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Pyruvate Carboxylase (PC)

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PCB

Pyruvate Carboxylase (PC)
CCC H430
HGNC 8636
MGI 97520
PubMed 18613815
RGD 3262
UniProt P11498
Wiki PC
Pyruvate carboxylase (PC) is an enzyme of the ligase class that catalyzes the reversible carboxylation of pyruvate to form oxaloacetate (OAA).It is an important anaplerotic reaction that provides oxaloacetate precursor for the citric acid cycle. The enzyme is a mitochondrial protein containing a biotin prosthetic group, requiring magnesium or manganese and acetyl CoA, and occurs in liver but not in muscle.
Pyruvate carboxylasehas been found in a wide variety of prokaryotes and eukaryotes including fungi, bacteria, plants, and animals. In mammals, PC plays a crucial role in gluconeogenesis and lipogenesis, in the biosynthesis of neurotransmitters, and in glucose-induced insulin secretion by pancreatic islets.

Organism species: Homo sapiens (Human)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins RPH430Hu01 Recombinant Pyruvate Carboxylase (PC) Positive Control; Immunogen; SDS-PAGE; WB.
APH430Hu01 Active Pyruvate Carboxylase (PC) Cell culture; Activity Assays.
Antibodies MAH430Hu21 Monoclonal Antibody to Pyruvate Carboxylase (PC) WB; IHC; ICC; IP.
PAH430Hu01 Polyclonal Antibody to Pyruvate Carboxylase (PC) WB; IHC; ICC; IP.
Assay Kits SEH430Hu ELISA Kit for Pyruvate Carboxylase (PC) Enzyme-linked immunosorbent assay for Antigen Detection.

Organism species: Mus musculus (Mouse)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins RPH430Mu01 Recombinant Pyruvate Carboxylase (PC) Positive Control; Immunogen; SDS-PAGE; WB.
RPH430Mu02 Recombinant Pyruvate Carboxylase (PC) Positive Control; Immunogen; SDS-PAGE; WB.
Antibodies PAH430Mu01 Polyclonal Antibody to Pyruvate Carboxylase (PC) WB; IHC; ICC; IP.
PAH430Mu02 Polyclonal Antibody to Pyruvate Carboxylase (PC) WB; IHC; ICC; IP.
Assay Kits SEH430Mu ELISA Kit for Pyruvate Carboxylase (PC) Enzyme-linked immunosorbent assay for Antigen Detection.

Organism species: Rattus norvegicus (Rat)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins n/a Recombinant Pyruvate Carboxylase (PC) Recombinant Protein Customized Service Offer
Antibodies n/a Monoclonal Antibody to Pyruvate Carboxylase (PC) Monoclonal Antibody Customized Service Offer
n/a Polyclonal Antibody to Pyruvate Carboxylase (PC) Polyclonal Antibody Customized Service Offer
Assay Kits n/a CLIA Kit for Pyruvate Carboxylase (PC) CLIA Kit Customized Service Offer
n/a ELISA Kit for Pyruvate Carboxylase (PC) ELISA Kit Customized Service Offer
  1. "Primary amino acid sequence and structure of human pyruvate carboxylase."Biochim. Biophys. Acta 1227:46-52(1994) [PubMed] [Europe PMC] [Abstract]
  2. "cDNA cloning of human kidney pyruvate carboxylase."Biochem. Biophys. Res. Commun. 202:1009-1014(1994) [PubMed] [Europe PMC] [Abstract]
  3. "Complete sequencing and characterization of 21,243 full-length human cDNAs." Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract]
  4. "Human chromosome 11 DNA sequence and analysis including novel gene identification." Nature 440:497-500(2006) [PubMed] [Europe PMC] [Abstract]
  5. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
  6. "Sequence homology around the biotin-binding site of human propionyl-CoA carboxylase and pyruvate carboxylase."Arch. Biochem. Biophys. 254:631-636(1987) [PubMed] [Europe PMC] [Abstract]
  7. "Molecular cloning of a cDNA for human pyruvate carboxylase. Structural relationship to other biotin-containing carboxylases and regulation of mRNA content in differentiating preadipocytes."J. Biol. Chem. 259:12831-12837(1984) [PubMed] [Europe PMC] [Abstract]
  8. "Lysine acetylation targets protein complexes and co-regulates major cellular functions."Science 325:834-840(2009) [PubMed] [Europe PMC] [Abstract]
  9. "Initial characterization of the human central proteome."BMC Syst. Biol. 5:17-17(2011) [PubMed] [Europe PMC] [Abstract]
  10. "An enzyme assisted RP-RPLC approach for in-depth analysis of human liver phosphoproteome."J. Proteomics 96:253-262(2014) [PubMed] [Europe PMC] [Abstract]
  11. "Crystal structures of human and Staphylococcus aureus pyruvate carboxylase and molecular insights into the carboxyltransfer reaction."Nat. Struct. Mol. Biol. 15:295-302(2008) [PubMed] [Europe PMC] [Abstract]
  12. "Amerindian pyruvate carboxylase deficiency is associated with two distinct missense mutations."Am. J. Hum. Genet. 62:1312-1319(1998) [PubMed] [Europe PMC] [Abstract]
  13. "Molecular characterization of pyruvate carboxylase deficiency in two consanguineous families."Pediatr. Res. 43:579-584(1998) [PubMed] [Europe PMC] [Abstract]
  14. "Structural insights on pathogenic effects of novel mutations causing pyruvate carboxylase deficiency."Hum. Mutat. 30:734-740(2009) [PubMed] [Europe PMC] [Abstract]