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Paired Like Homeodomain Transcription Factor 3 (PITX3)

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PTX3; Paired-Like Homeodomain Transcription Factor 3; Pituitary homeobox 3; Homeobox protein PITX3

Paired Like Homeodomain Transcription Factor 3 (PITX3)
CCC H385
HGNC 9006
MGI 1100498
PubMed 9620774
RGD 3332
UniProt O75364
Wiki PITX3
PITX3 encodes a member of the RIEG/PITX homeobox family, which is in the bicoid class of homeodomain proteins. Members of this family act as transcription factors. Mutations of this gene have been associated with anterior segment mesenchymal dysgenesis (ASMD) and congenital cataracts. This protein is involved in lens formation during eye development.
MiR133B regulates the maturation and function of midbrain dopaminergic neurons within a negative feedback circuit that includes the paired-like homeodomain transcription factor PITX3. The authors found that PITX3 induces transcription of miR133B, which in turn suppresses PITX3 expression.

Organism species: Homo sapiens (Human)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins n/a Recombinant Paired Like Homeodomain Transcription Factor 3 (PITX3) Recombinant Protein Customized Service Offer
Antibodies n/a Monoclonal Antibody to Paired Like Homeodomain Transcription Factor 3 (PITX3) Monoclonal Antibody Customized Service Offer
n/a Polyclonal Antibody to Paired Like Homeodomain Transcription Factor 3 (PITX3) Polyclonal Antibody Customized Service Offer
Assay Kits n/a CLIA Kit for Paired Like Homeodomain Transcription Factor 3 (PITX3) CLIA Kit Customized Service Offer
n/a ELISA Kit for Paired Like Homeodomain Transcription Factor 3 (PITX3) ELISA Kit Customized Service Offer

Organism species: Mus musculus (Mouse)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins n/a Recombinant Paired Like Homeodomain Transcription Factor 3 (PITX3) Recombinant Protein Customized Service Offer
Antibodies n/a Monoclonal Antibody to Paired Like Homeodomain Transcription Factor 3 (PITX3) Monoclonal Antibody Customized Service Offer
n/a Polyclonal Antibody to Paired Like Homeodomain Transcription Factor 3 (PITX3) Polyclonal Antibody Customized Service Offer
Assay Kits n/a CLIA Kit for Paired Like Homeodomain Transcription Factor 3 (PITX3) CLIA Kit Customized Service Offer
n/a ELISA Kit for Paired Like Homeodomain Transcription Factor 3 (PITX3) ELISA Kit Customized Service Offer

Organism species: Rattus norvegicus (Rat)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins n/a Recombinant Paired Like Homeodomain Transcription Factor 3 (PITX3) Recombinant Protein Customized Service Offer
Antibodies n/a Monoclonal Antibody to Paired Like Homeodomain Transcription Factor 3 (PITX3) Monoclonal Antibody Customized Service Offer
n/a Polyclonal Antibody to Paired Like Homeodomain Transcription Factor 3 (PITX3) Polyclonal Antibody Customized Service Offer
Assay Kits n/a CLIA Kit for Paired Like Homeodomain Transcription Factor 3 (PITX3) CLIA Kit Customized Service Offer
n/a ELISA Kit for Paired Like Homeodomain Transcription Factor 3 (PITX3) ELISA Kit Customized Service Offer
  1. "A novel homeobox gene PITX3 is mutated in families with autosomal-dominant cataracts and ASMD."Nat. Genet. 19:167-170(1998) [PubMed] [Europe PMC] [Abstract]
  2. "The DNA sequence and comparative analysis of human chromosome 10." Nature 429:375-381(2004) [PubMed] [Europe PMC] [Abstract]
  3. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
  4. "Recurrent 17 bp duplication in PITX3 is primarily associated with posterior polar cataract (CPP4)."J. Med. Genet. 41:E109-E109(2004) [PubMed] [Europe PMC] [Abstract]
  5. "Lys-N and trypsin cover complementary parts of the phosphoproteome in a refined SCX-based approach."Anal. Chem. 81:4493-4501(2009) [PubMed] [Europe PMC] [Abstract]