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Paired Like Homeodomain Transcription Factor 1 (PITX1)

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PTX1; BFT; POTX; Pituitary homeobox 1; Hindlimb-expressed homeobox protein backfoot; Homeobox protein PITX1

Paired Like Homeodomain Transcription Factor 1 (PITX1)
CCC H387
HGNC 9004
MGI 107374
PubMed 21775501
RGD 69253
UniProt P78337
Wiki PITX1
PITX1 encodes a member of the RIEG/PITX homeobox family, which is in the bicoid class of homeodomain proteins. According to an October 2008 press release by the Washington University School of Medicine, the gene is the first gene thought to be involved with clubfoot. Members of this family are involved in organ development and left-right asymmetry. This protein acts as a transcriptional regulator involved in basal and hormone-regulated activity of prolactin and it could be associated with autism.
The putative encoded mouse and human proteins share 100% identity in the homeodomain and are 88% and 97% conserved in the N- and C-terminal regions, respectively. Intron/exon boundaries are also conserved.

Organism species: Homo sapiens (Human)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins n/a Recombinant Paired Like Homeodomain Transcription Factor 1 (PITX1) Recombinant Protein Customized Service Offer
Antibodies n/a Monoclonal Antibody to Paired Like Homeodomain Transcription Factor 1 (PITX1) Monoclonal Antibody Customized Service Offer
n/a Polyclonal Antibody to Paired Like Homeodomain Transcription Factor 1 (PITX1) Polyclonal Antibody Customized Service Offer
Assay Kits n/a CLIA Kit for Paired Like Homeodomain Transcription Factor 1 (PITX1) CLIA Kit Customized Service Offer
n/a ELISA Kit for Paired Like Homeodomain Transcription Factor 1 (PITX1) ELISA Kit Customized Service Offer

Organism species: Mus musculus (Mouse)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins n/a Recombinant Paired Like Homeodomain Transcription Factor 1 (PITX1) Recombinant Protein Customized Service Offer
Antibodies n/a Monoclonal Antibody to Paired Like Homeodomain Transcription Factor 1 (PITX1) Monoclonal Antibody Customized Service Offer
n/a Polyclonal Antibody to Paired Like Homeodomain Transcription Factor 1 (PITX1) Polyclonal Antibody Customized Service Offer
Assay Kits n/a CLIA Kit for Paired Like Homeodomain Transcription Factor 1 (PITX1) CLIA Kit Customized Service Offer
n/a ELISA Kit for Paired Like Homeodomain Transcription Factor 1 (PITX1) ELISA Kit Customized Service Offer

Organism species: Rattus norvegicus (Rat)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins n/a Recombinant Paired Like Homeodomain Transcription Factor 1 (PITX1) Recombinant Protein Customized Service Offer
Antibodies n/a Monoclonal Antibody to Paired Like Homeodomain Transcription Factor 1 (PITX1) Monoclonal Antibody Customized Service Offer
n/a Polyclonal Antibody to Paired Like Homeodomain Transcription Factor 1 (PITX1) Polyclonal Antibody Customized Service Offer
Assay Kits n/a CLIA Kit for Paired Like Homeodomain Transcription Factor 1 (PITX1) CLIA Kit Customized Service Offer
n/a ELISA Kit for Paired Like Homeodomain Transcription Factor 1 (PITX1) ELISA Kit Customized Service Offer
  1. "Backfoot, a novel homeobox gene, maps to human chromosome 5 (BFT) and mouse chromosome 13 (Bft)."Genomics 40:108-113(1997) [PubMed] [Europe PMC] [Abstract]
  2. "Human and murine PTX1/Ptx1 gene maps to the region for Treacher Collins syndrome."Mamm. Genome 8:841-845(1997) [PubMed] [Europe PMC] [Abstract]
  3. "Complete sequencing and characterization of 21,243 full-length human cDNAs." Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract]
  4. "The DNA sequence and comparative analysis of human chromosome 5." Nature 431:268-274(2004) [PubMed] [Europe PMC] [Abstract]
  5. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
  6. "A quantitative atlas of mitotic phosphorylation."Proc. Natl. Acad. Sci. U.S.A. 105:10762-10767(2008) [PubMed] [Europe PMC] [Abstract]
  7. "Homeotic arm-to-leg transformation associated with genomic rearrangements at the PITX1 locus."Am. J. Hum. Genet. 91:629-635(2012) [PubMed] [Europe PMC] [Abstract]
  8. "Deletions in PITX1 cause a spectrum of lower-limb malformations including mirror-image polydactyly."Eur. J. Hum. Genet. 20:705-708(2012) [PubMed] [Europe PMC] [Abstract]
  9. "N-terminal acetylome analyses and functional insights of the N-terminal acetyltransferase NatB."Proc. Natl. Acad. Sci. U.S.A. 109:12449-12454(2012) [PubMed] [Europe PMC] [Abstract]
  10. "Asymmetric lower-limb malformations in individuals with homeobox PITX1 gene mutation."Am. J. Hum. Genet. 83:616-622(2008) [PubMed] [Europe PMC] [Abstract]