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Phosphatidylinositol Glycan L (PIGL)

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N-Acetylglucosaminylphosphatidylinositol Deacetylase; Phosphatidylinositol Glycan Anchor Biosynthesis,Class L; N-acetylglucosaminyl-phosphatidylinositol de-N-acetylase

Phosphatidylinositol Glycan L (PIGL)
CCC H399
HGNC 8966
MGI 2681271
RGD 620437
UniProt Q9Y2B2
Glycosylphosphatidylinositol (GPI) is used as a membrane anchor by many eukaryotic cell surface proteins. The first step in GPI biosynthesis involves the transfer of N-acetylglucosamine (GlcNAc) from UDP-GlcNAc to phosphatidylinositol (PI) . The second step is de-N-acetylation of GlcNAc-PI.
PIGL encodes a deduced 252-amino acid protein that shares 77% identity with the rat protein. Using transfection into mammalian PIGL-deficient cells, Watanabe et al. (1999) demonstrated that S. cerevisiae Gpi12 is the ortholog of human and rat PIGL. Disruption of Gpi12 in yeast resulted in a lethal phenotype. Using purified, recombinant rat PIGL, Watanabe et al. (1999) demonstrated that PIGL has GlcNAc-PI de-N-acetylase activity in vitro, which is enhanced by metal ions.

Organism species: Homo sapiens (Human)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins RPH399Hu01 Recombinant Phosphatidylinositol Glycan L (PIGL) Positive Control; Immunogen; SDS-PAGE; WB.
Antibodies n/a Monoclonal Antibody to Phosphatidylinositol Glycan L (PIGL) Monoclonal Antibody Customized Service Offer
n/a Polyclonal Antibody to Phosphatidylinositol Glycan L (PIGL) Polyclonal Antibody Customized Service Offer
Assay Kits SEH399Hu ELISA Kit for Phosphatidylinositol Glycan L (PIGL) Enzyme-linked immunosorbent assay for Antigen Detection.

Organism species: Mus musculus (Mouse)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins n/a Recombinant Phosphatidylinositol Glycan L (PIGL) Recombinant Protein Customized Service Offer
Antibodies n/a Monoclonal Antibody to Phosphatidylinositol Glycan L (PIGL) Monoclonal Antibody Customized Service Offer
n/a Polyclonal Antibody to Phosphatidylinositol Glycan L (PIGL) Polyclonal Antibody Customized Service Offer
Assay Kits n/a CLIA Kit for Phosphatidylinositol Glycan L (PIGL) CLIA Kit Customized Service Offer
n/a ELISA Kit for Phosphatidylinositol Glycan L (PIGL) ELISA Kit Customized Service Offer

Organism species: Rattus norvegicus (Rat)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins n/a Recombinant Phosphatidylinositol Glycan L (PIGL) Recombinant Protein Customized Service Offer
Antibodies n/a Monoclonal Antibody to Phosphatidylinositol Glycan L (PIGL) Monoclonal Antibody Customized Service Offer
n/a Polyclonal Antibody to Phosphatidylinositol Glycan L (PIGL) Polyclonal Antibody Customized Service Offer
Assay Kits n/a CLIA Kit for Phosphatidylinositol Glycan L (PIGL) CLIA Kit Customized Service Offer
n/a ELISA Kit for Phosphatidylinositol Glycan L (PIGL) ELISA Kit Customized Service Offer
  1. "Mammalian PIG-L and its yeast homologue Gpi12p are N-acetylglucosaminylphosphatidylinositol de-N-acetylases essential in glycosylphosphatidylinositol biosynthesis."Biochem. J. 339:185-192(1999) [PubMed] [Europe PMC] [Abstract]
  2. "Complete sequencing and characterization of 21,243 full-length human cDNAs." Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract]
  3. "DNA sequence of human chromosome 17 and analysis of rearrangement in the human lineage." Nature 440:1045-1049(2006) [PubMed] [Europe PMC] [Abstract]
  4. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
  5. "Mutations in the glycosylphosphatidylinositol gene PIGL cause CHIME syndrome."Am. J. Hum. Genet. 90:685-688(2012) [PubMed] [Europe PMC] [Abstract]