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Phosphatidylinositol Glycan K (PIGK)

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GPI8; hGPI8; Phosphatidylinositol Glycan Anchor Biosynthesis,Class K; GPI-anchor transamidase

Phosphatidylinositol Glycan K (PIGK)
CCC H398
HGNC 8965
MGI 1913863
PubMed 9356492
RGD 1306753
UniProt Q92643
Wiki PIGK
Glycosylphosphatidylinositol (GPI) is a membrane anchor for cell surface proteins. PIGK is a subunit of the GPI transamidase complex that catalyzes the attachment of preformed GPI to proteins containing a C-terminal GPI attachment site. PIGK encodes a member of the cysteine protease family C13 that is involved in glycosylphosphatidylinositol (GPI)-anchor biosynthesis. The GPI-anchor is a glycolipid found on many blood cells and serves to anchor proteins to the cell surface. This protein is a member of the multisubunit enzyme, GPI transamidase and is thought to be its enzymatic component. GPI transamidase mediates GPI anchoring in the endoplasmic reticulum, by catalyzing the transfer of fully assembled GPI units to proteins.

Organism species: Homo sapiens (Human)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins n/a Recombinant Phosphatidylinositol Glycan K (PIGK) Recombinant Protein Customized Service Offer
Antibodies n/a Monoclonal Antibody to Phosphatidylinositol Glycan K (PIGK) Monoclonal Antibody Customized Service Offer
n/a Polyclonal Antibody to Phosphatidylinositol Glycan K (PIGK) Polyclonal Antibody Customized Service Offer
Assay Kits n/a CLIA Kit for Phosphatidylinositol Glycan K (PIGK) CLIA Kit Customized Service Offer
n/a ELISA Kit for Phosphatidylinositol Glycan K (PIGK) ELISA Kit Customized Service Offer

Organism species: Mus musculus (Mouse)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins n/a Recombinant Phosphatidylinositol Glycan K (PIGK) Recombinant Protein Customized Service Offer
Antibodies n/a Monoclonal Antibody to Phosphatidylinositol Glycan K (PIGK) Monoclonal Antibody Customized Service Offer
n/a Polyclonal Antibody to Phosphatidylinositol Glycan K (PIGK) Polyclonal Antibody Customized Service Offer
Assay Kits n/a CLIA Kit for Phosphatidylinositol Glycan K (PIGK) CLIA Kit Customized Service Offer
n/a ELISA Kit for Phosphatidylinositol Glycan K (PIGK) ELISA Kit Customized Service Offer

Organism species: Rattus norvegicus (Rat)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins n/a Recombinant Phosphatidylinositol Glycan K (PIGK) Recombinant Protein Customized Service Offer
Antibodies n/a Monoclonal Antibody to Phosphatidylinositol Glycan K (PIGK) Monoclonal Antibody Customized Service Offer
n/a Polyclonal Antibody to Phosphatidylinositol Glycan K (PIGK) Polyclonal Antibody Customized Service Offer
Assay Kits n/a CLIA Kit for Phosphatidylinositol Glycan K (PIGK) CLIA Kit Customized Service Offer
n/a ELISA Kit for Phosphatidylinositol Glycan K (PIGK) ELISA Kit Customized Service Offer
  1. "Yeast Gpi8p is essential for GPI anchor attachment onto proteins."EMBO J. 15:6575-6583(1996) [PubMed] [Europe PMC] [Abstract]
  2. "The affected gene underlying the class K glycosylphosphatidylinositol (GPI) surface protein defect codes for the GPI transamidase."Proc. Natl. Acad. Sci. U.S.A. 94:12580-12585(1997) [PubMed] [Europe PMC] [Abstract]
  3. "Complete sequencing and characterization of 21,243 full-length human cDNAs." Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract]
  4. "The DNA sequence and biological annotation of human chromosome 1." Nature 441:315-321(2006) [PubMed] [Europe PMC] [Abstract]
  5. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
  6. "Gaa1p and gpi8p are components of a glycosylphosphatidylinositol (GPI) transamidase that mediates attachment of GPI to proteins."Mol. Biol. Cell 11:1523-1533(2000) [PubMed] [Europe PMC] [Abstract]
  7. "PIG-S and PIG-T, essential for GPI anchor attachment to proteins, form a complex with GAA1 and GPI8."EMBO J. 20:4088-4098(2001) [PubMed] [Europe PMC] [Abstract]
  8. "Two subunits of glycosylphosphatidylinositol transamidase, GPI8 and PIG-T, form a functionally important intermolecular disulfide bridge."J. Biol. Chem. 278:13959-13967(2003) [PubMed] [Europe PMC] [Abstract]
  9. "Initial characterization of the human central proteome."BMC Syst. Biol. 5:17-17(2011) [PubMed] [Europe PMC] [Abstract]