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Phosphatidylinositol Glycan P (PIGP)

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DCRC; DSRC; DSCR5; Down Syndrome Critical Region Gene 5; Phosphatidylinositol-n-Acetylglucosaminyltranferase; Phosphatidylinositol Glycan Anchor Biosynthesis,Class P

Phosphatidylinositol Glycan P (PIGP)
CCC H396
HGNC 3046
MGI 1860433
PubMed 18023542
RGD 1307205
UniProt P57054
Wiki PIGP
PIGP encodes an enzyme involved in the first step of glycosylphosphatidylinositol (GPI)-anchor biosynthesis. The GPI-anchor is a glycolipid found on many blood cells that serves to anchor proteins to the cell surface.
The encoded protein is a component of the GPI-N-acetylglucosaminyltransferase complex that catalyzes the transfer of N-acetylglucosamine (GlcNAc) from UDP-GlcNAc to phosphatidylinositol (PI). This gene is located in the Down Syndrome critical region on chromosome 21 and is a candidate for the pathogenesis of Down syndrome. Alternatively spliced transcript variants encoding different isoforms have been described.The gene is highly expressed in human heart, liver, and skeletal muscle.

Organism species: Homo sapiens (Human)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins n/a Recombinant Phosphatidylinositol Glycan P (PIGP) Recombinant Protein Customized Service Offer
Antibodies n/a Monoclonal Antibody to Phosphatidylinositol Glycan P (PIGP) Monoclonal Antibody Customized Service Offer
n/a Polyclonal Antibody to Phosphatidylinositol Glycan P (PIGP) Polyclonal Antibody Customized Service Offer
Assay Kits n/a CLIA Kit for Phosphatidylinositol Glycan P (PIGP) CLIA Kit Customized Service Offer
n/a ELISA Kit for Phosphatidylinositol Glycan P (PIGP) ELISA Kit Customized Service Offer

Organism species: Mus musculus (Mouse)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins n/a Recombinant Phosphatidylinositol Glycan P (PIGP) Recombinant Protein Customized Service Offer
Antibodies n/a Monoclonal Antibody to Phosphatidylinositol Glycan P (PIGP) Monoclonal Antibody Customized Service Offer
n/a Polyclonal Antibody to Phosphatidylinositol Glycan P (PIGP) Polyclonal Antibody Customized Service Offer
Assay Kits n/a CLIA Kit for Phosphatidylinositol Glycan P (PIGP) CLIA Kit Customized Service Offer
n/a ELISA Kit for Phosphatidylinositol Glycan P (PIGP) ELISA Kit Customized Service Offer

Organism species: Rattus norvegicus (Rat)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins n/a Recombinant Phosphatidylinositol Glycan P (PIGP) Recombinant Protein Customized Service Offer
Antibodies n/a Monoclonal Antibody to Phosphatidylinositol Glycan P (PIGP) Monoclonal Antibody Customized Service Offer
n/a Polyclonal Antibody to Phosphatidylinositol Glycan P (PIGP) Polyclonal Antibody Customized Service Offer
Assay Kits n/a CLIA Kit for Phosphatidylinositol Glycan P (PIGP) CLIA Kit Customized Service Offer
n/a ELISA Kit for Phosphatidylinositol Glycan P (PIGP) ELISA Kit Customized Service Offer
  1. "Isolation of two novel genes, DSCR5 and DSCR6, from Down syndrome critical region on human chromosome 21q22.2."Biochem. Biophys. Res. Commun. 271:693-698(2000) [PubMed] [Europe PMC] [Abstract]
  2. "A novel gene, DSCR5, from the distal Down syndrome critical region on chromosome 21q22.2."DNA Res. 7:207-212(2000) [PubMed] [Europe PMC] [Abstract]
  3. "Initial enzyme for glycosylphosphatidylinositol biosynthesis requires PIG-P and is regulated by DPM2."EMBO J. 19:4402-4411(2000) [PubMed] [Europe PMC] [Abstract]
  4. "Complete sequencing and characterization of 21,243 full-length human cDNAs." Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract]
  5. "Human protein factory for converting the transcriptome into an in vitro-expressed proteome." Nat. Methods 5:1011-1017(2008) [PubMed] [Europe PMC] [Abstract]
  6. "The DNA sequence of human chromosome 21." Nature 405:311-319(2000) [PubMed] [Europe PMC] [Abstract]
  7. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]