≡

3'-Phosphoadenosine 5'-Phosphosulfate Synthase 2 (PAPSS2)

[Edit]

SK2; ATPSK2; Sulfurylase kinase 2; Sulfate adenylyltransferase; Sulfate adenylate transferase; Adenosine-5'-phosphosulfate 3'-phosphotransferase

3'-Phosphoadenosine 5'-Phosphosulfate Synthase 2 (PAPSS2)
CCC H450
HGNC 8604
MGI 1330223
PubMed 10679223
RGD 1307012
UniProt O95340
Wiki PAPSS2
Three-prime-phosphoadenosine 5-prime-phosphosulfate (PAPS) is the sulfate donor cosubstrate for all sulfotransferase (SULT) enzymes. SULTs catalyze the sulfate conjugation of many endogenous and exogenous compounds, including drugs and other xenobiotics. In humans, PAPS is synthesized from adenosine 5-prime triphosphate (ATP) and inorganic sulfate by 2 isoforms, PAPSS1 and PAPSS2.
PAPSS2 consists of kinase and sulfurylase domains, and catalyzes 2 sequential reactions to synthesize PAPS. These reactions are catalyzed by separate enzymes encoded by 2 or 3 genes in simpler organisms. The human gene promoter has a GC-rich region with 9 potential SP1-binding sites.

Organism species: Homo sapiens (Human)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins n/a Recombinant 3'-Phosphoadenosine 5'-Phosphosulfate Synthase 2 (PAPSS2) Recombinant Protein Customized Service Offer
Antibodies n/a Monoclonal Antibody to 3'-Phosphoadenosine 5'-Phosphosulfate Synthase 2 (PAPSS2) Monoclonal Antibody Customized Service Offer
n/a Polyclonal Antibody to 3'-Phosphoadenosine 5'-Phosphosulfate Synthase 2 (PAPSS2) Polyclonal Antibody Customized Service Offer
Assay Kits n/a CLIA Kit for 3'-Phosphoadenosine 5'-Phosphosulfate Synthase 2 (PAPSS2) CLIA Kit Customized Service Offer
n/a ELISA Kit for 3'-Phosphoadenosine 5'-Phosphosulfate Synthase 2 (PAPSS2) ELISA Kit Customized Service Offer

Organism species: Mus musculus (Mouse)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins n/a Recombinant 3'-Phosphoadenosine 5'-Phosphosulfate Synthase 2 (PAPSS2) Recombinant Protein Customized Service Offer
Antibodies n/a Monoclonal Antibody to 3'-Phosphoadenosine 5'-Phosphosulfate Synthase 2 (PAPSS2) Monoclonal Antibody Customized Service Offer
n/a Polyclonal Antibody to 3'-Phosphoadenosine 5'-Phosphosulfate Synthase 2 (PAPSS2) Polyclonal Antibody Customized Service Offer
Assay Kits n/a CLIA Kit for 3'-Phosphoadenosine 5'-Phosphosulfate Synthase 2 (PAPSS2) CLIA Kit Customized Service Offer
n/a ELISA Kit for 3'-Phosphoadenosine 5'-Phosphosulfate Synthase 2 (PAPSS2) ELISA Kit Customized Service Offer

Organism species: Rattus norvegicus (Rat)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins n/a Recombinant 3'-Phosphoadenosine 5'-Phosphosulfate Synthase 2 (PAPSS2) Recombinant Protein Customized Service Offer
Antibodies n/a Monoclonal Antibody to 3'-Phosphoadenosine 5'-Phosphosulfate Synthase 2 (PAPSS2) Monoclonal Antibody Customized Service Offer
n/a Polyclonal Antibody to 3'-Phosphoadenosine 5'-Phosphosulfate Synthase 2 (PAPSS2) Polyclonal Antibody Customized Service Offer
Assay Kits n/a CLIA Kit for 3'-Phosphoadenosine 5'-Phosphosulfate Synthase 2 (PAPSS2) CLIA Kit Customized Service Offer
n/a ELISA Kit for 3'-Phosphoadenosine 5'-Phosphosulfate Synthase 2 (PAPSS2) ELISA Kit Customized Service Offer
  1. "Mutations in orthologous genes in human spondyloepimetaphyseal dysplasia and the brachymorphic mouse."Nat. Genet. 20:157-162(1998) [PubMed] [Europe PMC] [Abstract]
  2. "Human 3'-phosphoadenosine 5'-phosphosulfate synthetase 1 (PAPSS1) and PAPSS2: gene cloning, characterization and chromosomal localization."Biochem. Biophys. Res. Commun. 268:437-444(2000) [PubMed] [Europe PMC] [Abstract]
  3. "Genomic organization of the mouse and human genes encoding the ATP sulfurylase/adenosine 5'-phosphosulfate kinase isoform SK2."J. Biol. Chem. 274:33306-33312(1999) [PubMed] [Europe PMC] [Abstract]
  4. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
  5. "Distinct, autosomal recessive form of spondyloepimetaphyseal dysplasia segregating in an inbred Pakistani kindred."Am. J. Med. Genet. 78:468-473(1998) [PubMed] [Europe PMC] [Abstract]
  6. "Inactivating PAPSS2 mutations in a patient with premature pubarche."N. Engl. J. Med. 360:2310-2318(2009) [PubMed] [Europe PMC] [Abstract]
  7. "Initial characterization of the human central proteome."BMC Syst. Biol. 5:17-17(2011) [PubMed] [Europe PMC] [Abstract]
  8. "An enzyme assisted RP-RPLC approach for in-depth analysis of human liver phosphoproteome."J. Proteomics 96:253-262(2014) [PubMed] [Europe PMC] [Abstract]
  9. "Human 3'-phosphoadenosine 5'-phosphosulfate synthetase 2 (PAPSS2) pharmacogenetics: gene resequencing, genetic polymorphisms and functional characterization of variant allozymes."Pharmacogenetics 12:11-21(2002) [PubMed] [Europe PMC] [Abstract]
  10. "Spondyloepimetaphyseal dysplasia Pakistani type: expansion of the phenotype."Am. J. Med. Genet. A 161A:1300-1308(2013) [PubMed] [Europe PMC] [Abstract]
  11. "Clinical and radiographic features of the autosomal recessive form of brachyolmia caused by PAPSS2 mutations."Hum. Mutat. 34:1381-1386(2013) [PubMed] [Europe PMC] [Abstract]
  12. "PAPSS2 deficiency causes androgen excess via impaired DHEA sulfation - in vitro and in vivo studies in a family harboring two novel PAPSS2 mutations."J. Clin. Endocrinol. Metab. 2015:JC20143556-JC20143556(2015) [PubMed] [Europe PMC] [Abstract]