Parvin Gamma (PARVg)

Members of the parvin family, including PARVG, are actin-binding proteins associated with focal contacts.Northern blot analysis revealed a strong smeared signal in heart, liver, and several other tissues. Bands of about 1.6 and 4.0 kb were detected in peripheral blood and spleen. RNA dot blot analysis detected highest expression in lymphatic organs and moderate expression in the digestive tract (stomach, duodenum, jejunum, ileum, ileocecum, and appendix), lung, and liver. In contrast, mouse Parvg showed highest expression in testis, where there were at least 6 mRNA species. A 2.8-kb Parvg transcript was expressed highly in spleen, moderately in lung, and weakly in brain and heart. Parvg was expressed throughout mouse embryonic development, with downregulation at embryonic day 11.