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3'-Phosphoadenosine 5'-Phosphosulfate Synthase 1 (PAPSS1)

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SK1; ATPSK1; PAPSS; Sulfurylase kinase 1; Adenylyl-sulfate kinase; Bifunctional 3'-phosphoadenosine 5'-phosphosulfate synthase 1

3'-Phosphoadenosine 5'-Phosphosulfate Synthase 1 (PAPSS1)
CCC H451
HGNC 8603
MGI 1330587
PubMed 9576487
UniProt O43252
Wiki PAPSS1
Three-prime-phosphoadenosine 5-prime-phosphosulfate (PAPS) is the sulfate donor cosubstrate for all sulfotransferase (SULT) enzymes. SULTs catalyze the sulfate conjugation of many endogenous and exogenous compounds, including drugs and other xenobiotics. In humans, PAPS is synthesized from adenosine 5-prime triphosphate (ATP) and inorganic sulfate by 2 isoforms, PAPSS1 and PAPSS2.
The predicted 623-amino acid protein is 98% identical to mouse PAPS synthase. The N-terminal 268-amino acid region of human PAPS synthase resembles APS kinases from other organisms and contains 3 conserved nucleotide-binding motifs. The 404-amino acid C-terminal domain shares approximately 57% identity with plant ATP sulfurylase.

Organism species: Homo sapiens (Human)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins n/a Recombinant 3'-Phosphoadenosine 5'-Phosphosulfate Synthase 1 (PAPSS1) Recombinant Protein Customized Service Offer
Antibodies n/a Monoclonal Antibody to 3'-Phosphoadenosine 5'-Phosphosulfate Synthase 1 (PAPSS1) Monoclonal Antibody Customized Service Offer
n/a Polyclonal Antibody to 3'-Phosphoadenosine 5'-Phosphosulfate Synthase 1 (PAPSS1) Polyclonal Antibody Customized Service Offer
Assay Kits n/a CLIA Kit for 3'-Phosphoadenosine 5'-Phosphosulfate Synthase 1 (PAPSS1) CLIA Kit Customized Service Offer
n/a ELISA Kit for 3'-Phosphoadenosine 5'-Phosphosulfate Synthase 1 (PAPSS1) ELISA Kit Customized Service Offer

Organism species: Mus musculus (Mouse)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins n/a Recombinant 3'-Phosphoadenosine 5'-Phosphosulfate Synthase 1 (PAPSS1) Recombinant Protein Customized Service Offer
Antibodies n/a Monoclonal Antibody to 3'-Phosphoadenosine 5'-Phosphosulfate Synthase 1 (PAPSS1) Monoclonal Antibody Customized Service Offer
n/a Polyclonal Antibody to 3'-Phosphoadenosine 5'-Phosphosulfate Synthase 1 (PAPSS1) Polyclonal Antibody Customized Service Offer
Assay Kits n/a CLIA Kit for 3'-Phosphoadenosine 5'-Phosphosulfate Synthase 1 (PAPSS1) CLIA Kit Customized Service Offer
n/a ELISA Kit for 3'-Phosphoadenosine 5'-Phosphosulfate Synthase 1 (PAPSS1) ELISA Kit Customized Service Offer
  1. "Sulfation in high endothelial venules: cloning and expression of the human PAPS synthetase."FASEB J. 12:603-612(1998) [PubMed] [Europe PMC] [Abstract]
  2. "Molecular cloning, expression, and characterization of human bifunctional 3'-phosphoadenosine 5'-phosphosulfate synthase and its functional domains."J. Biol. Chem. 273:19311-19320(1998) [PubMed] [Europe PMC] [Abstract]
  3. "cDNA cloning, expression, and characterization of the human bifunctional ATP sulfurylase/adenosine 5'-phosphosulfate kinase enzyme."Biosci. Biotechnol. Biochem. 62:1037-1040(1998) [PubMed] [Europe PMC] [Abstract]
  4. "Human 3'-phosphoadenosine 5'-phosphosulfate synthetase 1 (PAPSS1) and PAPSS2: gene cloning, characterization and chromosomal localization."Biochem. Biophys. Res. Commun. 268:437-444(2000) [PubMed] [Europe PMC] [Abstract]
  5. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
  6. "Site-selected mutagenesis of a conserved nucleotide binding HXGH motif located in the ATP sulfurylase domain of human bifunctional 3'-phosphoadenosine 5'-phosphosulfate synthase."J. Biol. Chem. 274:2601-2604(1999) [PubMed] [Europe PMC] [Abstract]
  7. "Initial characterization of the human central proteome."BMC Syst. Biol. 5:17-17(2011) [PubMed] [Europe PMC] [Abstract]
  8. "Comparative large-scale characterisation of plant vs. mammal proteins reveals similar and idiosyncratic N-alpha acetylation features."Mol. Cell. Proteomics 11:M111.015131-M111.015131(2012) [PubMed] [Europe PMC] [Abstract]