized by recurrent chromosome translocations; the most common abnormalities involve chromosome 8, with consistent breakpoints at band q12.

Organism species: Homo sapiens (Human)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins n/a Recombinant Pleiomorphic Adenoma Gene 1 (PLAG1) Recombinant Protein Customized Service Offer
Antibodies n/a Monoclonal Antibody to Pleiomorphic Adenoma Gene 1 (PLAG1) Monoclonal Antibody Customized Service Offer
n/a Polyclonal Antibody to Pleiomorphic Adenoma Gene 1 (PLAG1) Polyclonal Antibody Customized Service Offer
Assay Kits n/a CLIA Kit for Pleiomorphic Adenoma Gene 1 (PLAG1) CLIA Kit Customized Service Offer
n/a ELISA Kit for Pleiomorphic Adenoma Gene 1 (PLAG1) ELISA Kit Customized Service Offer

Organism species: Mus musculus (Mouse)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins n/a Recombinant Pleiomorphic Adenoma Gene 1 (PLAG1) Recombinant Protein Customized Service Offer
Antibodies n/a Monoclonal Antibody to Pleiomorphic Adenoma Gene 1 (PLAG1) Monoclonal Antibody Customized Service Offer
n/a Polyclonal Antibody to Pleiomorphic Adenoma Gene 1 (PLAG1) Polyclonal Antibody Customized Service Offer
Assay Kits n/a CLIA Kit for Pleiomorphic Adenoma Gene 1 (PLAG1) CLIA Kit Customized Service Offer
n/a ELISA Kit for Pleiomorphic Adenoma Gene 1 (PLAG1) ELISA Kit Customized Service Offer

Organism species: Rattus norvegicus (Rat)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins n/a Recombinant Pleiomorphic Adenoma Gene 1 (PLAG1) Recombinant Protein Customized Service Offer
Antibodies n/a Monoclonal Antibody to Pleiomorphic Adenoma Gene 1 (PLAG1) Monoclonal Antibody Customized Service Offer
n/a Polyclonal Antibody to Pleiomorphic Adenoma Gene 1 (PLAG1) Polyclonal Antibody Customized Service Offer
Assay Kits n/a CLIA Kit for Pleiomorphic Adenoma Gene 1 (PLAG1) CLIA Kit Customized Service Offer
n/a ELISA Kit for Pleiomorphic Adenoma Gene 1 (PLAG1) ELISA Kit Customized Service Offer
  1. "Promoter swapping between the genes for a novel zinc finger protein and beta-catenin in pleiomorphic adenomas with t(3;8)(p21;q12) translocations."Nat. Genet. 15:170-174(1997) [PubMed] [Europe PMC] [Abstract]
  2. "Complete sequencing and characterization of 21,243 full-length human cDNAs." Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract]
  3. "DNA sequence and analysis of human chromosome 8." Nature 439:331-335(2006) [PubMed] [Europe PMC] [Abstract]
  4. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
  5. "Transcriptional activation capacity of the novel PLAG family of zinc finger proteins."J. Biol. Chem. 273:23026-23032(1998) [PubMed] [Europe PMC] [Abstract]
  6. "The recurrent translocation t(5;8)(p13;q12) in pleomorphic adenomas results in upregulation of PLAG1 gene expression under control of the LIFR promoter."Oncogene 16:1409-1416(1998) [PubMed] [Europe PMC] [Abstract]
  7. "Conserved mechanism of PLAG1 activation in salivary gland tumors with and without chromosome 8q12 abnormalities: identification of SII as a new fusion partner gene."Cancer Res. 59:918-923(1999) [PubMed] [Europe PMC] [Abstract]
  8. "PLAG1, the main translocation target in pleomorphic adenoma of the salivary glands, is a positive regulator of IGF-II."Cancer Res. 60:106-113(2000) [PubMed] [Europe PMC] [Abstract]
  9. "PLAG1 fusion oncogenes in lipoblastoma."Cancer Res. 60:4869-4872(2000) [PubMed] [Europe PMC] [Abstract]
  10. "The tumorigenic diversity of the three PLAG family members is associated with different DNA binding capacities."Cancer Res. 62:1510-1517(2002) [PubMed] [Europe PMC] [Abstract]
  11. "Identification of a karyopherin alpha 2 recognition site in PLAG1, which functions as a nuclear localization signal."J. Biol. Chem. 277:19673-19678(2002) [PubMed] [Europe PMC] [Abstract]
  12. "Amplification and overexpression of the IGF2 regulator PLAG1 in hepatoblastoma."Genes Chromosomes Cancer 39:126-137(2004) [PubMed] [Europe PMC] [Abstract]
  13. "Repression of the transactivating capacity of the oncoprotein PLAG1 by SUMOylation."J. Biol. Chem. 279:36121-36131(2004) [PubMed] [Europe PMC] [Abstract]
  14. "Microarray screening for target genes of the proto-oncogene PLAG1."Oncogene 23:179-191(2004) [PubMed] [Europe PMC] [Abstract]
  15. "PLAG1-HAS2 fusion in lipoblastoma with masked 8q intrachromosomal rearrangement."Cancer Genet. Cytogenet. 156:183-184(2005) [PubMed] [Europe PMC] [Abstract]
  16. "Sumoylation and acetylation play opposite roles in the transactivation of PLAG1 and PLAGL2."J. Biol. Chem. 280:40773-40781(2005) [PubMed] [Europe PMC] [Abstract]
  17. "CHCHD7-PLAG1 and TCEA1-PLAG1 gene fusions resulting from cryptic, intrachromosomal 8q rearrangements in pleomorphic salivary gland adenomas."Genes Chromosomes Cancer 45:820-828(2006) [PubMed] [Europe PMC] [Abstract]