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Paired Box Gene 4 (PAX4)

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MODY9

Paired Box Gene 4 (PAX4)
CCC H444
HGNC 8618
MGI 97488
PubMed 19665969
RGD 620433
UniProt O43316
Wiki PAX4
PAX4 is a member of the paired box (PAX) family of transcription factors. Members of this gene family typically contain a paired box domain, an octapeptide, and a paired-type homeodomain. These genes play critical roles during fetal development and cancer growth. The paired box gene 4 is involved in pancreatic islet development and mouse studies have demonstrated a role for this gene in differentiation of insulin-producing beta cells.
The human PAX4 gene encodes a deduced 350-amino acid protein that is 80% identical to the deduced mouse Pax4 protein. RT-PCR detected mouse Pax4 expression in pancreatic islets and islet beta cell lines, but not in the other 13 adult mouse organs examined.

Organism species: Homo sapiens (Human)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins n/a Recombinant Paired Box Gene 4 (PAX4) Recombinant Protein Customized Service Offer
Antibodies n/a Monoclonal Antibody to Paired Box Gene 4 (PAX4) Monoclonal Antibody Customized Service Offer
n/a Polyclonal Antibody to Paired Box Gene 4 (PAX4) Polyclonal Antibody Customized Service Offer
Assay Kits n/a CLIA Kit for Paired Box Gene 4 (PAX4) CLIA Kit Customized Service Offer
n/a ELISA Kit for Paired Box Gene 4 (PAX4) ELISA Kit Customized Service Offer

Organism species: Mus musculus (Mouse)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins n/a Recombinant Paired Box Gene 4 (PAX4) Recombinant Protein Customized Service Offer
Antibodies n/a Monoclonal Antibody to Paired Box Gene 4 (PAX4) Monoclonal Antibody Customized Service Offer
n/a Polyclonal Antibody to Paired Box Gene 4 (PAX4) Polyclonal Antibody Customized Service Offer
Assay Kits n/a CLIA Kit for Paired Box Gene 4 (PAX4) CLIA Kit Customized Service Offer
n/a ELISA Kit for Paired Box Gene 4 (PAX4) ELISA Kit Customized Service Offer

Organism species: Rattus norvegicus (Rat)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins n/a Recombinant Paired Box Gene 4 (PAX4) Recombinant Protein Customized Service Offer
Antibodies n/a Monoclonal Antibody to Paired Box Gene 4 (PAX4) Monoclonal Antibody Customized Service Offer
n/a Polyclonal Antibody to Paired Box Gene 4 (PAX4) Polyclonal Antibody Customized Service Offer
Assay Kits n/a CLIA Kit for Paired Box Gene 4 (PAX4) CLIA Kit Customized Service Offer
n/a ELISA Kit for Paired Box Gene 4 (PAX4) ELISA Kit Customized Service Offer
  1. "Molecular cloning of mouse paired-box-containing gene (Pax-4) from an islet beta cell line and deduced sequence of human Pax-4."Biochem. Biophys. Res. Commun. 242:176-180(1998) [PubMed] [Europe PMC] [Abstract]
  2. "Isolation and characterization of the human PAX4 gene."Diabetes 47:1650-1653(1998) [PubMed] [Europe PMC] [Abstract]
  3. "The DNA sequence of human chromosome 7." Nature 424:157-164(2003) [PubMed] [Europe PMC] [Abstract]
  4. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
  5. "Expression of dominant negative form of PAX4 in human insulinoma."Biochem. Biophys. Res. Commun. 282:34-40(2001) [PubMed] [Europe PMC] [Abstract]
  6. "A missense mutation of Pax4 gene (R121W) is associated with type 2 diabetes in Japanese."Diabetes 50:2864-2869(2001) [PubMed] [Europe PMC] [Abstract]
  7. "PAX4 gene variations predispose to ketosis-prone diabetes."Hum. Mol. Genet. 13:3151-3159(2004) [PubMed] [Europe PMC] [Abstract]
  8. "Association of childhood type 1 diabetes mellitus with a variant of PAX4: possible link to beta cell regenerative capacity."Diabetologia 48:900-905(2005) [PubMed] [Europe PMC] [Abstract]
  9. "PAX4 mutations in Thais with maturity onset diabetes of the young."J. Clin. Endocrinol. Metab. 92:2821-2826(2007) [PubMed] [Europe PMC] [Abstract]