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PDZ Binding Kinase (PBK)

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SPK; Nori-3; TOPK; CT84; Spermatogenesis-related protein kinase; T-LAK Cell-Originated Protein Kinase; Lymphokine-activated killer T-cell-originated protein kinase

PDZ Binding Kinase (PBK)
CCC H436
HGNC 18282
MGI 1289156
PubMed 10781613
RGD 1309565
UniProt Q96KB5
Wiki PBK
PDZ Binding Kinase is a serine/threonine kinase related to the dual specific mitogen-activated protein kinase kinase (MAPKK) family. Evidence suggests that mitotic phosphorylation is required for its catalytic activity. This mitotic kinase may be involved in the activation of lymphoid cells and support testicular functions, with a suggested role in the process of spermatogenesis.
The variants differ at their 5-prime ends and encode the same protein, a deduced 322-amino acid serine/threonine kinase with a calculated molecular mass of 37.4 kD. Northern blot analysis of 12 human tissues detected transcripts of 1.9 and 2 kb in testis only. RT-PCR detected TOPK in activated, but not deactivated, T-LAK cells.

Organism species: Homo sapiens (Human)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins n/a Recombinant PDZ Binding Kinase (PBK) Recombinant Protein Customized Service Offer
Antibodies n/a Monoclonal Antibody to PDZ Binding Kinase (PBK) Monoclonal Antibody Customized Service Offer
n/a Polyclonal Antibody to PDZ Binding Kinase (PBK) Polyclonal Antibody Customized Service Offer
Assay Kits n/a CLIA Kit for PDZ Binding Kinase (PBK) CLIA Kit Customized Service Offer
n/a ELISA Kit for PDZ Binding Kinase (PBK) ELISA Kit Customized Service Offer

Organism species: Mus musculus (Mouse)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins n/a Recombinant PDZ Binding Kinase (PBK) Recombinant Protein Customized Service Offer
Antibodies n/a Monoclonal Antibody to PDZ Binding Kinase (PBK) Monoclonal Antibody Customized Service Offer
n/a Polyclonal Antibody to PDZ Binding Kinase (PBK) Polyclonal Antibody Customized Service Offer
Assay Kits n/a CLIA Kit for PDZ Binding Kinase (PBK) CLIA Kit Customized Service Offer
n/a ELISA Kit for PDZ Binding Kinase (PBK) ELISA Kit Customized Service Offer

Organism species: Rattus norvegicus (Rat)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins n/a Recombinant PDZ Binding Kinase (PBK) Recombinant Protein Customized Service Offer
Antibodies n/a Monoclonal Antibody to PDZ Binding Kinase (PBK) Monoclonal Antibody Customized Service Offer
n/a Polyclonal Antibody to PDZ Binding Kinase (PBK) Polyclonal Antibody Customized Service Offer
Assay Kits n/a CLIA Kit for PDZ Binding Kinase (PBK) CLIA Kit Customized Service Offer
n/a ELISA Kit for PDZ Binding Kinase (PBK) ELISA Kit Customized Service Offer
  1. "Cloning and expression of a novel MAPKK-like protein kinase, lymphokine-activated killer T-cell-originated protein kinase, specifically expressed in the testis and activated lymphoid cells."J. Biol. Chem. 275:21525-21531(2000) [PubMed] [Europe PMC] [Abstract]
  2. "Characterization of PDZ-binding kinase, a mitotic kinase."Proc. Natl. Acad. Sci. U.S.A. 97:5167-5172(2000) [PubMed] [Europe PMC] [Abstract]
  3. "PDZ-binding kinase participates in spermatogenesis."Int. J. Biochem. Cell Biol. 33:631-636(2001) [PubMed] [Europe PMC] [Abstract]
  4. "Complete sequencing and characterization of 21,243 full-length human cDNAs." Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract]
  5. "DNA sequence and analysis of human chromosome 8." Nature 439:331-335(2006) [PubMed] [Europe PMC] [Abstract]
  6. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
  7. "Attenuation of DNA damage checkpoint by PBK, a novel mitotic kinase, involves protein-protein interaction with tumor suppressor p53."Biochem. Biophys. Res. Commun. 358:181-188(2007) [PubMed] [Europe PMC] [Abstract]
  8. "Improved titanium dioxide enrichment of phosphopeptides from HeLa cells and high confident phosphopeptide identification by cross-validation of MS/MS and MS/MS/MS spectra."J. Proteome Res. 6:4150-4162(2007) [PubMed] [Europe PMC] [Abstract]
  9. "A quantitative atlas of mitotic phosphorylation."Proc. Natl. Acad. Sci. U.S.A. 105:10762-10767(2008) [PubMed] [Europe PMC] [Abstract]
  10. "Lys-N and trypsin cover complementary parts of the phosphoproteome in a refined SCX-based approach."Anal. Chem. 81:4493-4501(2009) [PubMed] [Europe PMC] [Abstract]
  11. "Quantitative phosphoproteomics reveals widespread full phosphorylation site occupancy during mitosis."Sci. Signal. 3:RA3-RA3(2010) [PubMed] [Europe PMC] [Abstract]
  12. "Initial characterization of the human central proteome."BMC Syst. Biol. 5:17-17(2011) [PubMed] [Europe PMC] [Abstract]
  13. "Comparative large-scale characterisation of plant vs. mammal proteins reveals similar and idiosyncratic N-alpha acetylation features."Mol. Cell. Proteomics 11:M111.015131-M111.015131(2012) [PubMed] [Europe PMC] [Abstract]
  14. "Patterns of somatic mutation in human cancer genomes." Nature 446:153-158(2007) [PubMed] [Europe PMC] [Abstract]